HSPA1A (heat shock protein family A (Hsp70) member 1A)

2003-08-01 Affiliation

Identity

HGNC

HSPA1A

LOCATION

6p21.33

LOCUSID

3303

ALIAS

HEL-S-103,HSP70-1,HSP70-1A,HSP70-2,HSP70.1,HSP70.2,HSP70I,HSP72,HSPA1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3303
MIM: 140550
HGNC: 5232
Ensembl: ENSG00000204389

Variants:

dbSNP: 3303
ClinVar: 3303
TCGA: ENSG00000204389
COSMIC: HSPA1A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000204389	ENST00000375651	P0DMV8
ENSG00000204389	ENST00000375651	A8K5I0
ENSG00000204389	ENST00000608703	V9GZ37

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Antigen processing and presentation	KEGG	ko04612
MAPK signaling pathway	KEGG	hsa04010
Antigen processing and presentation	KEGG	hsa04612
Prion diseases	KEGG	ko05020
Prion diseases	KEGG	hsa05020
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Spliceosome	KEGG	ko03040
Spliceosome	KEGG	hsa03040
Protein processing in endoplasmic reticulum	KEGG	ko04141
Protein processing in endoplasmic reticulum	KEGG	hsa04141
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Spliceosome, Prp19/CDC5L complex	KEGG	hsa_M00353
Spliceosome, 35S U5-snRNP	KEGG	hsa_M00355
Legionellosis	KEGG	ko05134
Legionellosis	KEGG	hsa05134
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
Estrogen signaling pathway	KEGG	hsa04915
Estrogen signaling pathway	KEGG	ko04915
Spliceosome, Prp19/CDC5L complex	KEGG	M00353
Spliceosome, 35S U5-snRNP	KEGG	M00355
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
Influenza Infection	REACTOME	R-HSA-168254
Influenza Life Cycle	REACTOME	R-HSA-168255
Export of Viral Ribonucleoproteins from Nucleus	REACTOME	R-HSA-168274
Viral RNP Complexes in the Host Cell Nucleus	REACTOME	R-HSA-168330
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Gene Expression	REACTOME	R-HSA-74160
Regulation of mRNA stability by proteins that bind AU-rich elements	REACTOME	R-HSA-450531
AUF1 (hnRNP D0) binds and destabilizes mRNA	REACTOME	R-HSA-450408
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular response to heat stress	REACTOME	R-HSA-3371556
HSF1-dependent transactivation	REACTOME	R-HSA-3371571
Attenuation phase	REACTOME	R-HSA-3371568
Regulation of HSF1-mediated heat shock response	REACTOME	R-HSA-3371453
Longevity regulating pathway - multiple species	KEGG	ko04213
Longevity regulating pathway - multiple species	KEGG	hsa04213
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA448785	carbamazepine	Chemical	ClinicalAnnotation	associated		PD	16538175

References

Pubmed ID	Year	Title	Citations
18772114	2008	Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis.	136
16538176	2006	Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.	112
24949977	2014	Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles.	112
16172114	2005	Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation.	106
12682040	2003	Expression of the molecular chaperone Hsp70 in detergent-resistant microdomains correlates with its membrane delivery and release.	97
12941774	2003	Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism.	93
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
15662014	2005	Mechanism of hsp70i gene bookmarking.	74
17158748	2006	The histone variant mH2A1.1 interferes with transcription by down-regulating PARP-1 enzymatic activity.	73
23349634	2013	A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.	71

Citation

Dessen P

HSPA1A (heat shock protein family A (Hsp70) member 1A)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40871/hspa1a