HSPA1B (heat shock protein family A (Hsp70) member 1B)

2003-06-01  

Identity

HGNC
LOCATION
6p21.33
LOCUSID
ALIAS
HSP70-1,HSP70-1B,HSP70-2,HSP70.1,HSP70.2,HSP72,HSPA1,HSX70
FUSION GENES

Other Information

Locus ID:

NCBI: 3304
MIM: 603012
HGNC: 5233
Ensembl: ENSG00000204388

Variants:

dbSNP: 3304
ClinVar: 3304
TCGA: ENSG00000204388
COSMIC: HSPA1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204388ENST00000375650P0DMV9
ENSG00000204388ENST00000375650A8K5I0

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Antigen processing and presentationKEGGko04612
MAPK signaling pathwayKEGGhsa04010
Antigen processing and presentationKEGGhsa04612
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Spliceosome, Prp19/CDC5L complexKEGGhsa_M00353
Spliceosome, 35S U5-snRNPKEGGhsa_M00355
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Estrogen signaling pathwayKEGGhsa04915
Estrogen signaling pathwayKEGGko04915
Spliceosome, Prp19/CDC5L complexKEGGM00353
Spliceosome, 35S U5-snRNPKEGGM00355
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
HSF1-dependent transactivationREACTOMER-HSA-3371571
Attenuation phaseREACTOMER-HSA-3371568
Regulation of HSF1-mediated heat shock responseREACTOMER-HSA-3371453
Longevity regulating pathway - multiple speciesKEGGko04213
Longevity regulating pathway - multiple speciesKEGGhsa04213
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
171587482006The histone variant mH2A1.1 interferes with transcription by down-regulating PARP-1 enzymatic activity.73
233496342013A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.71
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.51
124115382002Exercise induces hepatosplanchnic release of heat shock protein 72 in humans.47
123911422002Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1.46
119719732002Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosis.37
146058732004Analysis of heat-shock protein 70 gene polymorphisms and the risk of Parkinson's disease.31
188187482008Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.31
195275142009Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.31
190193352009Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.26

Citation

Dessen P

HSPA1B (heat shock protein family A (Hsp70) member 1B)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40872/hspa1b