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HSPA4 (heat shock protein family A (Hsp70) member 4)

Identity

Alias (NCBI)APG-2
HEL-S-5a
HS24/P52
HSPH2
RY
hsp70
hsp70RY
HGNC (Hugo) HSPA4
HGNC Alias symbHS24/P52
HSPH2
HGNC Alias namehsp70 RY
HGNC Previous nameheat shock 70kD protein 4
 heat shock 70kDa protein 4
LocusID (NCBI) 3308
Atlas_Id 40875
Location 5q31.1  [Link to chromosome band 5q31]
Location_base_pair Starts at 133052013 and ends at 133106449 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HSPA4 (5q31.1) / HSPA4 (5q31.1)MATR3 (5q31.2) / HSPA4 (5q31.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)HSPA4   5237
Cards
Entrez_Gene (NCBI)HSPA4    heat shock protein family A (Hsp70) member 4
AliasesAPG-2; HEL-S-5a; HS24/P52; HSPH2; 
RY; hsp70; hsp70RY
GeneCards (Weizmann)HSPA4
Ensembl hg19 (Hinxton)ENSG00000170606 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170606 [Gene_View]  ENSG00000170606 [Sequence]  chr5:133052013-133106449 [Contig_View]  HSPA4 [Vega]
ICGC DataPortalENSG00000170606
TCGA cBioPortalHSPA4
AceView (NCBI)HSPA4
Genatlas (Paris)HSPA4
SOURCE (Princeton)HSPA4
Genetics Home Reference (NIH)HSPA4
Genomic and cartography
GoldenPath hg38 (UCSC)HSPA4  -     chr5:133052013-133106449 +  5q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HSPA4  -     5q31.1   [Description]    (hg19-Feb_2009)
GoldenPathHSPA4 - 5q31.1 [CytoView hg19]  HSPA4 - 5q31.1 [CytoView hg38]
ImmunoBaseENSG00000170606
genome Data Viewer NCBIHSPA4 [Mapview hg19]  
OMIM601113   
Gene and transcription
Genbank (Entrez)AB023420 AB209151 AK294859 AK295847 AK297762
RefSeq transcript (Entrez)NM_002154 NM_198431
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HSPA4
Alternative Splicing GalleryENSG00000170606
Gene ExpressionHSPA4 [ NCBI-GEO ]   HSPA4 [ EBI - ARRAY_EXPRESS ]   HSPA4 [ SEEK ]   HSPA4 [ MEM ]
Gene Expression Viewer (FireBrowse)HSPA4 [ Firebrowse - Broad ]
GenevisibleExpression of HSPA4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3308
GTEX Portal (Tissue expression)HSPA4
Human Protein AtlasENSG00000170606-HSPA4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP34932   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP34932  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP34932
Splice isoforms : SwissVarP34932
PhosPhoSitePlusP34932
Domaine pattern : Prosite (Expaxy)HSP70_2 (PS00329)    HSP70_3 (PS01036)   
Domains : Interpro (EBI)ATPase_NBD    Heat_shock_70_CS    HSP70_C_sf    HSP70_peptide-bd_sf    Hsp_70_fam    HSPA4_NBD   
Domain families : Pfam (Sanger)HSP70 (PF00012)   
Domain families : Pfam (NCBI)pfam00012   
Conserved Domain (NCBI)HSPA4
Blocks (Seattle)HSPA4
SuperfamilyP34932
Human Protein Atlas [tissue]ENSG00000170606-HSPA4 [tissue]
Peptide AtlasP34932
HPRD09025
IPIIPI00002966   IPI01010895   IPI00031022   
Protein Interaction databases
DIP (DOE-UCLA)P34932
IntAct (EBI)P34932
BioGRIDHSPA4
STRING (EMBL)HSPA4
ZODIACHSPA4
Ontologies - Pathways
QuickGOP34932
Ontology : AmiGOprotein binding  ATP binding  nucleus  mitochondrion  cytosol  cytosol  response to unfolded protein  protein insertion into mitochondrial outer membrane  chaperone-mediated protein complex assembly  extracellular exosome  extracellular exosome  
Ontology : EGO-EBIprotein binding  ATP binding  nucleus  mitochondrion  cytosol  cytosol  response to unfolded protein  protein insertion into mitochondrial outer membrane  chaperone-mediated protein complex assembly  extracellular exosome  extracellular exosome  
Pathways : KEGGAntigen processing and presentation   
NDEx NetworkHSPA4
Atlas of Cancer Signalling NetworkHSPA4
Wikipedia pathwaysHSPA4
Orthology - Evolution
OrthoDB3308
GeneTree (enSembl)ENSG00000170606
Phylogenetic Trees/Animal Genes : TreeFamHSPA4
HOGENOMP34932
Homologs : HomoloGeneHSPA4
Homology/Alignments : Family Browser (UCSC)HSPA4
Gene fusions - Rearrangements
Fusion : QuiverHSPA4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHSPA4 [hg38]
dbVarHSPA4
ClinVarHSPA4
MonarchHSPA4
1000_GenomesHSPA4 
Exome Variant ServerHSPA4
GNOMAD BrowserENSG00000170606
Varsome BrowserHSPA4
Genomic Variants (DGV)HSPA4 [DGVbeta]
DECIPHERHSPA4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHSPA4 
Mutations
ICGC Data PortalHSPA4 
TCGA Data PortalHSPA4 
Broad Tumor PortalHSPA4
OASIS PortalHSPA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHSPA4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHSPA4
Mutations and Diseases : HGMDHSPA4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HSPA4
DgiDB (Drug Gene Interaction Database)HSPA4
DoCM (Curated mutations)HSPA4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HSPA4 (select a term)
intoGenHSPA4
Cancer3DHSPA4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601113   
Orphanet
DisGeNETHSPA4
MedgenHSPA4
Genetic Testing Registry HSPA4
NextProtP34932 [Medical]
GENETestsHSPA4
Target ValidationHSPA4
Huge Navigator HSPA4 [HugePedia]
ClinGenHSPA4
Clinical trials, drugs, therapy
MyCancerGenomeHSPA4
Protein Interactions : CTD
Pharm GKB GenePA29503
PharosP34932
Clinical trialHSPA4
Miscellaneous
canSAR (ICR)HSPA4 (select the gene name)
HarmonizomeHSPA4
DataMed IndexHSPA4
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHSPA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 25 19:25:51 CET 2021

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