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HSPA4 (heat shock protein family A (Hsp70) member 4)

Identity

Alias_namesheat shock 70kD protein 4
heat shock 70kDa protein 4
Alias_symbol (synonym)HS24/P52
HSPH2
Other aliasAPG-2
HEL-S-5a
RY
hsp70
hsp70RY
HGNC (Hugo) HSPA4
LocusID (NCBI) 3308
Atlas_Id 40875
Location 5q31.1  [Link to chromosome band 5q31]
Location_base_pair Starts at 132387662 and ends at 132440709 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
HSPA4 (5q31.1) / HSPA4 (5q31.1)MATR3 (5q31.2) / HSPA4 (5q31.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HSPA4   5237
Cards
Entrez_Gene (NCBI)HSPA4  3308  heat shock protein family A (Hsp70) member 4
AliasesAPG-2; HEL-S-5a; HS24/P52; HSPH2; 
RY; hsp70; hsp70RY
GeneCards (Weizmann)HSPA4
Ensembl hg19 (Hinxton)ENSG00000170606 [Gene_View]  chr5:132387662-132440709 [Contig_View]  HSPA4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000170606 [Gene_View]  chr5:132387662-132440709 [Contig_View]  HSPA4 [Vega]
ICGC DataPortalENSG00000170606
TCGA cBioPortalHSPA4
AceView (NCBI)HSPA4
Genatlas (Paris)HSPA4
WikiGenes3308
SOURCE (Princeton)HSPA4
Genetics Home Reference (NIH)HSPA4
Genomic and cartography
GoldenPath hg19 (UCSC)HSPA4  -     chr5:132387662-132440709 +  5q31.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HSPA4  -     5q31.1   [Description]    (hg38-Dec_2013)
EnsemblHSPA4 - 5q31.1 [CytoView hg19]  HSPA4 - 5q31.1 [CytoView hg38]
Mapping of homologs : NCBIHSPA4 [Mapview hg19]  HSPA4 [Mapview hg38]
OMIM601113   
Gene and transcription
Genbank (Entrez)AB023420 AB209151 AK294859 AK295847 AK297762
RefSeq transcript (Entrez)NM_002154 NM_198431
RefSeq genomic (Entrez)NC_000005 NC_018916 NT_034772 NW_004929323
Consensus coding sequences : CCDS (NCBI)HSPA4
Cluster EST : UnigeneHs.90093 [ NCBI ]
CGAP (NCI)Hs.90093
Alternative Splicing GalleryENSG00000170606
Gene ExpressionHSPA4 [ NCBI-GEO ]   HSPA4 [ EBI - ARRAY_EXPRESS ]   HSPA4 [ SEEK ]   HSPA4 [ MEM ]
Gene Expression Viewer (FireBrowse)HSPA4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3308
GTEX Portal (Tissue expression)HSPA4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP34932   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP34932  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP34932
Splice isoforms : SwissVarP34932
PhosPhoSitePlusP34932
Domaine pattern : Prosite (Expaxy)HSP70_2 (PS00329)    HSP70_3 (PS01036)   
Domains : Interpro (EBI)Heat_shock_70_CS    HSP70_C    HSP70_peptide-bd    Hsp_70_fam   
Domain families : Pfam (Sanger)HSP70 (PF00012)   
Domain families : Pfam (NCBI)pfam00012   
Conserved Domain (NCBI)HSPA4
DMDM Disease mutations3308
Blocks (Seattle)HSPA4
SuperfamilyP34932
Human Protein AtlasENSG00000170606
Peptide AtlasP34932
HPRD09025
IPIIPI00002966   IPI01010895   IPI00031022   
Protein Interaction databases
DIP (DOE-UCLA)P34932
IntAct (EBI)P34932
FunCoupENSG00000170606
BioGRIDHSPA4
STRING (EMBL)HSPA4
ZODIACHSPA4
Ontologies - Pathways
QuickGOP34932
Ontology : AmiGOprotein binding  ATP binding  cytosol  response to unfolded protein  protein import into mitochondrial outer membrane  chaperone-mediated protein complex assembly  extracellular exosome  
Ontology : EGO-EBIprotein binding  ATP binding  cytosol  response to unfolded protein  protein import into mitochondrial outer membrane  chaperone-mediated protein complex assembly  extracellular exosome  
Pathways : KEGGAntigen processing and presentation   
NDEx NetworkHSPA4
Atlas of Cancer Signalling NetworkHSPA4
Wikipedia pathwaysHSPA4
Orthology - Evolution
OrthoDB3308
GeneTree (enSembl)ENSG00000170606
Phylogenetic Trees/Animal Genes : TreeFamHSPA4
HOVERGENP34932
HOGENOMP34932
Homologs : HomoloGeneHSPA4
Homology/Alignments : Family Browser (UCSC)HSPA4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHSPA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HSPA4
dbVarHSPA4
ClinVarHSPA4
1000_GenomesHSPA4 
Exome Variant ServerHSPA4
ExAC (Exome Aggregation Consortium)HSPA4 (select the gene name)
Genetic variants : HAPMAP3308
Genomic Variants (DGV)HSPA4 [DGVbeta]
DECIPHER (Syndromes)5:132387662-132440709  ENSG00000170606
CONAN: Copy Number AnalysisHSPA4 
Mutations
ICGC Data PortalHSPA4 
TCGA Data PortalHSPA4 
Broad Tumor PortalHSPA4
OASIS PortalHSPA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHSPA4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHSPA4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HSPA4
DgiDB (Drug Gene Interaction Database)HSPA4
DoCM (Curated mutations)HSPA4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HSPA4 (select a term)
intoGenHSPA4
Cancer3DHSPA4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601113   
Orphanet
MedgenHSPA4
Genetic Testing Registry HSPA4
NextProtP34932 [Medical]
TSGene3308
GENETestsHSPA4
Huge Navigator HSPA4 [HugePedia]
snp3D : Map Gene to Disease3308
BioCentury BCIQHSPA4
ClinGenHSPA4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3308
Chemical/Pharm GKB GenePA29503
Clinical trialHSPA4
Miscellaneous
canSAR (ICR)HSPA4 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHSPA4
EVEXHSPA4
GoPubMedHSPA4
iHOPHSPA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:09:55 CET 2017

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