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HTN3 (histatin 3)

Identity

Alias_symbol (synonym)HIS2
Other aliasHTN2
HTN5
HGNC (Hugo) HTN3
LocusID (NCBI) 3347
Atlas_Id 51767
Location 4q13.3  [Link to chromosome band 4q13]
Location_base_pair Starts at 70894130 and ends at 70902255 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CGNL1 (15q21.3) / HTN3 (4q13.3)CSNK1G3 (5q23.2) / HTN3 (4q13.3)DAB2IP (9q33.2) / HTN3 (4q13.3)
HTN3 (4q13.3) / OSBPL1A (18q11.2)HTN3 (4q13.3) / RIMS1 (6q13)HTN3 (4q13.3) / RPL6 (12q24.13)
KCNE2 (21q22.11) / HTN3 (4q13.3)DAB2IP 9q33.2 / HTN3 4q13.3KCNE2 21q22.11 / HTN3 4q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HTN3   5284
Cards
Entrez_Gene (NCBI)HTN3  3347  histatin 3
AliasesHIS2; HTN2; HTN5
GeneCards (Weizmann)HTN3
Ensembl hg19 (Hinxton)ENSG00000205649 [Gene_View]  chr4:70894130-70902255 [Contig_View]  HTN3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000205649 [Gene_View]  chr4:70894130-70902255 [Contig_View]  HTN3 [Vega]
ICGC DataPortalENSG00000205649
TCGA cBioPortalHTN3
AceView (NCBI)HTN3
Genatlas (Paris)HTN3
WikiGenes3347
SOURCE (Princeton)HTN3
Genetics Home Reference (NIH)HTN3
Genomic and cartography
GoldenPath hg19 (UCSC)HTN3  -     chr4:70894130-70902255 +  4q13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HTN3  -     4q13.3   [Description]    (hg38-Dec_2013)
EnsemblHTN3 - 4q13.3 [CytoView hg19]  HTN3 - 4q13.3 [CytoView hg38]
Mapping of homologs : NCBIHTN3 [Mapview hg19]  HTN3 [Mapview hg38]
OMIM142702   
Gene and transcription
Genbank (Entrez)BC009791 BC095438 BP332860 CB957931 DQ892864
RefSeq transcript (Entrez)NM_000200
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_012279 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)HTN3
Cluster EST : UnigeneHs.654442 [ NCBI ]
CGAP (NCI)Hs.654442
Alternative Splicing GalleryENSG00000205649
Gene ExpressionHTN3 [ NCBI-GEO ]   HTN3 [ EBI - ARRAY_EXPRESS ]   HTN3 [ SEEK ]   HTN3 [ MEM ]
Gene Expression Viewer (FireBrowse)HTN3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3347
GTEX Portal (Tissue expression)HTN3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15516   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP15516  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP15516
Splice isoforms : SwissVarP15516
PhosPhoSitePlusP15516
Domains : Interpro (EBI)Histatin-3    Histatin/statherin   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)HTN3
DMDM Disease mutations3347
Blocks (Seattle)HTN3
SuperfamilyP15516
Human Protein AtlasENSG00000205649
Peptide AtlasP15516
HPRD00815
IPIIPI00012026   IPI00980807   
Protein Interaction databases
DIP (DOE-UCLA)P15516
IntAct (EBI)P15516
FunCoupENSG00000205649
BioGRIDHTN3
STRING (EMBL)HTN3
ZODIACHTN3
Ontologies - Pathways
QuickGOP15516
Ontology : AmiGOprotein binding  extracellular region  biomineral tissue development  killing of cells of other organism  defense response to bacterium  metal ion binding  defense response to fungus  
Ontology : EGO-EBIprotein binding  extracellular region  biomineral tissue development  killing of cells of other organism  defense response to bacterium  metal ion binding  defense response to fungus  
Pathways : KEGGSalivary secretion   
NDEx NetworkHTN3
Atlas of Cancer Signalling NetworkHTN3
Wikipedia pathwaysHTN3
Orthology - Evolution
OrthoDB3347
GeneTree (enSembl)ENSG00000205649
Phylogenetic Trees/Animal Genes : TreeFamHTN3
HOVERGENP15516
HOGENOMP15516
Homologs : HomoloGeneHTN3
Homology/Alignments : Family Browser (UCSC)HTN3
Gene fusions - Rearrangements
Fusion : MitelmanDAB2IP/HTN3 [9q33.2/4q13.3]  [t(4;9)(q13;q33)]  
Fusion : MitelmanKCNE2/HTN3 [21q22.11/4q13.3]  [t(4;21)(q13;q22)]  
Fusion: TCGADAB2IP 9q33.2 HTN3 4q13.3 BRCA
Fusion: TCGAKCNE2 21q22.11 HTN3 4q13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHTN3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HTN3
dbVarHTN3
ClinVarHTN3
1000_GenomesHTN3 
Exome Variant ServerHTN3
ExAC (Exome Aggregation Consortium)HTN3 (select the gene name)
Genetic variants : HAPMAP3347
Genomic Variants (DGV)HTN3 [DGVbeta]
DECIPHER (Syndromes)4:70894130-70902255  ENSG00000205649
CONAN: Copy Number AnalysisHTN3 
Mutations
ICGC Data PortalHTN3 
TCGA Data PortalHTN3 
Broad Tumor PortalHTN3
OASIS PortalHTN3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHTN3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHTN3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HTN3
DgiDB (Drug Gene Interaction Database)HTN3
DoCM (Curated mutations)HTN3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HTN3 (select a term)
intoGenHTN3
Cancer3DHTN3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM142702   
Orphanet
MedgenHTN3
Genetic Testing Registry HTN3
NextProtP15516 [Medical]
TSGene3347
GENETestsHTN3
Huge Navigator HTN3 [HugePedia]
snp3D : Map Gene to Disease3347
BioCentury BCIQHTN3
ClinGenHTN3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3347
Chemical/Pharm GKB GenePA29547
Clinical trialHTN3
Miscellaneous
canSAR (ICR)HTN3 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHTN3
EVEXHTN3
GoPubMedHTN3
iHOPHTN3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:04:31 CEST 2017

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