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HSPB2 (heat shock protein family B (small) member 2)

Identity

Alias_namesheat shock 27kD protein 2
heat shock 27kDa protein 2
Alias_symbol (synonym)Hs.78846
MKBP
Other aliasHSP27
LOH11CR1K
HGNC (Hugo) HSPB2
LocusID (NCBI) 3316
Atlas_Id 40881
Location 11q23.1  [Link to chromosome band 11q23]
Location_base_pair Starts at 111912736 and ends at 111914093 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HSPB2 (11q23.1) / C11orf52 (11q23.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HSPB2   5247
Cards
Entrez_Gene (NCBI)HSPB2  3316  heat shock protein family B (small) member 2
AliasesHSP27; Hs.78846; LOH11CR1K; MKBP
GeneCards (Weizmann)HSPB2
Ensembl hg19 (Hinxton)ENSG00000170276 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170276 [Gene_View]  chr11:111912736-111914093 [Contig_View]  HSPB2 [Vega]
ICGC DataPortalENSG00000170276
TCGA cBioPortalHSPB2
AceView (NCBI)HSPB2
Genatlas (Paris)HSPB2
WikiGenes3316
SOURCE (Princeton)HSPB2
Genetics Home Reference (NIH)HSPB2
Genomic and cartography
GoldenPath hg38 (UCSC)HSPB2  -     chr11:111912736-111914093 +  11q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HSPB2  -     11q23.1   [Description]    (hg19-Feb_2009)
EnsemblHSPB2 - 11q23.1 [CytoView hg19]  HSPB2 - 11q23.1 [CytoView hg38]
Mapping of homologs : NCBIHSPB2 [Mapview hg19]  HSPB2 [Mapview hg38]
OMIM602179   
Gene and transcription
Genbank (Entrez)AB096250 AI131288 BC109393 CR457408 D89617
RefSeq transcript (Entrez)NM_001541
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HSPB2
Cluster EST : UnigeneHs.709660 [ NCBI ]
CGAP (NCI)Hs.709660
Alternative Splicing GalleryENSG00000170276
Gene ExpressionHSPB2 [ NCBI-GEO ]   HSPB2 [ EBI - ARRAY_EXPRESS ]   HSPB2 [ SEEK ]   HSPB2 [ MEM ]
Gene Expression Viewer (FireBrowse)HSPB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3316
GTEX Portal (Tissue expression)HSPB2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16082   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16082  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16082
Splice isoforms : SwissVarQ16082
PhosPhoSitePlusQ16082
Domaine pattern : Prosite (Expaxy)HSP20 (PS01031)   
Domains : Interpro (EBI)A-crystallin/Hsp20_dom    Alpha-crystallin/HSP    HSP20    HSP20-like_chaperone   
Domain families : Pfam (Sanger)HSP20 (PF00011)   
Domain families : Pfam (NCBI)pfam00011   
Conserved Domain (NCBI)HSPB2
DMDM Disease mutations3316
Blocks (Seattle)HSPB2
SuperfamilyQ16082
Human Protein AtlasENSG00000170276
Peptide AtlasQ16082
HPRD03712
IPIIPI00032195   IPI00979092   
Protein Interaction databases
DIP (DOE-UCLA)Q16082
IntAct (EBI)Q16082
FunCoupENSG00000170276
BioGRIDHSPB2
STRING (EMBL)HSPB2
ZODIACHSPB2
Ontologies - Pathways
QuickGOQ16082
Ontology : AmiGOprotein binding  nucleus  cytoplasm  cytosol  response to unfolded protein  enzyme activator activity  response to heat  positive regulation of catalytic activity  
Ontology : EGO-EBIprotein binding  nucleus  cytoplasm  cytosol  response to unfolded protein  enzyme activator activity  response to heat  positive regulation of catalytic activity  
Pathways : BIOCARTAp38 MAPK Signaling Pathway [Genes]    Stress Induction of HSP Regulation [Genes]    Downregulated of MTA-3 in ER-negative Breast Tumors [Genes]   
Pathways : KEGGEpstein-Barr virus infection    Proteoglycans in cancer   
NDEx NetworkHSPB2
Atlas of Cancer Signalling NetworkHSPB2
Wikipedia pathwaysHSPB2
Orthology - Evolution
OrthoDB3316
GeneTree (enSembl)ENSG00000170276
Phylogenetic Trees/Animal Genes : TreeFamHSPB2
HOVERGENQ16082
HOGENOMQ16082
Homologs : HomoloGeneHSPB2
Homology/Alignments : Family Browser (UCSC)HSPB2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHSPB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HSPB2
dbVarHSPB2
ClinVarHSPB2
1000_GenomesHSPB2 
Exome Variant ServerHSPB2
ExAC (Exome Aggregation Consortium)HSPB2 (select the gene name)
Genetic variants : HAPMAP3316
Genomic Variants (DGV)HSPB2 [DGVbeta]
DECIPHERHSPB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHSPB2 
Mutations
ICGC Data PortalHSPB2 
TCGA Data PortalHSPB2 
Broad Tumor PortalHSPB2
OASIS PortalHSPB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHSPB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHSPB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HSPB2
DgiDB (Drug Gene Interaction Database)HSPB2
DoCM (Curated mutations)HSPB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HSPB2 (select a term)
intoGenHSPB2
Cancer3DHSPB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602179   
Orphanet
MedgenHSPB2
Genetic Testing Registry HSPB2
NextProtQ16082 [Medical]
TSGene3316
GENETestsHSPB2
Target ValidationHSPB2
Huge Navigator HSPB2 [HugePedia]
snp3D : Map Gene to Disease3316
BioCentury BCIQHSPB2
ClinGenHSPB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3316
Chemical/Pharm GKB GenePA29512
Clinical trialHSPB2
Miscellaneous
canSAR (ICR)HSPB2 (select the gene name)
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHSPB2
EVEXHSPB2
GoPubMedHSPB2
iHOPHSPB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:03:32 CEST 2017

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