HSPA4L (heat shock protein family A (Hsp70) member 4 like)

2007-04-01  

Identity

HGNC
HSPA4L
LOCATION
4q28.1
LOCUSID
22824
ALIAS
APG-1,APG1,HSPH3,Osp94
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22824
HGNC: 17041
Ensembl: ENSG00000164070

Variants:

dbSNP: 22824
ClinVar: 22824
TCGA: ENSG00000164070
COSMIC: HSPA4L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164070ENST00000296464O95757
ENSG00000164070ENST00000296464A0A140VKE7
ENSG00000164070ENST00000505726E9PDE8
ENSG00000164070ENST00000508549D6RJ96
ENSG00000164070ENST00000508776O95757
ENSG00000164070ENST00000508776A0A140VKE7

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
Regulation of HSF1-mediated heat shock responseREACTOMER-HSA-3371453

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
318992172020Role of Apg-1 in HSF1 activation and bortezomib sensitivity in myeloma cells.0
318992172020Role of Apg-1 in HSF1 activation and bortezomib sensitivity in myeloma cells.0
306378422019Decreased expression of heat shock protein A4L in spermatozoa is positively related to poor human sperm quality.11
306378422019Decreased expression of heat shock protein A4L in spermatozoa is positively related to poor human sperm quality.11
264860822015The potent tumor suppressor miR-497 inhibits cancer phenotypes in nasopharyngeal carcinoma by targeting ANLN and HSPA4L.35
264860822015The potent tumor suppressor miR-497 inhibits cancer phenotypes in nasopharyngeal carcinoma by targeting ANLN and HSPA4L.35
235092522013Molecular chaperone Hsp110 rescues a vesicle transport defect produced by an ALS-associated mutant SOD1 protein in squid axoplasm.35
240916762013Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110.45
235092522013Molecular chaperone Hsp110 rescues a vesicle transport defect produced by an ALS-associated mutant SOD1 protein in squid axoplasm.35
240916762013Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110.45
219465392011Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis.63
219465392011Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis.63
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.14
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.14
129529232003Intestinal heat shock protein 110 regulates expression of CD1d on intestinal epithelial cells.10

Citation

Dessen P

HSPA4L (heat shock protein family A (Hsp70) member 4 like)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47179/hspa4l