Identity
HGNC
LOCATION
5q12.3
LOCUSID
ALIAS
5-HT-1A,5-HT1A,5HT1a,ADRB2RL1,ADRBRL1,G-21,PFMCD
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3350
MIM: 109760
HGNC: 5286
Ensembl: ENSG00000178394
Variants:
dbSNP: 3350
ClinVar: 3350
TCGA: ENSG00000178394
COSMIC: HTR1A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000178394 | ENST00000323865 | P08908 |
| ENSG00000178394 | ENST00000323865 | Q5ZGX3 |
| ENSG00000178394 | ENST00000506598 | D6RA34 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA162565877 | amisulpride | Chemical | ClinicalAnnotation | associated | PD | 22120873 | |
| PA164713257 | Selective serotonin reuptake inhibitors | Chemical | ClinicalAnnotation, Literature, MultilinkAnnotation | associated | PD | 18047755, 18387740, 18484082, 19590397, 19800133, 21688171, 23733030, 24930681 | |
| PA164752812 | milnacipran | Chemical | ClinicalAnnotation | associated | PD | 18484082 | |
| PA166129557 | lurasidone | Chemical | ClinicalAnnotation | associated | PD | 31636356 | |
| PA172 | GNAI1 | Gene | Pathway | associated | 19741567 | ||
| PA173 | GNAI3 | Gene | Pathway | associated | 19741567 | ||
| PA24347 | GNAI2 | Gene | Pathway | associated | 19741567 | ||
| PA446876 | Substance-Related Disorders | Disease | ClinicalAnnotation | associated | PD | 19747927 | |
| PA447207 | Depressive Disorder | Disease | ClinicalAnnotation | associated | PD | 18047755, 18387740, 18484082, 19590397, 19800133, 21688171, 23733030 | |
| PA447212 | Panic Disorder | Disease | ClinicalAnnotation | associated | PD | 19590397, 19800133, 21688171 | |
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | PD | 22120873, 25560469, 31636356 | |
| PA447321 | Depressive Disorder, Major | Disease | ClinicalAnnotation | associated | PD | 16302021, 18047755, 18387740, 18484082, 19590397, 19800133, 21688171, 23733030 | |
| PA449061 | clozapine | Chemical | ClinicalAnnotation | associated | PD | 25560469 | |
| PA449673 | fluoxetine | Chemical | ClinicalAnnotation | associated | PD | 16302021, 19590397 | |
| PA449690 | fluvoxamine | Chemical | ClinicalAnnotation | associated | PD | 18047755, 18387740, 18484082, 19590397, 19800133, 21688171, 23733030 | |
| PA450403 | methamphetamine | Chemical | ClinicalAnnotation | associated | PD | 19747927 | |
| PA450688 | olanzapine | Chemical | ClinicalAnnotation | associated | PD | 22120873 | |
| PA450801 | paroxetine | Chemical | ClinicalAnnotation | associated | PD | 18047755, 18387740, 18484082, 19590397, 19800133, 21688171, 23733030 | |
| PA451201 | quetiapine | Chemical | ClinicalAnnotation | associated | PD | 22120873 | |
| PA451257 | risperidone | Chemical | ClinicalAnnotation | associated | PD | 22120873 | |
| PA451333 | sertraline | Chemical | ClinicalAnnotation | associated | PD | 18047755, 18387740, 18484082, 19590397, 19800133, 21688171, 23733030 | |
| PA452229 | antidepressants | Chemical | ClinicalAnnotation | associated | PD | 18047755, 18387740, 18484082, 19590397, 19800133, 21688171, 23733030 | |
| PA452233 | antipsychotics | Chemical | ClinicalAnnotation | associated | PD | 22120873 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36214900 | 2023 | Association between the HTR1A rs6295 gene polymorphism and suicidal behavior: an updated meta-analysis. | 0 |
| 36533718 | 2023 | Metabolic depletion of sphingolipids inhibits agonist-induced endocytosis of the serotonin(1A) receptor. | 1 |
| 36691786 | 2023 | In vivo serotonin 1A receptor hippocampal binding potential in depression and reported childhood adversity. | 2 |
| 36769290 | 2023 | Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development. | 2 |
| 36980311 | 2023 | HTR1A, TPH2, and 5-HTTLPR Polymorphisms and Their Impact on the Severity of Depressive Symptoms and on the Concentration of Tryptophan Catabolites during Hepatitis C Treatment with Pegylated Interferon-α2a and Oral Ribavirin (PEG-IFN-α2a/RBV). | 0 |
| 37161455 | 2023 | Influence of TPH2 and HTR1A polymorphisms on lifelong premature ejaculation risk among the chinese Han population. | 0 |
| 37323077 | 2023 | Association between single-nucleotide polymorphisms in serotonin receptor 2A and melatonin receptor 1A genes and pain after root canal treatment. | 2 |
| 37473654 | 2023 | The association between 5-HT1A binding and temporal lobe epilepsy: A meta-analysis of molecular imaging studies. | 1 |
| 37525034 | 2023 | ADRA2B and HTR1A: An Updated Study of the Biogenic Amine Receptors Reveals Novel Conserved Motifs Which Play Key Role in Mental Disorders. | 2 |
| 37567783 | 2023 | Gα Protein Signaling Bias at Serotonin 1A Receptor. | 0 |
| 37958600 | 2023 | Transcriptional Regulation of the Human 5-HT1A Receptor Gene by Lithium: Role of Deaf1 and GSK3β. | 1 |
| 37984468 | 2023 | Genetic variation of the 5-HT1A rs6295, 5-HT2A rs6311, and CNR1 rs1049353 and an altered endocannabinoid system in depressed patients. | 1 |
| 36214900 | 2023 | Association between the HTR1A rs6295 gene polymorphism and suicidal behavior: an updated meta-analysis. | 0 |
| 36533718 | 2023 | Metabolic depletion of sphingolipids inhibits agonist-induced endocytosis of the serotonin(1A) receptor. | 1 |
| 36691786 | 2023 | In vivo serotonin 1A receptor hippocampal binding potential in depression and reported childhood adversity. | 2 |
Citation
Dessen P
HTR1A (5-hydroxytryptamine receptor 1A)
Atlas Genet Cytogenet Oncol Haematol. 2012-06-01
Online version: http://atlasgeneticsoncology.org/gene/52726/htr1a
