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HSPA9 (heat shock protein family A (Hsp70) member 9)

Identity

Alias_namesHSPA9B
heat shock 70kDa protein 9B (mortalin-2)
heat shock 70kDa protein 9 (mortalin)
Alias_symbol (synonym)GRP75
PBP74
mot-2
mthsp75
Other aliasCRP40
CSA
EVPLS
GRP-75
HEL-S-124m
MOT
MOT2
MTHSP75
SAAN
SIDBA4
HGNC (Hugo) HSPA9
LocusID (NCBI) 3313
Atlas_Id 40879
Location 5q31.2  [Link to chromosome band 5q31]
Location_base_pair Starts at 138554882 and ends at 138575629 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARF1 (1q42.13) / HSPA9 (5q31.2)ARFRP1 (20q13.33) / HSPA9 (5q31.2)ARHGAP26 (5q31.3) / HSPA9 (5q31.2)
HSPA9 (5q31.2) / ARL15 (5q11.2)HSPA9 (5q31.2) / HSPA9 (5q31.2)HSPA9 (5q31.2) / NEFL (8p21.2)
HSPA9 (5q31.2) / RMND5B (5q35.3)HSPA9 (5q31.2) / RPS20 (8q12.1)HSPA9 (5q31.2) / SLC35A2 (Xp11.23)
HSPA9 (5q31.2) / TMCO6 (5q31.3)INA (10q24.33) / HSPA9 (5q31.2)MARCH6 (5p15.2) / HSPA9 (5q31.2)
TBC1D25 (Xp11.23) / HSPA9 (5q31.2)ZRANB1 (10q26.13) / HSPA9 (5q31.2)ARF1 1q42.13 / HSPA9 5q31.2
HSPA9 5q31.2 / ARL15 5q11.2TBC1D25 Xp11.23 / HSPA9 5q31.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HSPA9   5244
Cards
Entrez_Gene (NCBI)HSPA9  3313  heat shock protein family A (Hsp70) member 9
AliasesCRP40; CSA; EVPLS; GRP-75; 
GRP75; HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN; SIDBA4
GeneCards (Weizmann)HSPA9
Ensembl hg19 (Hinxton)ENSG00000113013 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113013 [Gene_View]  chr5:138554882-138575629 [Contig_View]  HSPA9 [Vega]
ICGC DataPortalENSG00000113013
TCGA cBioPortalHSPA9
AceView (NCBI)HSPA9
Genatlas (Paris)HSPA9
WikiGenes3313
SOURCE (Princeton)HSPA9
Genetics Home Reference (NIH)HSPA9
Genomic and cartography
GoldenPath hg38 (UCSC)HSPA9  -     chr5:138554882-138575629 -  5q31.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HSPA9  -     5q31.2   [Description]    (hg19-Feb_2009)
EnsemblHSPA9 - 5q31.2 [CytoView hg19]  HSPA9 - 5q31.2 [CytoView hg38]
Mapping of homologs : NCBIHSPA9 [Mapview hg19]  HSPA9 [Mapview hg38]
OMIM182170   600548   616854   
Gene and transcription
Genbank (Entrez)AK023317 AK222758 AK225488 AK293990 AK297795
RefSeq transcript (Entrez)NM_004134
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HSPA9
Cluster EST : UnigeneHs.184233 [ NCBI ]
CGAP (NCI)Hs.184233
Alternative Splicing GalleryENSG00000113013
Gene ExpressionHSPA9 [ NCBI-GEO ]   HSPA9 [ EBI - ARRAY_EXPRESS ]   HSPA9 [ SEEK ]   HSPA9 [ MEM ]
Gene Expression Viewer (FireBrowse)HSPA9 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3313
GTEX Portal (Tissue expression)HSPA9
Protein : pattern, domain, 3D structure
UniProt/SwissProtP38646   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP38646  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP38646
Splice isoforms : SwissVarP38646
PhosPhoSitePlusP38646
Domaine pattern : Prosite (Expaxy)HSP70_1 (PS00297)    HSP70_2 (PS00329)    HSP70_3 (PS01036)   
Domains : Interpro (EBI)Chaperone_DnaK    Heat_shock_70_CS    HSP70_C    HSP70_peptide-bd    Hsp_70_fam   
Domain families : Pfam (Sanger)HSP70 (PF00012)   
Domain families : Pfam (NCBI)pfam00012   
Conserved Domain (NCBI)HSPA9
DMDM Disease mutations3313
Blocks (Seattle)HSPA9
PDB (SRS)3N8E    4KBO   
PDB (PDBSum)3N8E    4KBO   
PDB (IMB)3N8E    4KBO   
PDB (RSDB)3N8E    4KBO   
Structural Biology KnowledgeBase3N8E    4KBO   
SCOP (Structural Classification of Proteins)3N8E    4KBO   
CATH (Classification of proteins structures)3N8E    4KBO   
SuperfamilyP38646
Human Protein AtlasENSG00000113013
Peptide AtlasP38646
HPRD02770
IPIIPI00007765   IPI00966238   IPI00922694   IPI00982199   IPI00966253   IPI00966508   IPI00967732   IPI00966795   IPI00977382   
Protein Interaction databases
DIP (DOE-UCLA)P38646
IntAct (EBI)P38646
FunCoupENSG00000113013
BioGRIDHSPA9
STRING (EMBL)HSPA9
ZODIACHSPA9
Ontologies - Pathways
QuickGOP38646
Ontology : AmiGORNA binding  protein binding  ATP binding  nucleolus  cytoplasm  mitochondrion  mitochondrion  focal adhesion  protein folding  protein export from nucleus  erythrocyte differentiation  extracellular matrix  ubiquitin protein ligase binding  mitochondrial nucleoid  negative regulation of apoptotic process  myelin sheath  negative regulation of erythrocyte differentiation  unfolded protein binding  extracellular exosome  negative regulation of hematopoietic stem cell differentiation  
Ontology : EGO-EBIRNA binding  protein binding  ATP binding  nucleolus  cytoplasm  mitochondrion  mitochondrion  focal adhesion  protein folding  protein export from nucleus  erythrocyte differentiation  extracellular matrix  ubiquitin protein ligase binding  mitochondrial nucleoid  negative regulation of apoptotic process  myelin sheath  negative regulation of erythrocyte differentiation  unfolded protein binding  extracellular exosome  negative regulation of hematopoietic stem cell differentiation  
Pathways : KEGGRNA degradation    Tuberculosis   
NDEx NetworkHSPA9
Atlas of Cancer Signalling NetworkHSPA9
Wikipedia pathwaysHSPA9
Orthology - Evolution
OrthoDB3313
GeneTree (enSembl)ENSG00000113013
Phylogenetic Trees/Animal Genes : TreeFamHSPA9
HOVERGENP38646
HOGENOMP38646
Homologs : HomoloGeneHSPA9
Homology/Alignments : Family Browser (UCSC)HSPA9
Gene fusions - Rearrangements
Fusion : MitelmanARF1/HSPA9 [1q42.13/5q31.2]  [t(1;5)(q42;q31)]  
Fusion : MitelmanHSPA9/ARL15 [5q31.2/5q11.2]  [t(5;5)(q11;q31)]  
Fusion : MitelmanTBC1D25/HSPA9 [Xp11.23/5q31.2]  [t(X;5)(p11;q31)]  
Fusion: TCGAARF1 1q42.13 HSPA9 5q31.2 PRAD
Fusion: TCGAHSPA9 5q31.2 ARL15 5q11.2 BRCA
Fusion: TCGATBC1D25 Xp11.23 HSPA9 5q31.2 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHSPA9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HSPA9
dbVarHSPA9
ClinVarHSPA9
1000_GenomesHSPA9 
Exome Variant ServerHSPA9
ExAC (Exome Aggregation Consortium)HSPA9 (select the gene name)
Genetic variants : HAPMAP3313
Genomic Variants (DGV)HSPA9 [DGVbeta]
DECIPHERHSPA9 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHSPA9 
Mutations
ICGC Data PortalHSPA9 
TCGA Data PortalHSPA9 
Broad Tumor PortalHSPA9
OASIS PortalHSPA9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHSPA9  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHSPA9
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch HSPA9
DgiDB (Drug Gene Interaction Database)HSPA9
DoCM (Curated mutations)HSPA9 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HSPA9 (select a term)
intoGenHSPA9
Cancer3DHSPA9(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182170    600548    616854   
Orphanet19831   
MedgenHSPA9
Genetic Testing Registry HSPA9
NextProtP38646 [Medical]
TSGene3313
GENETestsHSPA9
Target ValidationHSPA9
Huge Navigator HSPA9 [HugePedia]
snp3D : Map Gene to Disease3313
BioCentury BCIQHSPA9
ClinGenHSPA9
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3313
Chemical/Pharm GKB GenePA162391712
Clinical trialHSPA9
Miscellaneous
canSAR (ICR)HSPA9 (select the gene name)
Probes
Litterature
PubMed218 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHSPA9
EVEXHSPA9
GoPubMedHSPA9
iHOPHSPA9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:37:41 CEST 2017

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