Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

HSPH1 (heat shock 105kDa/110kDa protein 1)

Written2007-02Takumi Hatayama, Nobuyuki Yamagishi
Department of Biochemistry, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607-8414, Japan

(Note : for Links provided by Atlas : click)

Identity

Alias_namesheat shock 105kDa/110kDa protein 1
Alias_symbol (synonym)HSP105B
KIAA0201
HSP105A
NY-CO-25
Other aliasHSP105 alpha
HSP105 bet
HSP110
HSP105
HGNC (Hugo) HSPH1
LocusID (NCBI) 10808
Atlas_Id 40891
Location 13q12.3  [Link to chromosome band 13q12]
Location_base_pair Starts at 31134974 and ends at 31162021 bp from pter ( according to hg19-Feb_2009)  [Mapping HSPH1.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ASXL2 (2p23.3) / HSPH1 (13q12.3)CCNE2 (8q22.1) / HSPH1 (13q12.3)HSPH1 (13q12.3) / DDX27 (20q13.13)
HSPH1 (13q12.3) / HSPH1 (13q12.3)HSPH1 (13q12.3) / PLEKHA5 (12p12.3)HSPH1 (13q12.3) / USPL1 (13q12.3)
KIAA0825 (5q15) / HSPH1 (13q12.3)PLS3 (Xq23) / HSPH1 (13q12.3)RMDN1 (8q21.3) / HSPH1 (13q12.3)
ULK2 (17p11.2) / HSPH1 (13q12.3)

DNA/RNA

 
  Genomic organization of the mouse HSP105 gene. The linear map of the exon-intron structure is shown schematically. Exons are represented as numbered boxes. Two alternative splicing patterns gave rise to HSP105alpha and HSP105beta transcripts. ATG and TAG indicate the positions of initiation and termination codons, respectively. (DDBJ/EMBL/GenBank DNA databases with accession Nos. AB005267-AB005282).
Description 18 exons on 22 kb
Transcription Hsp105alpha is transcribed constitutively and also by a variety of stresses. 4 kb mRNA Hsp105beta is an alternative spliced isoform only produced during heat shock at 42 degree.

Protein

 
  Shematic structures of HSP105alpha and HSP105beta proteins. Shaded box represents the spliced out region of HSP105alpha which is lacking in HSP105beta.
Description Hsp105alpha: 858 amino acids, 105 kDa; contains an ATP binding domain (residues 1-383), b-sheet domain (residues 384-511), loop domain (residues 512-607) and alpha-helix domain (residues 608-858). Hsp105beta: 814 amino acids, 90 kDa; contains an ATP binding domain (residues 1-383), b-sheet domain (residues 384-511), loop domain (residues 512-563) and alpha-helix domain (residues 564-814).
Expression wide, highly expressed in brain
Localisation Hsp105alpha, cytoplasmic; Hsp105beta, nuclear
Function Hsp105alpha and Hsp105beta suppress the aggregation of denatured proteins; function as a substitute for Hsp70 family proteins to suppress the aggregation of denatured proteins in cells under severe stress; regulate substrate binding cycle of Hsp70/Hsc70 by inhibiting the ATPase activity of Hsp70/Hsc70.
Homology With mouse apg-1, mouse apg-2, sea urchin egg receptor, C. elegans 86.9-kDa protein, A. thaliana hsp91 and S. cerevisiae SSE1, human hsp70 and human hsc70.

Implicated in

Note
  
Entity Lung cancers
Prognosis Poor
Oncogenesis Low expression of hsp105 was identified as predictors of survival in lung adenocarcinomas.
  
  
Entity Colorectal cancers
Prognosis Survival is not much more than 50% after 5 years.
Oncogenesis Overexpression of hsp105 is a late event in the colorectal adenoma-carcinoma sequence.
  

Bibliography

Synthetic small interfering RNA targeting heat shock protein 105 induces apoptosis of various cancer cells both in vitro and in vivo.
Hosaka S, Nakatsura T, Tsukamoto H, Hatayama T, Baba H, Nishimura Y
Cancer science. 2006 ; 97 (7) : 623-632.
PMID 16827803
 
Molecular cloning, expression and localization of human 105 kDa heat shock protein, hsp105.
Ishihara K, Yasuda K, Hatayama T
Biochimica et biophysica acta. 1999 ; 1444 (1) : 138-142.
PMID 9931472
 
Heat shock protein 105 is overexpressed in a variety of human tumors.
Kai M, Nakatsura T, Egami H, Senju S, Nishimura Y, Ogawa M
Oncology reports. 2003 ; 10 (6) : 1777-1782.
PMID 14534695
 
DNA vaccination of HSP105 leads to tumor rejection of colorectal cancer and melanoma in mice through activation of both CD4 T cells and CD8 T cells.
Miyazaki M, Nakatsura T, Yokomine K, Senju S, Monji M, Hosaka S, Komori H, Yoshitake Y, Motomura Y, Minohara M, Kubo T, Ishihara K, Hatayama T, Ogawa M, Nishimura Y
Cancer science. 2005 ; 96 (10) : 695-705.
PMID 16232202
 
Heat shock protein 105 is overexpressed in squamous cell carcinoma and extramammary Paget disease but not in basal cell carcinoma.
Muchemwa FC, Nakatsura T, Ihn H, Kageshita T
The British journal of dermatology. 2006 ; 155 (3) : 582-585.
PMID 16911285
 
Gene cloning of immunogenic antigens overexpressed in pancreatic cancer.
Nakatsura T, Senju S, Yamada K, Jotsuka T, Ogawa M, Nishimura Y
Biochemical and biophysical research communications. 2001 ; 281 (4) : 936-944.
PMID 11237751
 
Hsp105 family proteins suppress staurosporine-induced apoptosis by inhibiting the translocation of Bax to mitochondria in HeLa cells.
Yamagishi N, Ishihara K, Saito Y, Hatayama T
Experimental cell research. 2006 ; 312 (17) : 3215-3223.
PMID 16857185
 
Genomic cloning and promoter analysis of the mouse 105-kDa heat shock protein (HSP105) gene.
Yasuda K, Ishihara K, Nakashima K, Hatayama T
Biochemical and biophysical research communications. 1999 ; 256 (1) : 75-80.
PMID 10066425
 
Cloning and expression of murine high molecular mass heat shock proteins, HSP105.
Yasuda K, Nakai A, Hatayama T, Nagata K
The Journal of biological chemistry. 1995 ; 270 (50) : 29718-29723.
PMID 8530361
 

Citation

This paper should be referenced as such :
Yamagishi, N ; Hatayama, T
HSPH1 (heat shock 105kDa/110kDa protein 1)
Atlas Genet Cytogenet Oncol Haematol. 2007;11(3):197-198.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/HSPH1ID40891ch13q12.html


External links

Nomenclature
HGNC (Hugo)HSPH1   16969
Cards
AtlasHSPH1ID40891ch13q12
Entrez_Gene (NCBI)HSPH1  10808  heat shock protein family H (Hsp110) member 1
AliasesHSP105; HSP105A; HSP105B; NY-CO-25
GeneCards (Weizmann)HSPH1
Ensembl hg19 (Hinxton)ENSG00000120694 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120694 [Gene_View]  chr13:31134974-31162021 [Contig_View]  HSPH1 [Vega]
ICGC DataPortalENSG00000120694
TCGA cBioPortalHSPH1
AceView (NCBI)HSPH1
Genatlas (Paris)HSPH1
WikiGenes10808
SOURCE (Princeton)HSPH1
Genetics Home Reference (NIH)HSPH1
Genomic and cartography
GoldenPath hg38 (UCSC)HSPH1  -     chr13:31134974-31162021 -  13q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HSPH1  -     13q12.3   [Description]    (hg19-Feb_2009)
EnsemblHSPH1 - 13q12.3 [CytoView hg19]  HSPH1 - 13q12.3 [CytoView hg38]
Mapping of homologs : NCBIHSPH1 [Mapview hg19]  HSPH1 [Mapview hg38]
OMIM610703   
Gene and transcription
Genbank (Entrez)AB003333 AB003334 AF039695 AK293955 AK302294
RefSeq transcript (Entrez)NM_001286503 NM_001286504 NM_001286505 NM_001349704 NM_006644
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HSPH1
Cluster EST : UnigeneHs.743267 [ NCBI ]
CGAP (NCI)Hs.743267
Alternative Splicing GalleryENSG00000120694
Gene ExpressionHSPH1 [ NCBI-GEO ]   HSPH1 [ EBI - ARRAY_EXPRESS ]   HSPH1 [ SEEK ]   HSPH1 [ MEM ]
Gene Expression Viewer (FireBrowse)HSPH1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10808
GTEX Portal (Tissue expression)HSPH1
Human Protein AtlasENSG00000120694-HSPH1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92598   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92598  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92598
Splice isoforms : SwissVarQ92598
PhosPhoSitePlusQ92598
Domaine pattern : Prosite (Expaxy)HSP70_3 (PS01036)   
Domains : Interpro (EBI)Heat_shock_70_CS    HSP70_C    HSP70_peptide-bd    Hsp_70_fam   
Domain families : Pfam (Sanger)HSP70 (PF00012)   
Domain families : Pfam (NCBI)pfam00012   
Conserved Domain (NCBI)HSPH1
DMDM Disease mutations10808
Blocks (Seattle)HSPH1
SuperfamilyQ92598
Human Protein Atlas [tissue]ENSG00000120694-HSPH1 [tissue]
Peptide AtlasQ92598
HPRD09990
IPIIPI00939163   IPI00218993   IPI00513743   IPI00908988   IPI00514983   IPI00910755   IPI00910341   IPI00794417   
Protein Interaction databases
DIP (DOE-UCLA)Q92598
IntAct (EBI)Q92598
FunCoupENSG00000120694
BioGRIDHSPH1
STRING (EMBL)HSPH1
ZODIACHSPH1
Ontologies - Pathways
QuickGOQ92598
Ontology : AmiGOadenyl-nucleotide exchange factor activity  adenyl-nucleotide exchange factor activity  protein binding  ATP binding  extracellular region  nucleoplasm  cytoplasm  cytosol  cytosol  microtubule  receptor-mediated endocytosis  response to unfolded protein  alpha-tubulin binding  positive regulation of MHC class I biosynthetic process  positive regulation of transcription from RNA polymerase II promoter  chaperone mediated protein folding requiring cofactor  positive regulation of NK T cell activation  positive regulation of protein tyrosine kinase activity  extracellular exosome  endocytic vesicle lumen  regulation of cellular response to heat  negative regulation of establishment of protein localization to mitochondrion  negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide  negative regulation of p38MAPK cascade  
Ontology : EGO-EBIadenyl-nucleotide exchange factor activity  adenyl-nucleotide exchange factor activity  protein binding  ATP binding  extracellular region  nucleoplasm  cytoplasm  cytosol  cytosol  microtubule  receptor-mediated endocytosis  response to unfolded protein  alpha-tubulin binding  positive regulation of MHC class I biosynthetic process  positive regulation of transcription from RNA polymerase II promoter  chaperone mediated protein folding requiring cofactor  positive regulation of NK T cell activation  positive regulation of protein tyrosine kinase activity  extracellular exosome  endocytic vesicle lumen  regulation of cellular response to heat  negative regulation of establishment of protein localization to mitochondrion  negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide  negative regulation of p38MAPK cascade  
Pathways : KEGGProtein processing in endoplasmic reticulum   
REACTOMEQ92598 [protein]
REACTOME PathwaysR-HSA-3371453 [pathway]   
NDEx NetworkHSPH1
Atlas of Cancer Signalling NetworkHSPH1
Wikipedia pathwaysHSPH1
Orthology - Evolution
OrthoDB10808
GeneTree (enSembl)ENSG00000120694
Phylogenetic Trees/Animal Genes : TreeFamHSPH1
HOVERGENQ92598
HOGENOMQ92598
Homologs : HomoloGeneHSPH1
Homology/Alignments : Family Browser (UCSC)HSPH1
Gene fusions - Rearrangements
Fusion : MitelmanASXL2/HSPH1 [2p23.3/13q12.3]  [t(2;13)(p23;q12)]  
Fusion : MitelmanHSPH1/DDX27 [13q12.3/20q13.13]  [t(13;20)(q12;q13)]  
Fusion : MitelmanHSPH1/PLEKHA5 [13q12.3/12p12.3]  [t(12;13)(p12;q12)]  
Fusion : MitelmanKIAA0825/HSPH1 [5q15/13q12.3]  [t(5;13)(q15;q12)]  
Fusion: TCGAASXL2 2p23.3 HSPH1 13q12.3 BRCA
Fusion: TCGAHSPH1 13q12.3 DDX27 20q13.13 LGG
Fusion: TCGAHSPH1 13q12.3 PLEKHA5 12p12.3 HNSC
Fusion: TCGAKIAA0825 5q15 HSPH1 13q12.3 BRCA
Fusion Cancer (Beijing)AD_1 [-PH1]  -  13q12.3 [FUSC000338]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHSPH1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HSPH1
dbVarHSPH1
ClinVarHSPH1
1000_GenomesHSPH1 
Exome Variant ServerHSPH1
ExAC (Exome Aggregation Consortium)ENSG00000120694
GNOMAD BrowserENSG00000120694
Genetic variants : HAPMAP10808
Genomic Variants (DGV)HSPH1 [DGVbeta]
DECIPHERHSPH1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHSPH1 
Mutations
ICGC Data PortalHSPH1 
TCGA Data PortalHSPH1 
Broad Tumor PortalHSPH1
OASIS PortalHSPH1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHSPH1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHSPH1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HSPH1
DgiDB (Drug Gene Interaction Database)HSPH1
DoCM (Curated mutations)HSPH1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HSPH1 (select a term)
intoGenHSPH1
NCG5 (London)HSPH1
Cancer3DHSPH1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610703   
Orphanet
MedgenHSPH1
Genetic Testing Registry HSPH1
NextProtQ92598 [Medical]
TSGene10808
GENETestsHSPH1
Target ValidationHSPH1
Huge Navigator HSPH1 [HugePedia]
snp3D : Map Gene to Disease10808
BioCentury BCIQHSPH1
ClinGenHSPH1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10808
Chemical/Pharm GKB GenePA134869917
Clinical trialHSPH1
Miscellaneous
canSAR (ICR)HSPH1 (select the gene name)
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHSPH1
EVEXHSPH1
GoPubMedHSPH1
iHOPHSPH1
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Oct 12 16:24:16 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.