Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HSPA1B (heat shock protein family A (Hsp70) member 1B)

Identity

Alias_namesheat shock 70kD protein 1B
heat shock 70kDa protein 1B
Alias_symbol (synonym)HSP70-2
Other aliasHSP70-1
HSP70-1B
HSP70.1
HSP70.2
HSP72
HSPA1
HSX70
HGNC (Hugo) HSPA1B
LocusID (NCBI) 3304
Atlas_Id 40872
Location 6p21.33  [Link to chromosome band 6p21]
Location_base_pair Starts at 31827735 and ends at 31830254 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HSPA1B (6p21.33) / HSPA1B (6p21.33)HSPA1B (6p21.33) / MYLK (3q21.1)HSPA1B (6p21.33) / SLC1A3 (5p13.2)
HSPA1B 6p21.33 / MYLK 3q21.1HSPA1B 6p21.33 / SLC1A3 5p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(3;6)(q21;p21) HSPA1B/MYLK
t(5;6)(p13;p21) HSPA1B/SLC1A3


External links

Nomenclature
HGNC (Hugo)HSPA1B   5233
Cards
Entrez_Gene (NCBI)HSPA1B  3304  heat shock protein family A (Hsp70) member 1B
AliasesHSP70-1; HSP70-1B; HSP70-2; HSP70.1; 
HSP70.2; HSP72; HSPA1; HSX70
GeneCards (Weizmann)HSPA1B
Ensembl hg19 (Hinxton)ENSG00000204388 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204388 [Gene_View]  ENSG00000204388 [Sequence]  chr6:31827735-31830254 [Contig_View]  HSPA1B [Vega]
ICGC DataPortalENSG00000204388
TCGA cBioPortalHSPA1B
AceView (NCBI)HSPA1B
Genatlas (Paris)HSPA1B
WikiGenes3304
SOURCE (Princeton)HSPA1B
Genetics Home Reference (NIH)HSPA1B
Genomic and cartography
GoldenPath hg38 (UCSC)HSPA1B  -     chr6:31827735-31830254 +  6p21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HSPA1B  -     6p21.33   [Description]    (hg19-Feb_2009)
EnsemblHSPA1B - 6p21.33 [CytoView hg19]  HSPA1B - 6p21.33 [CytoView hg38]
Mapping of homologs : NCBIHSPA1B [Mapview hg19]  HSPA1B [Mapview hg38]
OMIM603012   
Gene and transcription
Genbank (Entrez)AK295398 AK303967 AL360193 BC001876 BC009322
RefSeq transcript (Entrez)NM_005346
RefSeq genomic (Entrez)NC_000006 NT_113891 NT_167244 NT_167245 NT_167248
Consensus coding sequences : CCDS (NCBI)HSPA1B
Cluster EST : UnigeneHs.719966 [ NCBI ]
CGAP (NCI)Hs.719966
Alternative Splicing GalleryENSG00000204388
Gene ExpressionHSPA1B [ NCBI-GEO ]   HSPA1B [ EBI - ARRAY_EXPRESS ]   HSPA1B [ SEEK ]   HSPA1B [ MEM ]
Gene Expression Viewer (FireBrowse)HSPA1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3304
GTEX Portal (Tissue expression)HSPA1B
Human Protein AtlasENSG00000204388-HSPA1B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP0DMV9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP0DMV9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP0DMV9
Splice isoforms : SwissVarP0DMV9
PhosPhoSitePlusP0DMV9
Domaine pattern : Prosite (Expaxy)HSP70_1 (PS00297)    HSP70_2 (PS00329)    HSP70_3 (PS01036)   
Domains : Interpro (EBI)Heat_shock_70_CS    HSP70_C_sf    HSP70_peptide-bd_sf    Hsp_70_fam   
Domain families : Pfam (Sanger)HSP70 (PF00012)   
Domain families : Pfam (NCBI)pfam00012   
Conserved Domain (NCBI)HSPA1B
DMDM Disease mutations3304
Blocks (Seattle)HSPA1B
PDB (SRS)4J8F   
PDB (PDBSum)4J8F   
PDB (IMB)4J8F   
PDB (RSDB)4J8F   
Structural Biology KnowledgeBase4J8F   
SCOP (Structural Classification of Proteins)4J8F   
CATH (Classification of proteins structures)4J8F   
SuperfamilyP0DMV9
Human Protein Atlas [tissue]ENSG00000204388-HSPA1B [tissue]
Peptide AtlasP0DMV9
HPRD06784
Protein Interaction databases
DIP (DOE-UCLA)P0DMV9
IntAct (EBI)P0DMV9
FunCoupENSG00000204388
BioGRIDHSPA1B
STRING (EMBL)HSPA1B
ZODIACHSPA1B
Ontologies - Pathways
QuickGOP0DMV9
Ontology : AmiGOubiquitin ligase complex  virus receptor activity  G protein-coupled receptor binding  RNA binding  signaling receptor binding  protein binding  ATP binding  ATP binding  extracellular region  nucleus  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytoplasm  mitochondrion  endoplasmic reticulum  centrosome  centriole  cytosol  cytosol  cytosol  focal adhesion  mRNA catabolic process  response to unfolded protein  COP9 signalosome  negative regulation of cell proliferation  positive regulation of gene expression  regulation of cell death  inclusion body  aggresome  nuclear speck  ATPase activity  ATPase activity  enzyme binding  negative regulation of cell growth  heat shock protein binding  heat shock protein binding  regulation of protein ubiquitination  negative regulation of protein ubiquitination  ubiquitin protein ligase binding  ubiquitin protein ligase binding  vesicle  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  positive regulation of interleukin-8 production  protein-containing complex  protein-containing complex  cellular response to oxidative stress  cellular response to heat  cellular response to heat  cellular response to unfolded protein  protein refolding  protein refolding  protein refolding  ATPase activity, coupled  ATPase activity, coupled  ATPase activity, coupled  histone deacetylase binding  negative regulation of apoptotic process  negative regulation of apoptotic process  neutrophil degranulation  protein binding involved in protein folding  protein binding involved in protein folding  positive regulation of erythrocyte differentiation  ATP metabolic process  viral entry into host cell  protein N-terminus binding  perinuclear region of cytoplasm  protein stabilization  protein stabilization  unfolded protein binding  unfolded protein binding  unfolded protein binding  unfolded protein binding  chaperone cofactor-dependent protein refolding  positive regulation of NF-kappaB transcription factor activity  misfolded protein binding  C3HC4-type RING finger domain binding  negative regulation of cell death  negative regulation of cell death  extracellular exosome  cellular heat acclimation  positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  blood microparticle  positive regulation of microtubule nucleation  negative regulation of inclusion body assembly  regulation of cellular response to heat  regulation of mitotic spindle assembly  regulation of mitotic spindle assembly  positive regulation of tumor necrosis factor-mediated signaling pathway  ficolin-1-rich granule lumen  ribonucleoprotein complex  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIubiquitin ligase complex  virus receptor activity  G protein-coupled receptor binding  RNA binding  signaling receptor binding  protein binding  ATP binding  ATP binding  extracellular region  nucleus  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytoplasm  mitochondrion  endoplasmic reticulum  centrosome  centriole  cytosol  cytosol  cytosol  focal adhesion  mRNA catabolic process  response to unfolded protein  COP9 signalosome  negative regulation of cell proliferation  positive regulation of gene expression  regulation of cell death  inclusion body  aggresome  nuclear speck  ATPase activity  ATPase activity  enzyme binding  negative regulation of cell growth  heat shock protein binding  heat shock protein binding  regulation of protein ubiquitination  negative regulation of protein ubiquitination  ubiquitin protein ligase binding  ubiquitin protein ligase binding  vesicle  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  positive regulation of interleukin-8 production  protein-containing complex  protein-containing complex  cellular response to oxidative stress  cellular response to heat  cellular response to heat  cellular response to unfolded protein  protein refolding  protein refolding  protein refolding  ATPase activity, coupled  ATPase activity, coupled  ATPase activity, coupled  histone deacetylase binding  negative regulation of apoptotic process  negative regulation of apoptotic process  neutrophil degranulation  protein binding involved in protein folding  protein binding involved in protein folding  positive regulation of erythrocyte differentiation  ATP metabolic process  viral entry into host cell  protein N-terminus binding  perinuclear region of cytoplasm  protein stabilization  protein stabilization  unfolded protein binding  unfolded protein binding  unfolded protein binding  unfolded protein binding  chaperone cofactor-dependent protein refolding  positive regulation of NF-kappaB transcription factor activity  misfolded protein binding  C3HC4-type RING finger domain binding  negative regulation of cell death  negative regulation of cell death  extracellular exosome  cellular heat acclimation  positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  blood microparticle  positive regulation of microtubule nucleation  negative regulation of inclusion body assembly  regulation of cellular response to heat  regulation of mitotic spindle assembly  regulation of mitotic spindle assembly  positive regulation of tumor necrosis factor-mediated signaling pathway  ficolin-1-rich granule lumen  ribonucleoprotein complex  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : KEGGSpliceosome    MAPK signaling pathway    Protein processing in endoplasmic reticulum    Endocytosis    Antigen processing and presentation    Estrogen signaling pathway    Legionellosis    Toxoplasmosis    Measles    Influenza A    Epstein-Barr virus infection   
NDEx NetworkHSPA1B
Atlas of Cancer Signalling NetworkHSPA1B
Wikipedia pathwaysHSPA1B
Orthology - Evolution
OrthoDB3304
GeneTree (enSembl)ENSG00000204388
Phylogenetic Trees/Animal Genes : TreeFamHSPA1B
HOVERGENP0DMV9
HOGENOMP0DMV9
Homologs : HomoloGeneHSPA1B
Homology/Alignments : Family Browser (UCSC)HSPA1B
Gene fusions - Rearrangements
Fusion : MitelmanHSPA1B/MYLK [6p21.33/3q21.1]  
Fusion : MitelmanHSPA1B/SLC1A3 [6p21.33/5p13.2]  [t(5;6)(p13;p21)]  
Fusion PortalHSPA1B 6p21.33 MYLK 3q21.1 PRAD
Fusion PortalHSPA1B 6p21.33 SLC1A3 5p13.2 LGG
Fusion : QuiverHSPA1B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHSPA1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HSPA1B
dbVarHSPA1B
ClinVarHSPA1B
1000_GenomesHSPA1B 
Exome Variant ServerHSPA1B
ExAC (Exome Aggregation Consortium)ENSG00000204388
GNOMAD BrowserENSG00000204388
Varsome BrowserHSPA1B
Genetic variants : HAPMAP3304
Genomic Variants (DGV)HSPA1B [DGVbeta]
DECIPHERHSPA1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHSPA1B 
Mutations
ICGC Data PortalHSPA1B 
TCGA Data PortalHSPA1B 
Broad Tumor PortalHSPA1B
OASIS PortalHSPA1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHSPA1B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHSPA1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HSPA1B
DgiDB (Drug Gene Interaction Database)HSPA1B
DoCM (Curated mutations)HSPA1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HSPA1B (select a term)
intoGenHSPA1B
Cancer3DHSPA1B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603012   
Orphanet
DisGeNETHSPA1B
MedgenHSPA1B
Genetic Testing Registry HSPA1B
NextProtP0DMV9 [Medical]
TSGene3304
GENETestsHSPA1B
Target ValidationHSPA1B
Huge Navigator HSPA1B [HugePedia]
snp3D : Map Gene to Disease3304
BioCentury BCIQHSPA1B
ClinGenHSPA1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3304
Chemical/Pharm GKB GenePA29499
Clinical trialHSPA1B
Miscellaneous
canSAR (ICR)HSPA1B (select the gene name)
Probes
Litterature
PubMed237 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHSPA1B
EVEXHSPA1B
GoPubMedHSPA1B
iHOPHSPA1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:12:14 CET 2018

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