Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HSPA1L (heat shock protein family A (Hsp70) member 1 like)

Identity

Alias_namesheat shock 70kD protein-like 1
heat shock 70kDa protein 1-like
Alias_symbol (synonym)HSP70-HOM
hum70t
Other aliasHSP70-1L
HSP70T
HGNC (Hugo) HSPA1L
LocusID (NCBI) 3305
Atlas_Id 40873
Location 6p21.33  [Link to chromosome band 6p21]
Location_base_pair Starts at 31809619 and ends at 31815058 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TNS3 (7p12.3) / HSPA1L (6p21.33)TNS3 7p12.3 / HSPA1L 6p21.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;7)(p21;p12) TNS3/HSPA1L


External links

Nomenclature
HGNC (Hugo)HSPA1L   5234
Cards
Entrez_Gene (NCBI)HSPA1L  3305  heat shock protein family A (Hsp70) member 1 like
AliasesHSP70-1L; HSP70-HOM; HSP70T; hum70t
GeneCards (Weizmann)HSPA1L
Ensembl hg19 (Hinxton)ENSG00000204390 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204390 [Gene_View]  ENSG00000204390 [Sequence]  chr6:31809619-31815058 [Contig_View]  HSPA1L [Vega]
ICGC DataPortalENSG00000204390
TCGA cBioPortalHSPA1L
AceView (NCBI)HSPA1L
Genatlas (Paris)HSPA1L
WikiGenes3305
SOURCE (Princeton)HSPA1L
Genetics Home Reference (NIH)HSPA1L
Genomic and cartography
GoldenPath hg38 (UCSC)HSPA1L  -     chr6:31809619-31815058 -  6p21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HSPA1L  -     6p21.33   [Description]    (hg19-Feb_2009)
EnsemblHSPA1L - 6p21.33 [CytoView hg19]  HSPA1L - 6p21.33 [CytoView hg38]
Mapping of homologs : NCBIHSPA1L [Mapview hg19]  HSPA1L [Mapview hg38]
OMIM140559   
Gene and transcription
Genbank (Entrez)AK223386 AK295416 AK302179 AK315227 BC034483
RefSeq transcript (Entrez)NM_005527
RefSeq genomic (Entrez)NC_000006 NG_011855 NT_113891 NT_167244 NT_167245 NT_167248
Consensus coding sequences : CCDS (NCBI)HSPA1L
Cluster EST : UnigeneHs.690634 [ NCBI ]
CGAP (NCI)Hs.690634
Alternative Splicing GalleryENSG00000204390
Gene ExpressionHSPA1L [ NCBI-GEO ]   HSPA1L [ EBI - ARRAY_EXPRESS ]   HSPA1L [ SEEK ]   HSPA1L [ MEM ]
Gene Expression Viewer (FireBrowse)HSPA1L [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3305
GTEX Portal (Tissue expression)HSPA1L
Human Protein AtlasENSG00000204390-HSPA1L [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP34931   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP34931  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP34931
Splice isoforms : SwissVarP34931
PhosPhoSitePlusP34931
Domaine pattern : Prosite (Expaxy)HSP70_1 (PS00297)    HSP70_2 (PS00329)    HSP70_3 (PS01036)   
Domains : Interpro (EBI)Heat_shock_70_CS    HSP70_C_sf    HSP70_peptide-bd_sf    Hsp_70_fam   
Domain families : Pfam (Sanger)HSP70 (PF00012)   
Domain families : Pfam (NCBI)pfam00012   
Conserved Domain (NCBI)HSPA1L
DMDM Disease mutations3305
Blocks (Seattle)HSPA1L
PDB (SRS)3GDQ   
PDB (PDBSum)3GDQ   
PDB (IMB)3GDQ   
PDB (RSDB)3GDQ   
Structural Biology KnowledgeBase3GDQ   
SCOP (Structural Classification of Proteins)3GDQ   
CATH (Classification of proteins structures)3GDQ   
SuperfamilyP34931
Human Protein Atlas [tissue]ENSG00000204390-HSPA1L [tissue]
Peptide AtlasP34931
HPRD00776
IPIIPI00939442   IPI00643152   IPI01021676   IPI01022141   IPI00830052   IPI00940553   IPI00893099   
Protein Interaction databases
DIP (DOE-UCLA)P34931
IntAct (EBI)P34931
FunCoupENSG00000204390
BioGRIDHSPA1L
STRING (EMBL)HSPA1L
ZODIACHSPA1L
Ontologies - Pathways
QuickGOP34931
Ontology : AmiGOzona pellucida receptor complex  protein binding  ATP binding  nucleoplasm  cytoplasm  cytosol  cytosol  response to unfolded protein  binding of sperm to zona pellucida  COP9 signalosome  ATPase activity  heat shock protein binding  heat shock protein binding  ubiquitin protein ligase binding  cellular response to heat  cellular response to unfolded protein  protein refolding  protein refolding  ATPase activity, coupled  protein binding involved in protein folding  cell body  unfolded protein binding  unfolded protein binding  chaperone cofactor-dependent protein refolding  misfolded protein binding  blood microparticle  regulation of cellular response to heat  positive regulation of protein targeting to mitochondrion  
Ontology : EGO-EBIzona pellucida receptor complex  protein binding  ATP binding  nucleoplasm  cytoplasm  cytosol  cytosol  response to unfolded protein  binding of sperm to zona pellucida  COP9 signalosome  ATPase activity  heat shock protein binding  heat shock protein binding  ubiquitin protein ligase binding  cellular response to heat  cellular response to unfolded protein  protein refolding  protein refolding  ATPase activity, coupled  protein binding involved in protein folding  cell body  unfolded protein binding  unfolded protein binding  chaperone cofactor-dependent protein refolding  misfolded protein binding  blood microparticle  regulation of cellular response to heat  positive regulation of protein targeting to mitochondrion  
Pathways : KEGGSpliceosome    MAPK signaling pathway    Protein processing in endoplasmic reticulum    Endocytosis    Antigen processing and presentation    Estrogen signaling pathway    Legionellosis    Toxoplasmosis    Measles    Influenza A    Epstein-Barr virus infection   
NDEx NetworkHSPA1L
Atlas of Cancer Signalling NetworkHSPA1L
Wikipedia pathwaysHSPA1L
Orthology - Evolution
OrthoDB3305
GeneTree (enSembl)ENSG00000204390
Phylogenetic Trees/Animal Genes : TreeFamHSPA1L
HOVERGENP34931
HOGENOMP34931
Homologs : HomoloGeneHSPA1L
Homology/Alignments : Family Browser (UCSC)HSPA1L
Gene fusions - Rearrangements
Fusion : MitelmanTNS3/HSPA1L [7p12.3/6p21.33]  [t(6;7)(p21;p12)]  
Fusion PortalTNS3 7p12.3 HSPA1L 6p21.33 BRCA
Fusion : QuiverHSPA1L
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHSPA1L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HSPA1L
dbVarHSPA1L
ClinVarHSPA1L
1000_GenomesHSPA1L 
Exome Variant ServerHSPA1L
ExAC (Exome Aggregation Consortium)ENSG00000204390
GNOMAD BrowserENSG00000204390
Varsome BrowserHSPA1L
Genetic variants : HAPMAP3305
Genomic Variants (DGV)HSPA1L [DGVbeta]
DECIPHERHSPA1L [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHSPA1L 
Mutations
ICGC Data PortalHSPA1L 
TCGA Data PortalHSPA1L 
Broad Tumor PortalHSPA1L
OASIS PortalHSPA1L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHSPA1L  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHSPA1L
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HSPA1L
DgiDB (Drug Gene Interaction Database)HSPA1L
DoCM (Curated mutations)HSPA1L (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HSPA1L (select a term)
intoGenHSPA1L
Cancer3DHSPA1L(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM140559   
Orphanet
DisGeNETHSPA1L
MedgenHSPA1L
Genetic Testing Registry HSPA1L
NextProtP34931 [Medical]
TSGene3305
GENETestsHSPA1L
Target ValidationHSPA1L
Huge Navigator HSPA1L [HugePedia]
snp3D : Map Gene to Disease3305
BioCentury BCIQHSPA1L
ClinGenHSPA1L
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3305
Chemical/Pharm GKB GenePA29500
Clinical trialHSPA1L
Miscellaneous
canSAR (ICR)HSPA1L (select the gene name)
Probes
Litterature
PubMed152 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHSPA1L
EVEXHSPA1L
GoPubMedHSPA1L
iHOPHSPA1L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:12:14 CET 2018

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