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HSPE1 (heat shock protein family E (Hsp10) member 1)

Identity

Alias_namesheat shock 10kD protein 1 (chaperonin 10)
heat shock 10kDa protein 1
Alias_symbol (synonym)CPN10
GroES
HSP10
EPF
Other aliasGROES
HGNC (Hugo) HSPE1
LocusID (NCBI) 3336
Atlas_Id 40889
Location 2q33.1  [Link to chromosome band 2q33]
Location_base_pair Starts at 197499997 and ends at 197503463 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		HSPE1 (2q33.1) / MOB4 (2q33.1)HSPE1 (2q33.1) / TMPRSS7 (3q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)HSPE1   5269
Cards
Entrez_Gene (NCBI)HSPE1  3336  heat shock protein family E (Hsp10) member 1
AliasesCPN10; EPF; GROES; HSP10
GeneCards (Weizmann)HSPE1
Ensembl hg19 (Hinxton)ENSG00000115541 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115541 [Gene_View]  chr2:197499997-197503463 [Contig_View]  HSPE1 [Vega]
ICGC DataPortalENSG00000115541
TCGA cBioPortalHSPE1
AceView (NCBI)HSPE1
Genatlas (Paris)HSPE1
WikiGenes3336
SOURCE (Princeton)HSPE1
Genetics Home Reference (NIH)HSPE1
Genomic and cartography
GoldenPath hg38 (UCSC)HSPE1  -     chr2:197499997-197503463 +  2q33.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HSPE1  -     2q33.1   [Description]    (hg19-Feb_2009)
EnsemblHSPE1 - 2q33.1 [CytoView hg19]  HSPE1 - 2q33.1 [CytoView hg38]
Mapping of homologs : NCBIHSPE1 [Mapview hg19]  HSPE1 [Mapview hg38]
OMIM600141   
Gene and transcription
Genbank (Entrez)AK312104 BC023518 BG188453 CN264788 CR407688
RefSeq transcript (Entrez)NM_002157
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HSPE1
Cluster EST : UnigeneHs.1197 [ NCBI ]
CGAP (NCI)Hs.1197
Alternative Splicing GalleryENSG00000115541
Gene ExpressionHSPE1 [ NCBI-GEO ]   HSPE1 [ EBI - ARRAY_EXPRESS ]   HSPE1 [ SEEK ]   HSPE1 [ MEM ]
Gene Expression Viewer (FireBrowse)HSPE1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3336
GTEX Portal (Tissue expression)HSPE1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61604   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61604  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61604
Splice isoforms : SwissVarP61604
PhosPhoSitePlusP61604
Domaine pattern : Prosite (Expaxy)CHAPERONINS_CPN10 (PS00681)   
Domains : Interpro (EBI)Chaperonin_GroES    Chaprnonin_Cpn10_CS    GroES-like   
Domain families : Pfam (Sanger)Cpn10 (PF00166)   
Domain families : Pfam (NCBI)pfam00166   
Domain families : Smart (EMBL)Cpn10 (SM00883)  
Conserved Domain (NCBI)HSPE1
DMDM Disease mutations3336
Blocks (Seattle)HSPE1
PDB (SRS)4PJ1   
PDB (PDBSum)4PJ1   
PDB (IMB)4PJ1   
PDB (RSDB)4PJ1   
Structural Biology KnowledgeBase4PJ1   
SCOP (Structural Classification of Proteins)4PJ1   
CATH (Classification of proteins structures)4PJ1   
SuperfamilyP61604
Human Protein AtlasENSG00000115541
Peptide AtlasP61604
HPRD02535
IPIIPI00220362   IPI00916345   IPI00916763   
Protein Interaction databases
DIP (DOE-UCLA)P61604
IntAct (EBI)P61604
FunCoupENSG00000115541
BioGRIDHSPE1
STRING (EMBL)HSPE1
ZODIACHSPE1
Ontologies - Pathways
QuickGOP61604
Ontology : AmiGOosteoblast differentiation  RNA binding  protein binding  ATP binding  mitochondrion  mitochondrion  mitochondrial matrix  protein folding  activation of cysteine-type endopeptidase activity involved in apoptotic process  response to unfolded protein  membrane  metal ion binding  unfolded protein binding  unfolded protein binding  chaperone mediated protein folding requiring cofactor  chaperone binding  chaperone binding  extracellular exosome  
Ontology : EGO-EBIosteoblast differentiation  RNA binding  protein binding  ATP binding  mitochondrion  mitochondrion  mitochondrial matrix  protein folding  activation of cysteine-type endopeptidase activity involved in apoptotic process  response to unfolded protein  membrane  metal ion binding  unfolded protein binding  unfolded protein binding  chaperone mediated protein folding requiring cofactor  chaperone binding  chaperone binding  extracellular exosome  
NDEx NetworkHSPE1
Atlas of Cancer Signalling NetworkHSPE1
Wikipedia pathwaysHSPE1
Orthology - Evolution
OrthoDB3336
GeneTree (enSembl)ENSG00000115541
Phylogenetic Trees/Animal Genes : TreeFamHSPE1
HOVERGENP61604
HOGENOMP61604
Homologs : HomoloGeneHSPE1
Homology/Alignments : Family Browser (UCSC)HSPE1
Gene fusions - Rearrangements
Fusion : MitelmanHSPE1/MOB4 [2q33.1/2q33.1]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHSPE1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HSPE1
dbVarHSPE1
ClinVarHSPE1
1000_GenomesHSPE1 
Exome Variant ServerHSPE1
ExAC (Exome Aggregation Consortium)HSPE1 (select the gene name)
Genetic variants : HAPMAP3336
Genomic Variants (DGV)HSPE1 [DGVbeta]
DECIPHERHSPE1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHSPE1 
Mutations
ICGC Data PortalHSPE1 
TCGA Data PortalHSPE1 
Broad Tumor PortalHSPE1
OASIS PortalHSPE1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHSPE1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHSPE1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch HSPE1
DgiDB (Drug Gene Interaction Database)HSPE1
DoCM (Curated mutations)HSPE1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HSPE1 (select a term)
intoGenHSPE1
Cancer3DHSPE1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600141   
Orphanet
MedgenHSPE1
Genetic Testing Registry HSPE1
NextProtP61604 [Medical]
TSGene3336
GENETestsHSPE1
Target ValidationHSPE1
Huge Navigator HSPE1 [HugePedia]
snp3D : Map Gene to Disease3336
BioCentury BCIQHSPE1
ClinGenHSPE1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3336
Chemical/Pharm GKB GenePA29535
Clinical trialHSPE1
Miscellaneous
canSAR (ICR)HSPE1 (select the gene name)
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHSPE1
EVEXHSPE1
GoPubMedHSPE1
iHOPHSPE1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:12:32 CEST 2017
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