Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

HSPA9 (heat shock protein family A (Hsp70) member 9)

Identity

Alias (NCBI)CRP40
CSA
EVPLS
GRP-75
GRP75
HEL-S-124m
HSPA9B
MOT
MOT2
MTHSP75
PBP74
SAAN
SIDBA4
HGNC (Hugo) HSPA9
HGNC Alias symbGRP75
PBP74
mot-2
mthsp75
HGNC Alias namemortalin2
 mortalin
 75 kDa glucose-regulated protein
 Stress-70 protein, mitochondrial
HGNC Previous nameHSPA9B
HGNC Previous nameheat shock 70kDa protein 9B (mortalin-2)
 heat shock 70kDa protein 9 (mortalin)
LocusID (NCBI) 3313
Atlas_Id 40879
Location 5q31.2  [Link to chromosome band 5q31]
Location_base_pair Starts at 138553759 and ends at 138575401 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARF1 (1q42.13) / HSPA9 (5q31.2)ARFRP1 (20q13.33) / HSPA9 (5q31.2)ARHGAP26 (5q31.3) / HSPA9 (5q31.2)
HSPA9 (5q31.2) / ARL15 (5q11.2)HSPA9 (5q31.2) / HSPA9 (5q31.2)HSPA9 (5q31.2) / NEFL (8p21.2)
HSPA9 (5q31.2) / RMND5B (5q35.3)HSPA9 (5q31.2) / RPS20 (8q12.1)HSPA9 (5q31.2) / SLC35A2 (Xp11.23)
HSPA9 (5q31.2) / TMCO6 (5q31.3)INA (10q24.33) / HSPA9 (5q31.2)MARCH6 (5p15.2) / HSPA9 (5q31.2)
TBC1D25 (Xp11.23) / HSPA9 (5q31.2)ZRANB1 (10q26.13) / HSPA9 (5q31.2)ARF1 1q42.13 / HSPA9 5q31.2
HSPA9 5q31.2 / ARL15 5q11.2TBC1D25 Xp11.23 / HSPA9 5q31.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)HSPA9   5244
Cards
Entrez_Gene (NCBI)HSPA9    heat shock protein family A (Hsp70) member 9
AliasesCRP40; CSA; EVPLS; GRP-75; 
GRP75; HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN; SIDBA4
GeneCards (Weizmann)HSPA9
Ensembl hg19 (Hinxton)ENSG00000113013 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113013 [Gene_View]  ENSG00000113013 [Sequence]  chr5:138553759-138575401 [Contig_View]  HSPA9 [Vega]
ICGC DataPortalENSG00000113013
TCGA cBioPortalHSPA9
AceView (NCBI)HSPA9
Genatlas (Paris)HSPA9
SOURCE (Princeton)HSPA9
Genetics Home Reference (NIH)HSPA9
Genomic and cartography
GoldenPath hg38 (UCSC)HSPA9  -     chr5:138553759-138575401 -  5q31.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HSPA9  -     5q31.2   [Description]    (hg19-Feb_2009)
GoldenPathHSPA9 - 5q31.2 [CytoView hg19]  HSPA9 - 5q31.2 [CytoView hg38]
ImmunoBaseENSG00000113013
Genome Data Viewer NCBIHSPA9 [Mapview hg19]  
OMIM182170   600548   616854   
Gene and transcription
Genbank (Entrez)AK023317 AK222758 AK225488 AK293990 AK297795
RefSeq transcript (Entrez)NM_004134
Consensus coding sequences : CCDS (NCBI)HSPA9
Gene ExpressionHSPA9 [ NCBI-GEO ]   HSPA9 [ EBI - ARRAY_EXPRESS ]   HSPA9 [ SEEK ]   HSPA9 [ MEM ]
Gene Expression Viewer (FireBrowse)HSPA9 [ Firebrowse - Broad ]
GenevisibleExpression of HSPA9 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3313
GTEX Portal (Tissue expression)HSPA9
Human Protein AtlasENSG00000113013-HSPA9 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP38646   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP38646  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP38646
PhosPhoSitePlusP38646
Domaine pattern : Prosite (Expaxy)HSP70_1 (PS00297)    HSP70_2 (PS00329)    HSP70_3 (PS01036)   
Domains : Interpro (EBI)ATPase_NBD    Chaperone_DnaK    Heat_shock_70_CS    HSP70_C_sf    HSP70_peptide-bd_sf    Hsp_70_fam   
Domain families : Pfam (Sanger)HSP70 (PF00012)   
Domain families : Pfam (NCBI)pfam00012   
Conserved Domain (NCBI)HSPA9
PDB (RSDB)3N8E    4KBO    6NHK    6P2U    6PMT   
PDB Europe3N8E    4KBO    6NHK    6P2U    6PMT   
PDB (PDBSum)3N8E    4KBO    6NHK    6P2U    6PMT   
PDB (IMB)3N8E    4KBO    6NHK    6P2U    6PMT   
Structural Biology KnowledgeBase3N8E    4KBO    6NHK    6P2U    6PMT   
SCOP (Structural Classification of Proteins)3N8E    4KBO    6NHK    6P2U    6PMT   
CATH (Classification of proteins structures)3N8E    4KBO    6NHK    6P2U    6PMT   
SuperfamilyP38646
AlphaFold pdb e-kbP38646   
Human Protein Atlas [tissue]ENSG00000113013-HSPA9 [tissue]
HPRD02770
Protein Interaction databases
DIP (DOE-UCLA)P38646
IntAct (EBI)P38646
BioGRIDHSPA9
STRING (EMBL)HSPA9
ZODIACHSPA9
Ontologies - Pathways
QuickGOP38646
Ontology : AmiGOSAM complex  RNA binding  protein binding  ATP binding  nucleolus  cytoplasm  mitochondrion  mitochondrion  mitochondrion  mitochondrial matrix  focal adhesion  protein export from nucleus  inner mitochondrial membrane organization  iron-sulfur cluster assembly  ATPase  erythrocyte differentiation  heat shock protein binding  ubiquitin protein ligase binding  cellular response to unfolded protein  interleukin-12-mediated signaling pathway  protein refolding  mitochondrial nucleoid  negative regulation of apoptotic process  protein folding chaperone  regulation of erythrocyte differentiation  negative regulation of erythrocyte differentiation  unfolded protein binding  unfolded protein binding  chaperone cofactor-dependent protein refolding  misfolded protein binding  extracellular exosome  MIB complex  negative regulation of hematopoietic stem cell differentiation  negative regulation of hemopoiesis  
Ontology : EGO-EBISAM complex  RNA binding  protein binding  ATP binding  nucleolus  cytoplasm  mitochondrion  mitochondrion  mitochondrion  mitochondrial matrix  focal adhesion  protein export from nucleus  inner mitochondrial membrane organization  iron-sulfur cluster assembly  ATPase  erythrocyte differentiation  heat shock protein binding  ubiquitin protein ligase binding  cellular response to unfolded protein  interleukin-12-mediated signaling pathway  protein refolding  mitochondrial nucleoid  negative regulation of apoptotic process  protein folding chaperone  regulation of erythrocyte differentiation  negative regulation of erythrocyte differentiation  unfolded protein binding  unfolded protein binding  chaperone cofactor-dependent protein refolding  misfolded protein binding  extracellular exosome  MIB complex  negative regulation of hematopoietic stem cell differentiation  negative regulation of hemopoiesis  
Pathways : KEGGRNA degradation    Tuberculosis   
NDEx NetworkHSPA9
Atlas of Cancer Signalling NetworkHSPA9
Wikipedia pathwaysHSPA9
Orthology - Evolution
OrthoDB3313
GeneTree (enSembl)ENSG00000113013
Phylogenetic Trees/Animal Genes : TreeFamHSPA9
Homologs : HomoloGeneHSPA9
Homology/Alignments : Family Browser (UCSC)HSPA9
Gene fusions - Rearrangements
Fusion : MitelmanARF1/HSPA9 [1q42.13/5q31.2]  
Fusion : MitelmanHSPA9/ARL15 [5q31.2/5q11.2]  
Fusion : MitelmanTBC1D25/HSPA9 [Xp11.23/5q31.2]  
Fusion : QuiverHSPA9
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHSPA9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HSPA9
dbVarHSPA9
ClinVarHSPA9
MonarchHSPA9
1000_GenomesHSPA9 
Exome Variant ServerHSPA9
GNOMAD BrowserENSG00000113013
Varsome BrowserHSPA9
ACMGHSPA9 variants
VarityP38646
Genomic Variants (DGV)HSPA9 [DGVbeta]
DECIPHERHSPA9 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHSPA9 
Mutations
ICGC Data PortalHSPA9 
TCGA Data PortalHSPA9 
Broad Tumor PortalHSPA9
OASIS PortalHSPA9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHSPA9  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHSPA9
Mutations and Diseases : HGMDHSPA9
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHSPA9
DgiDB (Drug Gene Interaction Database)HSPA9
DoCM (Curated mutations)HSPA9
CIViC (Clinical Interpretations of Variants in Cancer)HSPA9
Cancer3DHSPA9
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182170    600548    616854   
Orphanet19831   
DisGeNETHSPA9
MedgenHSPA9
Genetic Testing Registry HSPA9
NextProtP38646 [Medical]
GENETestsHSPA9
Target ValidationHSPA9
Huge Navigator HSPA9 [HugePedia]
ClinGenHSPA9
Clinical trials, drugs, therapy
MyCancerGenomeHSPA9
Protein Interactions : CTDHSPA9
Pharm GKB GenePA162391712
PharosP38646
Clinical trialHSPA9
Miscellaneous
canSAR (ICR)HSPA9
HarmonizomeHSPA9
DataMed IndexHSPA9
Probes
Litterature
PubMed354 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHSPA9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:13:10 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.