Atlas of Genetics and Cytogenetics in Oncology and Haematology

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HTR2C (5-hydroxytryptamine receptor 2C)

Identity

Alias_namesHTR1C
5-hydroxytryptamine (serotonin) receptor 2C
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
Alias_symbol (synonym)5-HT2C
5HTR2C
Other alias5-HT1C
5-HTR2C
HGNC (Hugo) HTR2C
LocusID (NCBI) 3358
Atlas_Id 55615
Location Xq23  [Link to chromosome band Xq23]
Location_base_pair Starts at 114584078 and ends at 114910061 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)HTR2C   5295
LRG (Locus Reference Genomic)LRG_1009
Cards
Entrez_Gene (NCBI)HTR2C  3358  5-hydroxytryptamine receptor 2C
Aliases5-HT1C; 5-HT2C; 5-HTR2C; 5HTR2C; 
HTR1C
GeneCards (Weizmann)HTR2C
Ensembl hg19 (Hinxton)ENSG00000147246 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000147246 [Gene_View]  ENSG00000147246 [Sequence]  chrX:114584078-114910061 [Contig_View]  HTR2C [Vega]
ICGC DataPortalENSG00000147246
TCGA cBioPortalHTR2C
AceView (NCBI)HTR2C
Genatlas (Paris)HTR2C
WikiGenes3358
SOURCE (Princeton)HTR2C
Genetics Home Reference (NIH)HTR2C
Genomic and cartography
GoldenPath hg38 (UCSC)HTR2C  -     chrX:114584078-114910061 +  Xq23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HTR2C  -     Xq23   [Description]    (hg19-Feb_2009)
HTR2C - Xq23 [CytoView hg19]  HTR2C - Xq23 [CytoView hg38]
Mapping of homologs : NCBIHTR2C [Mapview hg19]  HTR2C [Mapview hg38]
OMIM312861   
Gene and transcription
Genbank (Entrez)AF208053 AF498983 AK295753 AK308766 AY114104
RefSeq transcript (Entrez)NM_000868 NM_001256760 NM_001256761
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HTR2C
Cluster EST : UnigeneHs.149037 [ NCBI ]
CGAP (NCI)Hs.149037
Alternative Splicing GalleryENSG00000147246
Gene ExpressionHTR2C [ NCBI-GEO ]   HTR2C [ EBI - ARRAY_EXPRESS ]   HTR2C [ SEEK ]   HTR2C [ MEM ]
Gene Expression Viewer (FireBrowse)HTR2C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3358
GTEX Portal (Tissue expression)HTR2C
Human Protein AtlasENSG00000147246-HTR2C [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP28335   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP28335  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP28335
Splice isoforms : SwissVarP28335
PhosPhoSitePlusP28335
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)5HT2C_rcpt    5HT_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)HTR2C
DMDM Disease mutations3358
Blocks (Seattle)HTR2C
PDB (RSDB)6BQG    6BQH   
PDB Europe6BQG    6BQH   
PDB (PDBSum)6BQG    6BQH   
PDB (IMB)6BQG    6BQH   
Structural Biology KnowledgeBase6BQG    6BQH   
SCOP (Structural Classification of Proteins)6BQG    6BQH   
CATH (Classification of proteins structures)6BQG    6BQH   
SuperfamilyP28335
Human Protein Atlas [tissue]ENSG00000147246-HTR2C [tissue]
Peptide AtlasP28335
HPRD02429
IPIIPI00002876   IPI00477160   
Protein Interaction databases
DIP (DOE-UCLA)P28335
IntAct (EBI)P28335
FunCoupENSG00000147246
BioGRIDHTR2C
STRING (EMBL)HTR2C
ZODIACHTR2C
Ontologies - Pathways
QuickGOP28335
Ontology : AmiGOGq/11-coupled serotonin receptor activity  behavioral fear response  G protein-coupled receptor activity  G protein-coupled serotonin receptor activity  G protein-coupled serotonin receptor activity  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  cellular calcium ion homeostasis  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  phospholipase C-activating G protein-coupled receptor signaling pathway  phospholipase C-activating G protein-coupled receptor signaling pathway  phospholipase C-activating serotonin receptor signaling pathway  serotonin receptor signaling pathway  chemical synaptic transmission  locomotory behavior  feeding behavior  drug binding  positive regulation of phosphatidylinositol biosynthetic process  cGMP-mediated signaling  dendrite  neurotransmitter receptor activity  regulation of neurological system process  regulation of appetite  response to drug  response to drug  regulation of corticotropin-releasing hormone secretion  positive regulation of fat cell differentiation  release of sequestered calcium ion into cytosol  release of sequestered calcium ion into cytosol  serotonin binding  positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  positive regulation of ERK1 and ERK2 cascade  1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding  
Ontology : EGO-EBIGq/11-coupled serotonin receptor activity  behavioral fear response  G protein-coupled receptor activity  G protein-coupled serotonin receptor activity  G protein-coupled serotonin receptor activity  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  cellular calcium ion homeostasis  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  phospholipase C-activating G protein-coupled receptor signaling pathway  phospholipase C-activating G protein-coupled receptor signaling pathway  phospholipase C-activating serotonin receptor signaling pathway  serotonin receptor signaling pathway  chemical synaptic transmission  locomotory behavior  feeding behavior  drug binding  positive regulation of phosphatidylinositol biosynthetic process  cGMP-mediated signaling  dendrite  neurotransmitter receptor activity  regulation of neurological system process  regulation of appetite  response to drug  response to drug  regulation of corticotropin-releasing hormone secretion  positive regulation of fat cell differentiation  release of sequestered calcium ion into cytosol  release of sequestered calcium ion into cytosol  serotonin binding  positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  positive regulation of ERK1 and ERK2 cascade  1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding  
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction    Gap junction    Serotonergic synapse   
NDEx NetworkHTR2C
Atlas of Cancer Signalling NetworkHTR2C
Wikipedia pathwaysHTR2C
Orthology - Evolution
OrthoDB3358
GeneTree (enSembl)ENSG00000147246
Phylogenetic Trees/Animal Genes : TreeFamHTR2C
HOGENOMP28335
Homologs : HomoloGeneHTR2C
Homology/Alignments : Family Browser (UCSC)HTR2C
Gene fusions - Rearrangements
Fusion : QuiverHTR2C
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHTR2C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HTR2C
dbVarHTR2C
ClinVarHTR2C
1000_GenomesHTR2C 
Exome Variant ServerHTR2C
ExAC (Exome Aggregation Consortium)ENSG00000147246
GNOMAD BrowserENSG00000147246
Varsome BrowserHTR2C
Genetic variants : HAPMAP3358
Genomic Variants (DGV)HTR2C [DGVbeta]
DECIPHERHTR2C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHTR2C 
Mutations
ICGC Data PortalHTR2C 
TCGA Data PortalHTR2C 
Broad Tumor PortalHTR2C
OASIS PortalHTR2C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHTR2C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHTR2C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch HTR2C
DgiDB (Drug Gene Interaction Database)HTR2C
DoCM (Curated mutations)HTR2C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HTR2C (select a term)
intoGenHTR2C
Cancer3DHTR2C(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM312861   
Orphanet
DisGeNETHTR2C
MedgenHTR2C
Genetic Testing Registry HTR2C
NextProtP28335 [Medical]
TSGene3358
GENETestsHTR2C
Target ValidationHTR2C
Huge Navigator HTR2C [HugePedia]
snp3D : Map Gene to Disease3358
BioCentury BCIQHTR2C
ClinGenHTR2C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3358
Chemical/Pharm GKB GenePA194
Clinical trialHTR2C
Miscellaneous
canSAR (ICR)HTR2C (select the gene name)
DataMed IndexHTR2C
Probes
Litterature
PubMed271 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHTR2C
EVEXHTR2C
GoPubMedHTR2C
iHOPHTR2C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 21 15:50:23 CET 2019
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