HSPA12B (heat shock protein family A (Hsp70) member 12B)

2007-04-01  

Identity

HGNC
LOCATION
20p13
LOCUSID
ALIAS
C20orf60
FUSION GENES

Other Information

Locus ID:

NCBI: 116835
MIM: 610702
HGNC: 16193
Ensembl: ENSG00000132622

Variants:

dbSNP: 116835
ClinVar: 116835
TCGA: ENSG00000132622
COSMIC: HSPA12B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132622ENST00000254963Q96MM6
ENSG00000132622ENST00000399701Q5JX83

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
Regulation of HSF1-mediated heat shock responseREACTOMER-HSA-3371453

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
176013502007A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.27
189772412008Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.20
237296632013HSPA12B attenuates cardiac dysfunction and remodelling after myocardial infarction through an eNOS-dependent mechanism.20
223604202012Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.18
230468102013Overexpression of HSPA12B protects against cerebral ischemia/reperfusion injury via a PI3K/Akt-dependent mechanism.14
276443172016HSPA12B Attenuated Acute Myocardial Ischemia/reperfusion Injury via Maintaining Endothelial Integrity in a PI3K/Akt/mTOR-dependent Mechanism.12
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
270839522016Heat shock protein A12B protects against sepsis-induced impairment in vascular endothelial permeability.9
255450502015HSPA12B inhibits lipopolysaccharide-induced inflammatory response in human umbilical vein endothelial cells.6

Citation

Dessen P

HSPA12B (heat shock protein family A (Hsp70) member 12B)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46775/hspa12b