HTN1 (histatin 1)

2017-10-01  

Identity

HGNC
LOCATION
4q13.3
LOCUSID
ALIAS
HIS1
FUSION GENES

Other Information

Locus ID:

NCBI: 3346
MIM: 142701
HGNC: 5283
Ensembl: ENSG00000126550

Variants:

dbSNP: 3346
ClinVar: 3346
TCGA: ENSG00000126550
COSMIC: HTN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126550ENST00000246896P15515
ENSG00000126550ENST00000511674P15515
ENSG00000126550ENST00000610341P15515

Expression (GTEx)

0
1
2
3

Pathways

PathwaySourceExternal ID
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Antimicrobial peptidesREACTOMER-HSA-6803157

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
186502432008Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay.38
23035951990Structural relationship between human salivary histatins.28
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
175037972007Tyrosine polysulfation of human salivary histatin 1. A post-translational modification specific of the submandibular gland.8
287515262017The salivary peptide histatin-1 promotes endothelial cell adhesion, migration, and angiogenesis.7
230018802012Identification and characterization of histatin 1 salivary complexes by using mass spectrometry.6
268248962016Histatin-1 Expression in Human Lacrimal Epithelium.5
285225952017Human salivary peptide histatin-1 stimulates epithelial and endothelial cell adhesion and barrier function.3
120608662002Comparison of inhibitory activity on calcium phosphate precipitation by acidic proline-rich proteins, statherin, and histatin-1.1
190603112009Transcriptional regulation of the salivary histatin gene: finding of a strong positive regulatory element and its binding protein.1

Citation

Dessen P

HTN1 (histatin 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57190/htn1