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HTR2A (5-hydroxytryptamine receptor 2A)

Identity

Alias_namesHTR2
5-hydroxytryptamine (serotonin) receptor 2A
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
Alias_symbol (synonym)5-HT2A
Other alias
HGNC (Hugo) HTR2A
LocusID (NCBI) 3356
Atlas_Id 46384
Location 13q14.2  [Link to chromosome band 13q14]
Location_base_pair Starts at 46831542 and ends at 46897076 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MED4 (13q14.2) / HTR2A (13q14.2)MED4 13q14.2 / HTR2A 13q14.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HTR2A   5293
LRG (Locus Reference Genomic)LRG_1008
Cards
Entrez_Gene (NCBI)HTR2A  3356  5-hydroxytryptamine receptor 2A
Aliases5-HT2A; HTR2
GeneCards (Weizmann)HTR2A
Ensembl hg19 (Hinxton)ENSG00000102468 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000102468 [Gene_View]  chr13:46831542-46897076 [Contig_View]  HTR2A [Vega]
ICGC DataPortalENSG00000102468
TCGA cBioPortalHTR2A
AceView (NCBI)HTR2A
Genatlas (Paris)HTR2A
WikiGenes3356
SOURCE (Princeton)HTR2A
Genetics Home Reference (NIH)HTR2A
Genomic and cartography
GoldenPath hg38 (UCSC)HTR2A  -     chr13:46831542-46897076 -  13q14.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HTR2A  -     13q14.2   [Description]    (hg19-Feb_2009)
EnsemblHTR2A - 13q14.2 [CytoView hg19]  HTR2A - 13q14.2 [CytoView hg38]
Mapping of homologs : NCBIHTR2A [Mapview hg19]  HTR2A [Mapview hg38]
OMIM103780   164230   181500   182135   606788   608516   
Gene and transcription
Genbank (Entrez)A23337 AA418604 AF498982 AK302787 AK314132
RefSeq transcript (Entrez)NM_000621 NM_001165947
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HTR2A
Cluster EST : UnigeneHs.72630 [ NCBI ]
CGAP (NCI)Hs.72630
Alternative Splicing GalleryENSG00000102468
Gene ExpressionHTR2A [ NCBI-GEO ]   HTR2A [ EBI - ARRAY_EXPRESS ]   HTR2A [ SEEK ]   HTR2A [ MEM ]
Gene Expression Viewer (FireBrowse)HTR2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3356
GTEX Portal (Tissue expression)HTR2A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP28223   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP28223  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP28223
Splice isoforms : SwissVarP28223
PhosPhoSitePlusP28223
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)5HT2A_rcpt    5HT_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)HTR2A
DMDM Disease mutations3356
Blocks (Seattle)HTR2A
SuperfamilyP28223
Human Protein AtlasENSG00000102468
Peptide AtlasP28223
HPRD01638
IPIIPI00002185   IPI00942926   
Protein Interaction databases
DIP (DOE-UCLA)P28223
IntAct (EBI)P28223
FunCoupENSG00000102468
BioGRIDHTR2A
STRING (EMBL)HTR2A
ZODIACHTR2A
Ontologies - Pathways
QuickGOP28223
Ontology : AmiGOvirus receptor activity  temperature homeostasis  G-protein alpha-subunit binding  G-protein coupled serotonin receptor activity  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  caveola  cellular calcium ion homeostasis  phospholipase C-activating G-protein coupled receptor signaling pathway  activation of phospholipase C activity  phospholipase C-activating serotonin receptor signaling pathway  serotonin receptor signaling pathway  chemical synaptic transmission  aging  memory  drug binding  cell death  positive regulation of cell proliferation  positive regulation of phosphatidylinositol biosynthetic process  regulation of dopamine secretion  phosphatidylinositol 3-kinase signaling  artery smooth muscle contraction  urinary bladder smooth muscle contraction  axon  sleep  neurotransmitter receptor activity  cytoplasmic vesicle  protein complex binding  response to drug  neuronal cell body  dendritic shaft  negative regulation of potassium ion transport  positive regulation of MAP kinase activity  protein localization to cytoskeleton  positive regulation of fat cell differentiation  positive regulation of glycolytic process  positive regulation of vasoconstriction  viral entry into host cell  regulation of hormone secretion  behavioral response to cocaine  positive regulation of peptidyl-tyrosine phosphorylation  regulation of behavior  detection of temperature stimulus involved in sensory perception of pain  detection of mechanical stimulus involved in sensory perception of pain  release of sequestered calcium ion into cytosol  release of sequestered calcium ion into cytosol  serotonin binding  negative regulation of synaptic transmission, glutamatergic  positive regulation of ERK1 and ERK2 cascade  cell body fiber  1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding  
Ontology : EGO-EBIvirus receptor activity  temperature homeostasis  G-protein alpha-subunit binding  G-protein coupled serotonin receptor activity  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  caveola  cellular calcium ion homeostasis  phospholipase C-activating G-protein coupled receptor signaling pathway  activation of phospholipase C activity  phospholipase C-activating serotonin receptor signaling pathway  serotonin receptor signaling pathway  chemical synaptic transmission  aging  memory  drug binding  cell death  positive regulation of cell proliferation  positive regulation of phosphatidylinositol biosynthetic process  regulation of dopamine secretion  phosphatidylinositol 3-kinase signaling  artery smooth muscle contraction  urinary bladder smooth muscle contraction  axon  sleep  neurotransmitter receptor activity  cytoplasmic vesicle  protein complex binding  response to drug  neuronal cell body  dendritic shaft  negative regulation of potassium ion transport  positive regulation of MAP kinase activity  protein localization to cytoskeleton  positive regulation of fat cell differentiation  positive regulation of glycolytic process  positive regulation of vasoconstriction  viral entry into host cell  regulation of hormone secretion  behavioral response to cocaine  positive regulation of peptidyl-tyrosine phosphorylation  regulation of behavior  detection of temperature stimulus involved in sensory perception of pain  detection of mechanical stimulus involved in sensory perception of pain  release of sequestered calcium ion into cytosol  release of sequestered calcium ion into cytosol  serotonin binding  negative regulation of synaptic transmission, glutamatergic  positive regulation of ERK1 and ERK2 cascade  cell body fiber  1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding  
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction    Gap junction    Serotonergic synapse   
NDEx NetworkHTR2A
Atlas of Cancer Signalling NetworkHTR2A
Wikipedia pathwaysHTR2A
Orthology - Evolution
OrthoDB3356
GeneTree (enSembl)ENSG00000102468
Phylogenetic Trees/Animal Genes : TreeFamHTR2A
HOVERGENP28223
HOGENOMP28223
Homologs : HomoloGeneHTR2A
Homology/Alignments : Family Browser (UCSC)HTR2A
Gene fusions - Rearrangements
Fusion : MitelmanMED4/HTR2A [13q14.2/13q14.2]  [t(13;13)(q14;q14)]  
Fusion: TCGAMED4 13q14.2 HTR2A 13q14.2 GBM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHTR2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HTR2A
dbVarHTR2A
ClinVarHTR2A
1000_GenomesHTR2A 
Exome Variant ServerHTR2A
ExAC (Exome Aggregation Consortium)HTR2A (select the gene name)
Genetic variants : HAPMAP3356
Genomic Variants (DGV)HTR2A [DGVbeta]
DECIPHERHTR2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHTR2A 
Mutations
ICGC Data PortalHTR2A 
TCGA Data PortalHTR2A 
Broad Tumor PortalHTR2A
OASIS PortalHTR2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHTR2A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHTR2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HTR2A
DgiDB (Drug Gene Interaction Database)HTR2A
DoCM (Curated mutations)HTR2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HTR2A (select a term)
intoGenHTR2A
Cancer3DHTR2A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM103780    164230    181500    182135    606788    608516   
Orphanet
MedgenHTR2A
Genetic Testing Registry HTR2A
NextProtP28223 [Medical]
TSGene3356
GENETestsHTR2A
Target ValidationHTR2A
Huge Navigator HTR2A [HugePedia]
snp3D : Map Gene to Disease3356
BioCentury BCIQHTR2A
ClinGenHTR2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3356
Chemical/Pharm GKB GenePA193
Clinical trialHTR2A
Miscellaneous
canSAR (ICR)HTR2A (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHTR2A
EVEXHTR2A
GoPubMedHTR2A
iHOPHTR2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:03:33 CEST 2017

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