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HTR1E (5-hydroxytryptamine receptor 1E)

Identity

Alias_names5-hydroxytryptamine (serotonin) receptor 1E
5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
Alias_symbol (synonym)5-HT1E
Other alias
HGNC (Hugo) HTR1E
LocusID (NCBI) 3354
Atlas_Id 54370
Location 6q14.3  [Link to chromosome band 6q14]
Location_base_pair Starts at 86937306 and ends at 87016679 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAM83B (6p12.1) / HTR1E (6q14.3)LRBA (4q31.3) / HTR1E (6q14.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Lung: Translocations in Squamous Cell Carcinoma
t(6;6)(p12;q14) FAM83B/HTR1E


External links

Nomenclature
HGNC (Hugo)HTR1E   5291
Cards
Entrez_Gene (NCBI)HTR1E  3354  5-hydroxytryptamine receptor 1E
Aliases5-HT1E
GeneCards (Weizmann)HTR1E
Ensembl hg19 (Hinxton)ENSG00000168830 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168830 [Gene_View]  ENSG00000168830 [Sequence]  chr6:86937306-87016679 [Contig_View]  HTR1E [Vega]
ICGC DataPortalENSG00000168830
TCGA cBioPortalHTR1E
AceView (NCBI)HTR1E
Genatlas (Paris)HTR1E
WikiGenes3354
SOURCE (Princeton)HTR1E
Genetics Home Reference (NIH)HTR1E
Genomic and cartography
GoldenPath hg38 (UCSC)HTR1E  -     chr6:86937306-87016679 +  6q14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HTR1E  -     6q14.3   [Description]    (hg19-Feb_2009)
EnsemblHTR1E - 6q14.3 [CytoView hg19]  HTR1E - 6q14.3 [CytoView hg38]
Mapping of homologs : NCBIHTR1E [Mapview hg19]  HTR1E [Mapview hg38]
OMIM182132   
Gene and transcription
Genbank (Entrez)AF498980 AL521170 BC069751 M91467
RefSeq transcript (Entrez)NM_000865
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HTR1E
Cluster EST : UnigeneHs.1611 [ NCBI ]
CGAP (NCI)Hs.1611
Alternative Splicing GalleryENSG00000168830
Gene ExpressionHTR1E [ NCBI-GEO ]   HTR1E [ EBI - ARRAY_EXPRESS ]   HTR1E [ SEEK ]   HTR1E [ MEM ]
Gene Expression Viewer (FireBrowse)HTR1E [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3354
GTEX Portal (Tissue expression)HTR1E
Human Protein AtlasENSG00000168830-HTR1E [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP28566   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP28566  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP28566
Splice isoforms : SwissVarP28566
PhosPhoSitePlusP28566
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)5HT1E_rcpt    5HT_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)HTR1E
DMDM Disease mutations3354
Blocks (Seattle)HTR1E
SuperfamilyP28566
Human Protein Atlas [tissue]ENSG00000168830-HTR1E [tissue]
Peptide AtlasP28566
HPRD01635
IPIIPI00003932   
Protein Interaction databases
DIP (DOE-UCLA)P28566
IntAct (EBI)P28566
FunCoupENSG00000168830
BioGRIDHTR1E
STRING (EMBL)HTR1E
ZODIACHTR1E
Ontologies - Pathways
QuickGOP28566
Ontology : AmiGOG protein-coupled receptor activity  G protein-coupled serotonin receptor activity  G protein-coupled serotonin receptor activity  G protein-coupled serotonin receptor activity  protein binding  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  chemical synaptic transmission  dendrite  neurotransmitter receptor activity  serotonin binding  G protein-coupled serotonin receptor signaling pathway  
Ontology : EGO-EBIG protein-coupled receptor activity  G protein-coupled serotonin receptor activity  G protein-coupled serotonin receptor activity  G protein-coupled serotonin receptor activity  protein binding  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  chemical synaptic transmission  dendrite  neurotransmitter receptor activity  serotonin binding  G protein-coupled serotonin receptor signaling pathway  
Pathways : KEGGNeuroactive ligand-receptor interaction    Serotonergic synapse   
NDEx NetworkHTR1E
Atlas of Cancer Signalling NetworkHTR1E
Wikipedia pathwaysHTR1E
Orthology - Evolution
OrthoDB3354
GeneTree (enSembl)ENSG00000168830
Phylogenetic Trees/Animal Genes : TreeFamHTR1E
HOVERGENP28566
HOGENOMP28566
Homologs : HomoloGeneHTR1E
Homology/Alignments : Family Browser (UCSC)HTR1E
Gene fusions - Rearrangements
Fusion : MitelmanFAM83B/HTR1E [6p12.1/6q14.3]  [t(6;6)(p12;q14)]  
Fusion : QuiverHTR1E
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHTR1E [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HTR1E
dbVarHTR1E
ClinVarHTR1E
1000_GenomesHTR1E 
Exome Variant ServerHTR1E
ExAC (Exome Aggregation Consortium)ENSG00000168830
GNOMAD BrowserENSG00000168830
Varsome BrowserHTR1E
Genetic variants : HAPMAP3354
Genomic Variants (DGV)HTR1E [DGVbeta]
DECIPHERHTR1E [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHTR1E 
Mutations
ICGC Data PortalHTR1E 
TCGA Data PortalHTR1E 
Broad Tumor PortalHTR1E
OASIS PortalHTR1E [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHTR1E  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHTR1E
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HTR1E
DgiDB (Drug Gene Interaction Database)HTR1E
DoCM (Curated mutations)HTR1E (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HTR1E (select a term)
intoGenHTR1E
Cancer3DHTR1E(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182132   
Orphanet
DisGeNETHTR1E
MedgenHTR1E
Genetic Testing Registry HTR1E
NextProtP28566 [Medical]
TSGene3354
GENETestsHTR1E
Target ValidationHTR1E
Huge Navigator HTR1E [HugePedia]
snp3D : Map Gene to Disease3354
BioCentury BCIQHTR1E
ClinGenHTR1E
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3354
Chemical/Pharm GKB GenePA29552
Clinical trialHTR1E
Miscellaneous
canSAR (ICR)HTR1E (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHTR1E
EVEXHTR1E
GoPubMedHTR1E
iHOPHTR1E
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:12:20 CET 2018

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