HSPB6 (heat shock protein family B (small) member 6)

2007-04-01  

Identity

HGNC
HSPB6
LOCATION
19q13.12
LOCUSID
126393
ALIAS
HEL55,Hsp20,PPP1R91

Other Information

Locus ID:

NCBI: 126393
MIM: 610695
HGNC: 26511
Ensembl: ENSG00000004776

Variants:

dbSNP: 126393
ClinVar: 126393
TCGA: ENSG00000004776
COSMIC: HSPB6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000004776ENST00000004982O14558
ENSG00000004776ENST00000004982V9HWB6
ENSG00000004776ENST00000587965K7EP04
ENSG00000004776ENST00000592984A0A1X7SC65

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
196469952009Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20.107
194911932009Genome-wide screen of promoter methylation identifies novel markers in melanoma.83
198455072009Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction.55
198509432009Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death.42
216419132011Three-dimensional structure of α-crystallin domain dimers of human small heat shock proteins HSPB1 and HSPB6.39
224278802012Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2.35
217316112011HSPB1, HSPB6, HSPB7 and HSPB8 protect against RhoA GTPase-induced remodeling in tachypaced atrial myocytes.33
218037752011Acetylation of heat shock protein 20 (Hsp20) regulates human myometrial activity.27
162258512005Interactions of HSP22 (HSPB8) with HSP20, alphaB-crystallin, and HSPB3.26
280894482017Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator.26

Citation

Dessen P

HSPB6 (heat shock protein family B (small) member 6)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47431/hspb6