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HSPB3 (heat shock protein family B (small) member 3)

Identity

Alias_namesheat shock 27kD protein 3
heat shock 27kDa protein 3
Alias_symbol (synonym)HSPL27
Other aliasDHMN2C
HMN2C
HGNC (Hugo) HSPB3
LocusID (NCBI) 8988
Atlas_Id 47490
Location 5q11.2  [Link to chromosome band 5q11]
Location_base_pair Starts at 54455601 and ends at 54456384 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HSPB3   5248
Cards
Entrez_Gene (NCBI)HSPB3  8988  heat shock protein family B (small) member 3
AliasesDHMN2C; HMN2C; HSPL27
GeneCards (Weizmann)HSPB3
Ensembl hg19 (Hinxton)ENSG00000169271 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169271 [Gene_View]  chr5:54455601-54456384 [Contig_View]  HSPB3 [Vega]
ICGC DataPortalENSG00000169271
TCGA cBioPortalHSPB3
AceView (NCBI)HSPB3
Genatlas (Paris)HSPB3
WikiGenes8988
SOURCE (Princeton)HSPB3
Genetics Home Reference (NIH)HSPB3
Genomic and cartography
GoldenPath hg38 (UCSC)HSPB3  -     chr5:54455601-54456384 +  5q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HSPB3  -     5q11.2   [Description]    (hg19-Feb_2009)
EnsemblHSPB3 - 5q11.2 [CytoView hg19]  HSPB3 - 5q11.2 [CytoView hg38]
Mapping of homologs : NCBIHSPB3 [Mapview hg19]  HSPB3 [Mapview hg38]
OMIM604624   613376   
Gene and transcription
Genbank (Entrez)AK314215 BC126272 BC132869 BX106905 CR450314
RefSeq transcript (Entrez)NM_006308
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HSPB3
Cluster EST : UnigeneHs.41707 [ NCBI ]
CGAP (NCI)Hs.41707
Alternative Splicing GalleryENSG00000169271
Gene ExpressionHSPB3 [ NCBI-GEO ]   HSPB3 [ EBI - ARRAY_EXPRESS ]   HSPB3 [ SEEK ]   HSPB3 [ MEM ]
Gene Expression Viewer (FireBrowse)HSPB3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8988
GTEX Portal (Tissue expression)HSPB3
Human Protein AtlasENSG00000169271-HSPB3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12988   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ12988  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12988
Splice isoforms : SwissVarQ12988
PhosPhoSitePlusQ12988
Domaine pattern : Prosite (Expaxy)HSP20 (PS01031)   
Domains : Interpro (EBI)A-crystallin/Hsp20_dom    Alpha-crystallin/HSP    HSP20    HSP20-like_chaperone    HSPB3   
Domain families : Pfam (Sanger)HSP20 (PF00011)   
Domain families : Pfam (NCBI)pfam00011   
Conserved Domain (NCBI)HSPB3
DMDM Disease mutations8988
Blocks (Seattle)HSPB3
SuperfamilyQ12988
Human Protein Atlas [tissue]ENSG00000169271-HSPB3 [tissue]
Peptide AtlasQ12988
HPRD06861
IPIIPI00030405   
Protein Interaction databases
DIP (DOE-UCLA)Q12988
IntAct (EBI)Q12988
FunCoupENSG00000169271
BioGRIDHSPB3
STRING (EMBL)HSPB3
ZODIACHSPB3
Ontologies - Pathways
QuickGOQ12988
Ontology : AmiGOnucleus  cytoplasm  response to unfolded protein  nuclear speck  
Ontology : EGO-EBInucleus  cytoplasm  response to unfolded protein  nuclear speck  
NDEx NetworkHSPB3
Atlas of Cancer Signalling NetworkHSPB3
Wikipedia pathwaysHSPB3
Orthology - Evolution
OrthoDB8988
GeneTree (enSembl)ENSG00000169271
Phylogenetic Trees/Animal Genes : TreeFamHSPB3
HOVERGENQ12988
HOGENOMQ12988
Homologs : HomoloGeneHSPB3
Homology/Alignments : Family Browser (UCSC)HSPB3
Gene fusions - Rearrangements
Tumor Fusion PortalHSPB3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHSPB3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HSPB3
dbVarHSPB3
ClinVarHSPB3
1000_GenomesHSPB3 
Exome Variant ServerHSPB3
ExAC (Exome Aggregation Consortium)ENSG00000169271
GNOMAD BrowserENSG00000169271
Genetic variants : HAPMAP8988
Genomic Variants (DGV)HSPB3 [DGVbeta]
DECIPHERHSPB3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHSPB3 
Mutations
ICGC Data PortalHSPB3 
TCGA Data PortalHSPB3 
Broad Tumor PortalHSPB3
OASIS PortalHSPB3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHSPB3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHSPB3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HSPB3
DgiDB (Drug Gene Interaction Database)HSPB3
DoCM (Curated mutations)HSPB3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HSPB3 (select a term)
intoGenHSPB3
Cancer3DHSPB3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604624    613376   
Orphanet16915   
DisGeNETHSPB3
MedgenHSPB3
Genetic Testing Registry HSPB3
NextProtQ12988 [Medical]
TSGene8988
GENETestsHSPB3
Target ValidationHSPB3
Huge Navigator HSPB3 [HugePedia]
snp3D : Map Gene to Disease8988
BioCentury BCIQHSPB3
ClinGenHSPB3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8988
Chemical/Pharm GKB GenePA29513
Clinical trialHSPB3
Miscellaneous
canSAR (ICR)HSPB3 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHSPB3
EVEXHSPB3
GoPubMedHSPB3
iHOPHSPB3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:17:02 CET 2017

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