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HTR1A (5-hydroxytryptamine receptor 1A)

Identity

Alias_namesADRB2RL1
ADRBRL1
5-hydroxytryptamine (serotonin) receptor 1A
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
Alias_symbol (synonym)5-HT1A
Other alias5-HT-1A
5HT1a
G-21
PFMCD
HGNC (Hugo) HTR1A
LocusID (NCBI) 3350
Atlas_Id 52726
Location 5q12.3  [Link to chromosome band 5q12]
Location_base_pair Starts at 63255875 and ends at 63258119 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HTR1A   5286
Cards
Entrez_Gene (NCBI)HTR1A  3350  5-hydroxytryptamine receptor 1A
Aliases5-HT-1A; 5-HT1A; 5HT1a; ADRB2RL1; 
ADRBRL1; G-21; PFMCD
GeneCards (Weizmann)HTR1A
Ensembl hg19 (Hinxton)ENSG00000178394 [Gene_View]  chr5:63255875-63258119 [Contig_View]  HTR1A [Vega]
Ensembl hg38 (Hinxton)ENSG00000178394 [Gene_View]  chr5:63255875-63258119 [Contig_View]  HTR1A [Vega]
ICGC DataPortalENSG00000178394
TCGA cBioPortalHTR1A
AceView (NCBI)HTR1A
Genatlas (Paris)HTR1A
WikiGenes3350
SOURCE (Princeton)HTR1A
Genetics Home Reference (NIH)HTR1A
Genomic and cartography
GoldenPath hg19 (UCSC)HTR1A  -     chr5:63255875-63258119 -  5q12.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HTR1A  -     5q12.3   [Description]    (hg38-Dec_2013)
EnsemblHTR1A - 5q12.3 [CytoView hg19]  HTR1A - 5q12.3 [CytoView hg38]
Mapping of homologs : NCBIHTR1A [Mapview hg19]  HTR1A [Mapview hg38]
OMIM109760   614674   
Gene and transcription
Genbank (Entrez)AF498978 AK291429 AK314187 BC069159 BC136263
RefSeq transcript (Entrez)NM_000524
RefSeq genomic (Entrez)NC_000005 NC_018916 NG_032816 NT_034772 NW_004929322
Consensus coding sequences : CCDS (NCBI)HTR1A
Cluster EST : UnigeneHs.247940 [ NCBI ]
CGAP (NCI)Hs.247940
Alternative Splicing GalleryENSG00000178394
Gene ExpressionHTR1A [ NCBI-GEO ]   HTR1A [ EBI - ARRAY_EXPRESS ]   HTR1A [ SEEK ]   HTR1A [ MEM ]
Gene Expression Viewer (FireBrowse)HTR1A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3350
GTEX Portal (Tissue expression)HTR1A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08908   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08908  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08908
Splice isoforms : SwissVarP08908
PhosPhoSitePlusP08908
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)5HT1A_rcpt    5HT_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)HTR1A
DMDM Disease mutations3350
Blocks (Seattle)HTR1A
SuperfamilyP08908
Human Protein AtlasENSG00000178394
Peptide AtlasP08908
HPRD00190
IPIIPI00031686   IPI00978430   IPI00967501   
Protein Interaction databases
DIP (DOE-UCLA)P08908
IntAct (EBI)P08908
FunCoupENSG00000178394
BioGRIDHTR1A
STRING (EMBL)HTR1A
ZODIACHTR1A
Ontologies - Pathways
QuickGOP08908
Ontology : AmiGObehavioral fear response  G-protein coupled serotonin receptor activity  G-protein coupled serotonin receptor activity  protein binding  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting serotonin receptor signaling pathway  serotonin receptor signaling pathway  cell proliferation  positive regulation of cell proliferation  regulation of serotonin secretion  exploration behavior  regulation of dopamine metabolic process  vasoconstriction  serotonin metabolic process  regulation of hormone secretion  regulation of behavior  
Ontology : EGO-EBIbehavioral fear response  G-protein coupled serotonin receptor activity  G-protein coupled serotonin receptor activity  protein binding  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting serotonin receptor signaling pathway  serotonin receptor signaling pathway  cell proliferation  positive regulation of cell proliferation  regulation of serotonin secretion  exploration behavior  regulation of dopamine metabolic process  vasoconstriction  serotonin metabolic process  regulation of hormone secretion  regulation of behavior  
Pathways : KEGGNeuroactive ligand-receptor interaction    Serotonergic synapse   
NDEx NetworkHTR1A
Atlas of Cancer Signalling NetworkHTR1A
Wikipedia pathwaysHTR1A
Orthology - Evolution
OrthoDB3350
GeneTree (enSembl)ENSG00000178394
Phylogenetic Trees/Animal Genes : TreeFamHTR1A
HOVERGENP08908
HOGENOMP08908
Homologs : HomoloGeneHTR1A
Homology/Alignments : Family Browser (UCSC)HTR1A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHTR1A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HTR1A
dbVarHTR1A
ClinVarHTR1A
1000_GenomesHTR1A 
Exome Variant ServerHTR1A
ExAC (Exome Aggregation Consortium)HTR1A (select the gene name)
Genetic variants : HAPMAP3350
Genomic Variants (DGV)HTR1A [DGVbeta]
DECIPHER (Syndromes)5:63255875-63258119  ENSG00000178394
CONAN: Copy Number AnalysisHTR1A 
Mutations
ICGC Data PortalHTR1A 
TCGA Data PortalHTR1A 
Broad Tumor PortalHTR1A
OASIS PortalHTR1A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHTR1A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHTR1A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch HTR1A
DgiDB (Drug Gene Interaction Database)HTR1A
DoCM (Curated mutations)HTR1A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HTR1A (select a term)
intoGenHTR1A
Cancer3DHTR1A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM109760    614674   
Orphanet
MedgenHTR1A
Genetic Testing Registry HTR1A
NextProtP08908 [Medical]
TSGene3350
GENETestsHTR1A
Huge Navigator HTR1A [HugePedia]
snp3D : Map Gene to Disease3350
BioCentury BCIQHTR1A
ClinGenHTR1A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3350
Chemical/Pharm GKB GenePA192
Clinical trialHTR1A
Miscellaneous
canSAR (ICR)HTR1A (select the gene name)
Probes
Litterature
PubMed318 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHTR1A
EVEXHTR1A
GoPubMedHTR1A
iHOPHTR1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:09:58 CET 2017

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