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HTR1A (5-hydroxytryptamine receptor 1A)

Identity

Alias (NCBI)5-HT-1A
5-HT1A
5HT1a
ADRB2RL1
ADRBRL1
G-21
PFMCD
HGNC (Hugo) HTR1A
HGNC Alias symb5-HT1A
HGNC Previous nameADRB2RL1
 ADRBRL1
HGNC Previous name5-hydroxytryptamine (serotonin) receptor 1A
 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
LocusID (NCBI) 3350
Atlas_Id 52726
Location 5q12.3  [Link to chromosome band 5q12]
Location_base_pair Starts at 63957876 and ends at 63962445 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)HTR1A   5286
Cards
Entrez_Gene (NCBI)HTR1A    5-hydroxytryptamine receptor 1A
Aliases5-HT-1A; 5-HT1A; 5HT1a; ADRB2RL1; 
ADRBRL1; G-21; PFMCD
GeneCards (Weizmann)HTR1A
Ensembl hg19 (Hinxton)ENSG00000178394 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178394 [Gene_View]  ENSG00000178394 [Sequence]  chr5:63957876-63962445 [Contig_View]  HTR1A [Vega]
ICGC DataPortalENSG00000178394
TCGA cBioPortalHTR1A
AceView (NCBI)HTR1A
Genatlas (Paris)HTR1A
SOURCE (Princeton)HTR1A
Genetics Home Reference (NIH)HTR1A
Genomic and cartography
GoldenPath hg38 (UCSC)HTR1A  -     chr5:63957876-63962445 -  5q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HTR1A  -     5q12.3   [Description]    (hg19-Feb_2009)
GoldenPathHTR1A - 5q12.3 [CytoView hg19]  HTR1A - 5q12.3 [CytoView hg38]
ImmunoBaseENSG00000178394
Genome Data Viewer NCBIHTR1A [Mapview hg19]  
OMIM109760   614674   
Gene and transcription
Genbank (Entrez)AF498978 AK291429 AK314187 BC069159 BC136263
RefSeq transcript (Entrez)NM_000524
Consensus coding sequences : CCDS (NCBI)HTR1A
Gene ExpressionHTR1A [ NCBI-GEO ]   HTR1A [ EBI - ARRAY_EXPRESS ]   HTR1A [ SEEK ]   HTR1A [ MEM ]
Gene Expression Viewer (FireBrowse)HTR1A [ Firebrowse - Broad ]
GenevisibleExpression of HTR1A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3350
GTEX Portal (Tissue expression)HTR1A
Human Protein AtlasENSG00000178394-HTR1A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08908   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08908  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08908
PhosPhoSitePlusP08908
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)5HT1A_rcpt    5HT_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)HTR1A
SuperfamilyP08908
AlphaFold pdb e-kbP08908   
Human Protein Atlas [tissue]ENSG00000178394-HTR1A [tissue]
HPRD00190
Protein Interaction databases
DIP (DOE-UCLA)P08908
IntAct (EBI)P08908
BioGRIDHTR1A
STRING (EMBL)HTR1A
ZODIACHTR1A
Ontologies - Pathways
QuickGOP08908
Ontology : AmiGObehavioral fear response  G protein-coupled serotonin receptor activity  G protein-coupled serotonin receptor activity  G protein-coupled serotonin receptor activity  protein binding  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  adenylate cyclase-inhibiting serotonin receptor signaling pathway  adenylate cyclase-inhibiting serotonin receptor signaling pathway  serotonin receptor signaling pathway  gamma-aminobutyric acid signaling pathway  chemical synaptic transmission  positive regulation of cell population proliferation  regulation of serotonin secretion  regulation of vasoconstriction  dendrite  neurotransmitter receptor activity  exploration behavior  regulation of dopamine metabolic process  serotonin metabolic process  synapse  regulation of hormone secretion  regulation of behavior  serotonin binding  receptor-receptor interaction  
Ontology : EGO-EBIbehavioral fear response  G protein-coupled serotonin receptor activity  G protein-coupled serotonin receptor activity  G protein-coupled serotonin receptor activity  protein binding  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  adenylate cyclase-inhibiting serotonin receptor signaling pathway  adenylate cyclase-inhibiting serotonin receptor signaling pathway  serotonin receptor signaling pathway  gamma-aminobutyric acid signaling pathway  chemical synaptic transmission  positive regulation of cell population proliferation  regulation of serotonin secretion  regulation of vasoconstriction  dendrite  neurotransmitter receptor activity  exploration behavior  regulation of dopamine metabolic process  serotonin metabolic process  synapse  regulation of hormone secretion  regulation of behavior  serotonin binding  receptor-receptor interaction  
Pathways : KEGGNeuroactive ligand-receptor interaction    Serotonergic synapse   
NDEx NetworkHTR1A
Atlas of Cancer Signalling NetworkHTR1A
Wikipedia pathwaysHTR1A
Orthology - Evolution
OrthoDB3350
GeneTree (enSembl)ENSG00000178394
Phylogenetic Trees/Animal Genes : TreeFamHTR1A
Homologs : HomoloGeneHTR1A
Homology/Alignments : Family Browser (UCSC)HTR1A
Gene fusions - Rearrangements
Fusion : QuiverHTR1A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHTR1A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HTR1A
dbVarHTR1A
ClinVarHTR1A
MonarchHTR1A
1000_GenomesHTR1A 
Exome Variant ServerHTR1A
GNOMAD BrowserENSG00000178394
Varsome BrowserHTR1A
ACMGHTR1A variants
VarityP08908
Genomic Variants (DGV)HTR1A [DGVbeta]
DECIPHERHTR1A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHTR1A 
Mutations
ICGC Data PortalHTR1A 
TCGA Data PortalHTR1A 
Broad Tumor PortalHTR1A
OASIS PortalHTR1A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHTR1A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHTR1A
Mutations and Diseases : HGMDHTR1A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHTR1A
DgiDB (Drug Gene Interaction Database)HTR1A
DoCM (Curated mutations)HTR1A
CIViC (Clinical Interpretations of Variants in Cancer)HTR1A
Cancer3DHTR1A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM109760    614674   
Orphanet
DisGeNETHTR1A
MedgenHTR1A
Genetic Testing Registry HTR1A
NextProtP08908 [Medical]
GENETestsHTR1A
Target ValidationHTR1A
Huge Navigator HTR1A [HugePedia]
ClinGenHTR1A
Clinical trials, drugs, therapy
MyCancerGenomeHTR1A
Protein Interactions : CTDHTR1A
Pharm GKB GenePA192
Pharm GKB PathwaysPA161749006   
PharosP08908
Clinical trialHTR1A
Miscellaneous
canSAR (ICR)HTR1A
HarmonizomeHTR1A
DataMed IndexHTR1A
Probes
Litterature
PubMed370 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHTR1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:13:12 CEST 2021

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