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HTR2B (5-hydroxytryptamine receptor 2B)

Identity

Alias_names5-hydroxytryptamine (serotonin) receptor 2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
Alias_symbol (synonym)5-HT(2B)
5-HT2B
Other alias5-HT-2B
HGNC (Hugo) HTR2B
LocusID (NCBI) 3357
Atlas_Id 51585
Location 2q37.1  [Link to chromosome band 2q37]
Location_base_pair Starts at 231972950 and ends at 231989824 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
XRCC5 (2q35) / HTR2B (2q37.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HTR2B   5294
Cards
Entrez_Gene (NCBI)HTR2B  3357  5-hydroxytryptamine receptor 2B
Aliases5-HT(2B); 5-HT-2B; 5-HT2B
GeneCards (Weizmann)HTR2B
Ensembl hg19 (Hinxton)ENSG00000135914 [Gene_View]  chr2:231972950-231989824 [Contig_View]  HTR2B [Vega]
Ensembl hg38 (Hinxton)ENSG00000135914 [Gene_View]  chr2:231972950-231989824 [Contig_View]  HTR2B [Vega]
ICGC DataPortalENSG00000135914
TCGA cBioPortalHTR2B
AceView (NCBI)HTR2B
Genatlas (Paris)HTR2B
WikiGenes3357
SOURCE (Princeton)HTR2B
Genetics Home Reference (NIH)HTR2B
Genomic and cartography
GoldenPath hg19 (UCSC)HTR2B  -     chr2:231972950-231989824 -  2q37.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HTR2B  -     2q37.1   [Description]    (hg38-Dec_2013)
EnsemblHTR2B - 2q37.1 [CytoView hg19]  HTR2B - 2q37.1 [CytoView hg38]
Mapping of homologs : NCBIHTR2B [Mapview hg19]  HTR2B [Mapview hg38]
OMIM601122   
Gene and transcription
Genbank (Entrez)AK313741 AY114103 AY136751 BC063123 X77307
RefSeq transcript (Entrez)NM_000867 NM_001320758
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)HTR2B
Cluster EST : UnigeneHs.421649 [ NCBI ]
CGAP (NCI)Hs.421649
Alternative Splicing GalleryENSG00000135914
Gene ExpressionHTR2B [ NCBI-GEO ]   HTR2B [ EBI - ARRAY_EXPRESS ]   HTR2B [ SEEK ]   HTR2B [ MEM ]
Gene Expression Viewer (FireBrowse)HTR2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3357
GTEX Portal (Tissue expression)HTR2B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41595   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP41595  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41595
Splice isoforms : SwissVarP41595
PhosPhoSitePlusP41595
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)5HT2B_rcpt    5HT_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)HTR2B
DMDM Disease mutations3357
Blocks (Seattle)HTR2B
PDB (SRS)4IB4    4NC3   
PDB (PDBSum)4IB4    4NC3   
PDB (IMB)4IB4    4NC3   
PDB (RSDB)4IB4    4NC3   
Structural Biology KnowledgeBase4IB4    4NC3   
SCOP (Structural Classification of Proteins)4IB4    4NC3   
CATH (Classification of proteins structures)4IB4    4NC3   
SuperfamilyP41595
Human Protein AtlasENSG00000135914
Peptide AtlasP41595
HPRD03077
IPIIPI00015134   IPI01015111   
Protein Interaction databases
DIP (DOE-UCLA)P41595
IntAct (EBI)P41595
FunCoupENSG00000135914
BioGRIDHTR2B
STRING (EMBL)HTR2B
ZODIACHTR2B
Ontologies - Pathways
QuickGOP41595
Ontology : AmiGOneural crest cell migration  positive regulation of cytokine production  positive regulation of endothelial cell proliferation  G-protein alpha-subunit binding  G-protein coupled receptor internalization  heart morphogenesis  cardiac muscle hypertrophy  G-protein coupled serotonin receptor activity  GTPase activator activity  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  cGMP biosynthetic process  cellular calcium ion homeostasis  G-protein coupled receptor signaling pathway  activation of phospholipase C activity  protein kinase C-activating G-protein coupled receptor signaling pathway  serotonin receptor signaling pathway  behavior  drug binding  positive regulation of cell proliferation  positive regulation of cell proliferation  negative regulation of autophagy  positive regulation of phosphatidylinositol biosynthetic process  neural crest cell differentiation  phosphatidylinositol 3-kinase signaling  intestine smooth muscle contraction  phosphorylation  calcium-mediated signaling  cell junction  dendrite  hepatic stellate cell activation  vasoconstriction  response to drug  neuronal cell body  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of MAP kinase activity  positive regulation of GTPase activity  inositol phosphate metabolic process  synapse  embryonic morphogenesis  positive regulation of cytokine secretion  regulation of behavior  positive regulation of nitric-oxide synthase activity  release of sequestered calcium ion into cytosol  release of sequestered calcium ion into cytosol  serotonin binding  positive regulation of cell division  negative regulation of cell death  ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  protein kinase C signaling  cellular response to amine stimulus  cellular response to temperature stimulus  cellular response to serotonin  
Ontology : EGO-EBIneural crest cell migration  positive regulation of cytokine production  positive regulation of endothelial cell proliferation  G-protein alpha-subunit binding  G-protein coupled receptor internalization  heart morphogenesis  cardiac muscle hypertrophy  G-protein coupled serotonin receptor activity  GTPase activator activity  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  cGMP biosynthetic process  cellular calcium ion homeostasis  G-protein coupled receptor signaling pathway  activation of phospholipase C activity  protein kinase C-activating G-protein coupled receptor signaling pathway  serotonin receptor signaling pathway  behavior  drug binding  positive regulation of cell proliferation  positive regulation of cell proliferation  negative regulation of autophagy  positive regulation of phosphatidylinositol biosynthetic process  neural crest cell differentiation  phosphatidylinositol 3-kinase signaling  intestine smooth muscle contraction  phosphorylation  calcium-mediated signaling  cell junction  dendrite  hepatic stellate cell activation  vasoconstriction  response to drug  neuronal cell body  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of MAP kinase activity  positive regulation of GTPase activity  inositol phosphate metabolic process  synapse  embryonic morphogenesis  positive regulation of cytokine secretion  regulation of behavior  positive regulation of nitric-oxide synthase activity  release of sequestered calcium ion into cytosol  release of sequestered calcium ion into cytosol  serotonin binding  positive regulation of cell division  negative regulation of cell death  ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  protein kinase C signaling  cellular response to amine stimulus  cellular response to temperature stimulus  cellular response to serotonin  
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction    Gap junction    Serotonergic synapse   
NDEx NetworkHTR2B
Atlas of Cancer Signalling NetworkHTR2B
Wikipedia pathwaysHTR2B
Orthology - Evolution
OrthoDB3357
GeneTree (enSembl)ENSG00000135914
Phylogenetic Trees/Animal Genes : TreeFamHTR2B
HOVERGENP41595
HOGENOMP41595
Homologs : HomoloGeneHTR2B
Homology/Alignments : Family Browser (UCSC)HTR2B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHTR2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HTR2B
dbVarHTR2B
ClinVarHTR2B
1000_GenomesHTR2B 
Exome Variant ServerHTR2B
ExAC (Exome Aggregation Consortium)HTR2B (select the gene name)
Genetic variants : HAPMAP3357
Genomic Variants (DGV)HTR2B [DGVbeta]
DECIPHER (Syndromes)2:231972950-231989824  ENSG00000135914
CONAN: Copy Number AnalysisHTR2B 
Mutations
ICGC Data PortalHTR2B 
TCGA Data PortalHTR2B 
Broad Tumor PortalHTR2B
OASIS PortalHTR2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHTR2B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHTR2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HTR2B
DgiDB (Drug Gene Interaction Database)HTR2B
DoCM (Curated mutations)HTR2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HTR2B (select a term)
intoGenHTR2B
Cancer3DHTR2B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601122   
Orphanet
MedgenHTR2B
Genetic Testing Registry HTR2B
NextProtP41595 [Medical]
TSGene3357
GENETestsHTR2B
Huge Navigator HTR2B [HugePedia]
snp3D : Map Gene to Disease3357
BioCentury BCIQHTR2B
ClinGenHTR2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3357
Chemical/Pharm GKB GenePA29554
Clinical trialHTR2B
Miscellaneous
canSAR (ICR)HTR2B (select the gene name)
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHTR2B
EVEXHTR2B
GoPubMedHTR2B
iHOPHTR2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:04:32 CEST 2017

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