Atlas of Genetics and Cytogenetics in Oncology and Haematology

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HTR3A (5-hydroxytryptamine receptor 3A)

Identity

Alias (NCBI)5-HT-3
5-HT3A
5-HT3R
5HT3R
HTR3
HGNC (Hugo) HTR3A
HGNC Alias symb5-HT3R
5-HT3A
HGNC Previous nameHTR3
HGNC Previous name5-hydroxytryptamine (serotonin) receptor 3A
 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
LocusID (NCBI) 3359
Atlas_Id 45674
Location 11q23.2  [Link to chromosome band 11q23]
Location_base_pair Starts at 113975108 and ends at 113990312 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)HTR3A   5297
Cards
Entrez_Gene (NCBI)HTR3A    5-hydroxytryptamine receptor 3A
Aliases5-HT-3; 5-HT3A; 5-HT3R; 5HT3R; 
HTR3
GeneCards (Weizmann)HTR3A
Ensembl hg19 (Hinxton)ENSG00000166736 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166736 [Gene_View]  ENSG00000166736 [Sequence]  chr11:113975108-113990312 [Contig_View]  HTR3A [Vega]
ICGC DataPortalENSG00000166736
TCGA cBioPortalHTR3A
AceView (NCBI)HTR3A
Genatlas (Paris)HTR3A
SOURCE (Princeton)HTR3A
Genetics Home Reference (NIH)HTR3A
Genomic and cartography
GoldenPath hg38 (UCSC)HTR3A  -     chr11:113975108-113990312 +  11q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HTR3A  -     11q23.2   [Description]    (hg19-Feb_2009)
GoldenPathHTR3A - 11q23.2 [CytoView hg19]  HTR3A - 11q23.2 [CytoView hg38]
ImmunoBaseENSG00000166736
genome Data Viewer NCBIHTR3A [Mapview hg19]  
OMIM182139   
Gene and transcription
Genbank (Entrez)AF498984 AJ003078 AJ003079 AJ003080 AJ003080
RefSeq transcript (Entrez)NM_000869 NM_001161772 NM_213621
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HTR3A
Alternative Splicing GalleryENSG00000166736
Gene ExpressionHTR3A [ NCBI-GEO ]   HTR3A [ EBI - ARRAY_EXPRESS ]   HTR3A [ SEEK ]   HTR3A [ MEM ]
Gene Expression Viewer (FireBrowse)HTR3A [ Firebrowse - Broad ]
GenevisibleExpression of HTR3A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3359
GTEX Portal (Tissue expression)HTR3A
Human Protein AtlasENSG00000166736-HTR3A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46098   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP46098  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP46098
Splice isoforms : SwissVarP46098
PhosPhoSitePlusP46098
Domaine pattern : Prosite (Expaxy)NEUROTR_ION_CHANNEL (PS00236)   
Domains : Interpro (EBI)5HT3_rcpt    5HT3_rcpt_A    Neur_chan_lig-bd    Neur_chan_lig-bd_sf    Neur_channel    Neuro-gated_channel_TM_sf    Neurotrans-gated_channel_TM    Neurotransmitter_ion_chnl_CS   
Domain families : Pfam (Sanger)Neur_chan_LBD (PF02931)    Neur_chan_memb (PF02932)   
Domain families : Pfam (NCBI)pfam02931    pfam02932   
Conserved Domain (NCBI)HTR3A
Blocks (Seattle)HTR3A
SuperfamilyP46098
Human Protein Atlas [tissue]ENSG00000166736-HTR3A [tissue]
Peptide AtlasP46098
HPRD08917
IPIIPI00748737   IPI00179555   IPI00963953   IPI00465351   IPI00967831   IPI01014761   
Protein Interaction databases
DIP (DOE-UCLA)P46098
IntAct (EBI)P46098
BioGRIDHTR3A
STRING (EMBL)HTR3A
ZODIACHTR3A
Ontologies - Pathways
QuickGOP46098
Ontology : AmiGOtransmembrane signaling receptor activity  protein binding  cytoplasm  plasma membrane  integral component of plasma membrane  signal transduction  serotonin receptor signaling pathway  chemical synaptic transmission  chemical synaptic transmission  serotonin-gated cation-selective channel activity  serotonin-gated cation-selective channel activity  axon  neurotransmitter receptor activity  cleavage furrow  positive regulation of ion transmembrane transporter activity  ion transmembrane transport  response to cocaine  regulation of membrane potential  neuron projection  neuronal cell body  synapse  response to ethanol  nervous system process  serotonin binding  cellular response to growth factor stimulus  glutamatergic synapse  integral component of postsynaptic membrane  integral component of presynaptic membrane  serotonin-activated cation-selective channel complex  
Ontology : EGO-EBItransmembrane signaling receptor activity  protein binding  cytoplasm  plasma membrane  integral component of plasma membrane  signal transduction  serotonin receptor signaling pathway  chemical synaptic transmission  chemical synaptic transmission  serotonin-gated cation-selective channel activity  serotonin-gated cation-selective channel activity  axon  neurotransmitter receptor activity  cleavage furrow  positive regulation of ion transmembrane transporter activity  ion transmembrane transport  response to cocaine  regulation of membrane potential  neuron projection  neuronal cell body  synapse  response to ethanol  nervous system process  serotonin binding  cellular response to growth factor stimulus  glutamatergic synapse  integral component of postsynaptic membrane  integral component of presynaptic membrane  serotonin-activated cation-selective channel complex  
Pathways : KEGGSerotonergic synapse   
NDEx NetworkHTR3A
Atlas of Cancer Signalling NetworkHTR3A
Wikipedia pathwaysHTR3A
Orthology - Evolution
OrthoDB3359
GeneTree (enSembl)ENSG00000166736
Phylogenetic Trees/Animal Genes : TreeFamHTR3A
HOGENOMP46098
Homologs : HomoloGeneHTR3A
Homology/Alignments : Family Browser (UCSC)HTR3A
Gene fusions - Rearrangements
Fusion : QuiverHTR3A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHTR3A [hg38]
dbVarHTR3A
ClinVarHTR3A
MonarchHTR3A
1000_GenomesHTR3A 
Exome Variant ServerHTR3A
GNOMAD BrowserENSG00000166736
Varsome BrowserHTR3A
Genomic Variants (DGV)HTR3A [DGVbeta]
DECIPHERHTR3A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHTR3A 
Mutations
ICGC Data PortalHTR3A 
TCGA Data PortalHTR3A 
Broad Tumor PortalHTR3A
OASIS PortalHTR3A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHTR3A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHTR3A
Mutations and Diseases : HGMDHTR3A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HTR3A
DgiDB (Drug Gene Interaction Database)HTR3A
DoCM (Curated mutations)HTR3A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HTR3A (select a term)
intoGenHTR3A
Cancer3DHTR3A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182139   
Orphanet
DisGeNETHTR3A
MedgenHTR3A
Genetic Testing Registry HTR3A
NextProtP46098 [Medical]
GENETestsHTR3A
Target ValidationHTR3A
Huge Navigator HTR3A [HugePedia]
ClinGenHTR3A
Clinical trials, drugs, therapy
MyCancerGenomeHTR3A
Protein Interactions : CTD
Pharm GKB GenePA29555
Pharm GKB PathwaysPA161749006   
PharosP46098
Clinical trialHTR3A
Miscellaneous
canSAR (ICR)HTR3A (select the gene name)
HarmonizomeHTR3A
DataMed IndexHTR3A
Probes
Litterature
PubMed140 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHTR3A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 25 19:25:55 CET 2021
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