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HSPA1A (heat shock protein family A (Hsp70) member 1A)

Identity

Alias_namesHSPA1
heat shock 70kD protein 1A
heat shock 70kDa protein 1A
Alias_symbol (synonym)HSP70-1
Other aliasHEL-S-103
HSP70-1A
HSP70-2
HSP70.1
HSP70.2
HSP70I
HSP72
HGNC (Hugo) HSPA1A
LocusID (NCBI) 3303
Atlas_Id 40871
Location 6p21.33  [Link to chromosome band 6p21]
Location_base_pair Starts at 31815514 and ends at 31817942 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EFEMP1 (2p16.1) / HSPA1A (6p21.33)HSPA1A (6p21.33) / CDKN3 (14q22.2)HSPA1A (6p21.33) / FOXP1 (3p13)
PPP1R15A (19q13.33) / HSPA1A (6p21.33)SIRPB2 (20p13) / HSPA1A (6p21.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HSPA1A   5232
Cards
Entrez_Gene (NCBI)HSPA1A  3303  heat shock protein family A (Hsp70) member 1A
AliasesHEL-S-103; HSP70-1; HSP70-1A; HSP70-2; 
HSP70.1; HSP70.2; HSP70I; HSP72; HSPA1
GeneCards (Weizmann)HSPA1A
Ensembl hg19 (Hinxton)ENSG00000204389 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204389 [Gene_View]  ENSG00000204389 [Sequence]  chr6:31815514-31817942 [Contig_View]  HSPA1A [Vega]
ICGC DataPortalENSG00000204389
TCGA cBioPortalHSPA1A
AceView (NCBI)HSPA1A
Genatlas (Paris)HSPA1A
WikiGenes3303
SOURCE (Princeton)HSPA1A
Genetics Home Reference (NIH)HSPA1A
Genomic and cartography
GoldenPath hg38 (UCSC)HSPA1A  -     chr6:31815514-31817942 +  6p21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HSPA1A  -     6p21.33   [Description]    (hg19-Feb_2009)
EnsemblHSPA1A - 6p21.33 [CytoView hg19]  HSPA1A - 6p21.33 [CytoView hg38]
Mapping of homologs : NCBIHSPA1A [Mapview hg19]  HSPA1A [Mapview hg38]
OMIM140550   
Gene and transcription
Genbank (Entrez)AB209818 AK096017 AK225692 AK225699 AK291295
RefSeq transcript (Entrez)NM_005345
RefSeq genomic (Entrez)NC_000006 NG_011855 NT_113891 NT_167244 NT_167245 NT_167248
Consensus coding sequences : CCDS (NCBI)HSPA1A
Cluster EST : UnigeneHs.743411 [ NCBI ]
CGAP (NCI)Hs.743411
Alternative Splicing GalleryENSG00000204389
Gene ExpressionHSPA1A [ NCBI-GEO ]   HSPA1A [ EBI - ARRAY_EXPRESS ]   HSPA1A [ SEEK ]   HSPA1A [ MEM ]
Gene Expression Viewer (FireBrowse)HSPA1A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3303
GTEX Portal (Tissue expression)HSPA1A
Human Protein AtlasENSG00000204389-HSPA1A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP0DMV8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP0DMV8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP0DMV8
Splice isoforms : SwissVarP0DMV8
PhosPhoSitePlusP0DMV8
Domaine pattern : Prosite (Expaxy)HSP70_1 (PS00297)    HSP70_2 (PS00329)    HSP70_3 (PS01036)   
Domains : Interpro (EBI)Heat_shock_70_CS    HSP70_C_sf    HSP70_peptide-bd_sf    Hsp_70_fam   
Domain families : Pfam (Sanger)HSP70 (PF00012)   
Domain families : Pfam (NCBI)pfam00012   
Conserved Domain (NCBI)HSPA1A
DMDM Disease mutations3303
Blocks (Seattle)HSPA1A
PDB (SRS)1HJO    1S3X    1XQS    2E88    2E8A    2LMG    3A8Y    3ATU    3ATV    3AY9    3D2E    3D2F    3JXU    3LOF    3Q49    4IO8    4J8F    4PO2    4WV5    4WV7    5AQW    5AQX    5AQY    5AQZ    5AR0    5BN8    5BN9    5BPL    5BPM    5BPN    5GJJ    5MKR    5MKS   
PDB (PDBSum)1HJO    1S3X    1XQS    2E88    2E8A    2LMG    3A8Y    3ATU    3ATV    3AY9    3D2E    3D2F    3JXU    3LOF    3Q49    4IO8    4J8F    4PO2    4WV5    4WV7    5AQW    5AQX    5AQY    5AQZ    5AR0    5BN8    5BN9    5BPL    5BPM    5BPN    5GJJ    5MKR    5MKS   
PDB (IMB)1HJO    1S3X    1XQS    2E88    2E8A    2LMG    3A8Y    3ATU    3ATV    3AY9    3D2E    3D2F    3JXU    3LOF    3Q49    4IO8    4J8F    4PO2    4WV5    4WV7    5AQW    5AQX    5AQY    5AQZ    5AR0    5BN8    5BN9    5BPL    5BPM    5BPN    5GJJ    5MKR    5MKS   
PDB (RSDB)1HJO    1S3X    1XQS    2E88    2E8A    2LMG    3A8Y    3ATU    3ATV    3AY9    3D2E    3D2F    3JXU    3LOF    3Q49    4IO8    4J8F    4PO2    4WV5    4WV7    5AQW    5AQX    5AQY    5AQZ    5AR0    5BN8    5BN9    5BPL    5BPM    5BPN    5GJJ    5MKR    5MKS   
Structural Biology KnowledgeBase1HJO    1S3X    1XQS    2E88    2E8A    2LMG    3A8Y    3ATU    3ATV    3AY9    3D2E    3D2F    3JXU    3LOF    3Q49    4IO8    4J8F    4PO2    4WV5    4WV7    5AQW    5AQX    5AQY    5AQZ    5AR0    5BN8    5BN9    5BPL    5BPM    5BPN    5GJJ    5MKR    5MKS   
SCOP (Structural Classification of Proteins)1HJO    1S3X    1XQS    2E88    2E8A    2LMG    3A8Y    3ATU    3ATV    3AY9    3D2E    3D2F    3JXU    3LOF    3Q49    4IO8    4J8F    4PO2    4WV5    4WV7    5AQW    5AQX    5AQY    5AQZ    5AR0    5BN8    5BN9    5BPL    5BPM    5BPN    5GJJ    5MKR    5MKS   
CATH (Classification of proteins structures)1HJO    1S3X    1XQS    2E88    2E8A    2LMG    3A8Y    3ATU    3ATV    3AY9    3D2E    3D2F    3JXU    3LOF    3Q49    4IO8    4J8F    4PO2    4WV5    4WV7    5AQW    5AQX    5AQY    5AQZ    5AR0    5BN8    5BN9    5BPL    5BPM    5BPN    5GJJ    5MKR    5MKS   
SuperfamilyP0DMV8
Human Protein Atlas [tissue]ENSG00000204389-HSPA1A [tissue]
Peptide AtlasP0DMV8
HPRD00774
IPIIPI00304925   IPI01020720   IPI00976027   IPI00911039   IPI00939526   IPI01019017   IPI01011434   IPI01013544   IPI00845339   
Protein Interaction databases
DIP (DOE-UCLA)P0DMV8
IntAct (EBI)P0DMV8
FunCoupENSG00000204389
BioGRIDHSPA1A
STRING (EMBL)HSPA1A
ZODIACHSPA1A
Ontologies - Pathways
QuickGOP0DMV8
Ontology : AmiGOubiquitin ligase complex  virus receptor activity  G protein-coupled receptor binding  transcription corepressor activity  RNA binding  signaling receptor binding  protein binding  ATP binding  ATP binding  extracellular region  nucleus  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytoplasm  mitochondrion  endoplasmic reticulum  centrosome  centriole  cytosol  cytosol  cytosol  focal adhesion  mRNA catabolic process  response to unfolded protein  response to unfolded protein  COP9 signalosome  COP9 signalosome  negative regulation of cell proliferation  positive regulation of gene expression  regulation of cell death  inclusion body  aggresome  nuclear speck  ATPase activity  ATPase activity  enzyme binding  negative regulation of cell growth  negative regulation of transforming growth factor beta receptor signaling pathway  heat shock protein binding  heat shock protein binding  denatured protein binding  regulation of protein ubiquitination  negative regulation of protein ubiquitination  ubiquitin protein ligase binding  ubiquitin protein ligase binding  vesicle  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  positive regulation of interleukin-8 production  protein-containing complex  protein-containing complex  positive regulation of RNA splicing  cellular response to oxidative stress  cellular response to heat  cellular response to heat  cellular response to unfolded protein  cellular response to unfolded protein  protein refolding  protein refolding  protein refolding  ATPase activity, coupled  ATPase activity, coupled  ATPase activity, coupled  histone deacetylase binding  negative regulation of apoptotic process  negative regulation of apoptotic process  neutrophil degranulation  regulation of mRNA stability  protein binding involved in protein folding  protein binding involved in protein folding  cadherin binding  positive regulation of erythrocyte differentiation  ATP metabolic process  viral entry into host cell  protein N-terminus binding  perinuclear region of cytoplasm  protein stabilization  protein stabilization  protein stabilization  unfolded protein binding  unfolded protein binding  unfolded protein binding  unfolded protein binding  chaperone cofactor-dependent protein refolding  positive regulation of NF-kappaB transcription factor activity  chaperone-mediated protein complex assembly  misfolded protein binding  C3HC4-type RING finger domain binding  negative regulation of cell death  extracellular exosome  cellular heat acclimation  positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  blood microparticle  positive regulation of microtubule nucleation  negative regulation of inclusion body assembly  negative regulation of transcription from RNA polymerase II promoter in response to stress  disordered domain specific binding  regulation of cellular response to heat  negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  regulation of mitotic spindle assembly  regulation of mitotic spindle assembly  negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  positive regulation of endoribonuclease activity  positive regulation of tumor necrosis factor-mediated signaling pathway  ficolin-1-rich granule lumen  ribonucleoprotein complex  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIubiquitin ligase complex  virus receptor activity  G protein-coupled receptor binding  transcription corepressor activity  RNA binding  signaling receptor binding  protein binding  ATP binding  ATP binding  extracellular region  nucleus  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytoplasm  mitochondrion  endoplasmic reticulum  centrosome  centriole  cytosol  cytosol  cytosol  focal adhesion  mRNA catabolic process  response to unfolded protein  response to unfolded protein  COP9 signalosome  COP9 signalosome  negative regulation of cell proliferation  positive regulation of gene expression  regulation of cell death  inclusion body  aggresome  nuclear speck  ATPase activity  ATPase activity  enzyme binding  negative regulation of cell growth  negative regulation of transforming growth factor beta receptor signaling pathway  heat shock protein binding  heat shock protein binding  denatured protein binding  regulation of protein ubiquitination  negative regulation of protein ubiquitination  ubiquitin protein ligase binding  ubiquitin protein ligase binding  vesicle  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  positive regulation of interleukin-8 production  protein-containing complex  protein-containing complex  positive regulation of RNA splicing  cellular response to oxidative stress  cellular response to heat  cellular response to heat  cellular response to unfolded protein  cellular response to unfolded protein  protein refolding  protein refolding  protein refolding  ATPase activity, coupled  ATPase activity, coupled  ATPase activity, coupled  histone deacetylase binding  negative regulation of apoptotic process  negative regulation of apoptotic process  neutrophil degranulation  regulation of mRNA stability  protein binding involved in protein folding  protein binding involved in protein folding  cadherin binding  positive regulation of erythrocyte differentiation  ATP metabolic process  viral entry into host cell  protein N-terminus binding  perinuclear region of cytoplasm  protein stabilization  protein stabilization  protein stabilization  unfolded protein binding  unfolded protein binding  unfolded protein binding  unfolded protein binding  chaperone cofactor-dependent protein refolding  positive regulation of NF-kappaB transcription factor activity  chaperone-mediated protein complex assembly  misfolded protein binding  C3HC4-type RING finger domain binding  negative regulation of cell death  extracellular exosome  cellular heat acclimation  positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  blood microparticle  positive regulation of microtubule nucleation  negative regulation of inclusion body assembly  negative regulation of transcription from RNA polymerase II promoter in response to stress  disordered domain specific binding  regulation of cellular response to heat  negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  regulation of mitotic spindle assembly  regulation of mitotic spindle assembly  negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  positive regulation of endoribonuclease activity  positive regulation of tumor necrosis factor-mediated signaling pathway  ficolin-1-rich granule lumen  ribonucleoprotein complex  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : KEGGSpliceosome    MAPK signaling pathway    Protein processing in endoplasmic reticulum    Endocytosis    Antigen processing and presentation    Estrogen signaling pathway    Prion diseases    Legionellosis    Toxoplasmosis    Measles    Influenza A    Epstein-Barr virus infection   
NDEx NetworkHSPA1A
Atlas of Cancer Signalling NetworkHSPA1A
Wikipedia pathwaysHSPA1A
Orthology - Evolution
OrthoDB3303
GeneTree (enSembl)ENSG00000204389
Phylogenetic Trees/Animal Genes : TreeFamHSPA1A
HOVERGENP0DMV8
HOGENOMP0DMV8
Homologs : HomoloGeneHSPA1A
Homology/Alignments : Family Browser (UCSC)HSPA1A
Gene fusions - Rearrangements
Fusion : QuiverHSPA1A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHSPA1A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HSPA1A
dbVarHSPA1A
ClinVarHSPA1A
1000_GenomesHSPA1A 
Exome Variant ServerHSPA1A
ExAC (Exome Aggregation Consortium)ENSG00000204389
GNOMAD BrowserENSG00000204389
Varsome BrowserHSPA1A
Genetic variants : HAPMAP3303
Genomic Variants (DGV)HSPA1A [DGVbeta]
DECIPHERHSPA1A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHSPA1A 
Mutations
ICGC Data PortalHSPA1A 
TCGA Data PortalHSPA1A 
Broad Tumor PortalHSPA1A
OASIS PortalHSPA1A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHSPA1A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHSPA1A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HSPA1A
DgiDB (Drug Gene Interaction Database)HSPA1A
DoCM (Curated mutations)HSPA1A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HSPA1A (select a term)
intoGenHSPA1A
Cancer3DHSPA1A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM140550   
Orphanet
DisGeNETHSPA1A
MedgenHSPA1A
Genetic Testing Registry HSPA1A
NextProtP0DMV8 [Medical]
TSGene3303
GENETestsHSPA1A
Target ValidationHSPA1A
Huge Navigator HSPA1A [HugePedia]
snp3D : Map Gene to Disease3303
BioCentury BCIQHSPA1A
ClinGenHSPA1A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3303
Chemical/Pharm GKB GenePA29498
Clinical trialHSPA1A
Miscellaneous
canSAR (ICR)HSPA1A (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHSPA1A
EVEXHSPA1A
GoPubMedHSPA1A
iHOPHSPA1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:12:14 CET 2018

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