HTR1F (5-hydroxytryptamine receptor 1F)

2014-11-01  

Identity

HGNC
LOCATION
3p11.2
LOCUSID
ALIAS
5-HT-1F,5-HT1F,5HT6,HTR1EL,MR77

Other Information

Locus ID:

NCBI: 3355
MIM: 182134
HGNC: 5292
Ensembl: ENSG00000179097

Variants:

dbSNP: 3355
ClinVar: 3355
TCGA: ENSG00000179097
COSMIC: HTR1F

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179097ENST00000319595P30939

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Taste transductionKEGGko04742
Neuroactive ligand-receptor interactionKEGGhsa04080
Taste transductionKEGGhsa04742
Serotonergic synapseKEGGhsa04726
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Serotonin receptorsREACTOMER-HSA-390666
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA172GNAI1GenePathwayassociated19741567
PA173GNAI3GenePathwayassociated19741567
PA24347GNAI2GenePathwayassociated19741567

References

Pubmed IDYearTitleCitations
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
280092962016Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells.23
194556002010Association study of the serotoninergic system in migraine in the Spanish population.11
126274642003Suicide and serotonin: study of variation at seven serotonin receptor genes in suicide completers.9
168561202006Association study of seven polymorphisms in four serotonin receptor genes on suicide victims.2
214570692011Association analysis of TPH2, 5-HT2A, and 5-HT6 with executive function in a young Chinese Han population.1

Citation

Dessen P

HTR1F (5-hydroxytryptamine receptor 1F)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64465/htr1f