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HTR3A (5-hydroxytryptamine receptor 3A)

Identity

Alias_namesHTR3
5-hydroxytryptamine (serotonin) receptor 3A
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
Alias_symbol (synonym)5-HT3R
5-HT3A
Other alias5-HT-3
5HT3R
HGNC (Hugo) HTR3A
LocusID (NCBI) 3359
Atlas_Id 45674
Location 11q23.2  [Link to chromosome band 11q23]
Location_base_pair Starts at 113845797 and ends at 113861034 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HTR3A   5297
Cards
Entrez_Gene (NCBI)HTR3A  3359  5-hydroxytryptamine receptor 3A
Aliases5-HT-3; 5-HT3A; 5-HT3R; 5HT3R; 
HTR3
GeneCards (Weizmann)HTR3A
Ensembl hg19 (Hinxton)ENSG00000166736 [Gene_View]  chr11:113845797-113861034 [Contig_View]  HTR3A [Vega]
Ensembl hg38 (Hinxton)ENSG00000166736 [Gene_View]  chr11:113845797-113861034 [Contig_View]  HTR3A [Vega]
ICGC DataPortalENSG00000166736
TCGA cBioPortalHTR3A
AceView (NCBI)HTR3A
Genatlas (Paris)HTR3A
WikiGenes3359
SOURCE (Princeton)HTR3A
Genetics Home Reference (NIH)HTR3A
Genomic and cartography
GoldenPath hg19 (UCSC)HTR3A  -     chr11:113845797-113861034 +  11q23.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HTR3A  -     11q23.2   [Description]    (hg38-Dec_2013)
EnsemblHTR3A - 11q23.2 [CytoView hg19]  HTR3A - 11q23.2 [CytoView hg38]
Mapping of homologs : NCBIHTR3A [Mapview hg19]  HTR3A [Mapview hg38]
OMIM182139   
Gene and transcription
Genbank (Entrez)AF498984 AJ003078 AJ003079 AJ003080 AJ003080
RefSeq transcript (Entrez)NM_000869 NM_001161772 NM_213621
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_013058 NT_033899 NW_004929381
Consensus coding sequences : CCDS (NCBI)HTR3A
Cluster EST : UnigeneHs.413899 [ NCBI ]
CGAP (NCI)Hs.413899
Alternative Splicing GalleryENSG00000166736
Gene ExpressionHTR3A [ NCBI-GEO ]   HTR3A [ EBI - ARRAY_EXPRESS ]   HTR3A [ SEEK ]   HTR3A [ MEM ]
Gene Expression Viewer (FireBrowse)HTR3A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3359
GTEX Portal (Tissue expression)HTR3A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46098   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP46098  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP46098
Splice isoforms : SwissVarP46098
PhosPhoSitePlusP46098
Domaine pattern : Prosite (Expaxy)NEUROTR_ION_CHANNEL (PS00236)   
Domains : Interpro (EBI)5HT3_rcpt    5HT3_rcpt_A    Acetylcholine_rcpt_TM    Neur_chan_lig-bd    Neur_channel    Neurotrans-gated_channel_TM    Neurotransmitter_ion_chnl_CS   
Domain families : Pfam (Sanger)Neur_chan_LBD (PF02931)    Neur_chan_memb (PF02932)   
Domain families : Pfam (NCBI)pfam02931    pfam02932   
Conserved Domain (NCBI)HTR3A
DMDM Disease mutations3359
Blocks (Seattle)HTR3A
SuperfamilyP46098
Human Protein AtlasENSG00000166736
Peptide AtlasP46098
HPRD08917
IPIIPI00748737   IPI00179555   IPI00963953   IPI00465351   IPI00967831   IPI01014761   
Protein Interaction databases
DIP (DOE-UCLA)P46098
IntAct (EBI)P46098
FunCoupENSG00000166736
BioGRIDHTR3A
STRING (EMBL)HTR3A
ZODIACHTR3A
Ontologies - Pathways
QuickGOP46098
Ontology : AmiGOreceptor activity  acetylcholine-activated cation-selective channel activity  G-protein coupled serotonin receptor activity  serotonin-activated cation-selective channel activity  voltage-gated potassium channel activity  protein binding  cytoplasm  plasma membrane  integral component of plasma membrane  acetylcholine-gated channel complex  transport  serotonin receptor signaling pathway  synaptic transmission  synaptic transmission, cholinergic  digestion  acetylcholine receptor activity  cell junction  axon  ion transmembrane transport  acetylcholine binding  response to cocaine  neuronal cell body  postsynaptic membrane  response to ethanol  serotonin binding  cellular response to growth factor stimulus  potassium ion transmembrane transport  
Ontology : EGO-EBIreceptor activity  acetylcholine-activated cation-selective channel activity  G-protein coupled serotonin receptor activity  serotonin-activated cation-selective channel activity  voltage-gated potassium channel activity  protein binding  cytoplasm  plasma membrane  integral component of plasma membrane  acetylcholine-gated channel complex  transport  serotonin receptor signaling pathway  synaptic transmission  synaptic transmission, cholinergic  digestion  acetylcholine receptor activity  cell junction  axon  ion transmembrane transport  acetylcholine binding  response to cocaine  neuronal cell body  postsynaptic membrane  response to ethanol  serotonin binding  cellular response to growth factor stimulus  potassium ion transmembrane transport  
Pathways : KEGGSerotonergic synapse   
NDEx NetworkHTR3A
Atlas of Cancer Signalling NetworkHTR3A
Wikipedia pathwaysHTR3A
Orthology - Evolution
OrthoDB3359
GeneTree (enSembl)ENSG00000166736
Phylogenetic Trees/Animal Genes : TreeFamHTR3A
HOVERGENP46098
HOGENOMP46098
Homologs : HomoloGeneHTR3A
Homology/Alignments : Family Browser (UCSC)HTR3A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHTR3A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HTR3A
dbVarHTR3A
ClinVarHTR3A
1000_GenomesHTR3A 
Exome Variant ServerHTR3A
ExAC (Exome Aggregation Consortium)HTR3A (select the gene name)
Genetic variants : HAPMAP3359
Genomic Variants (DGV)HTR3A [DGVbeta]
DECIPHER (Syndromes)11:113845797-113861034  ENSG00000166736
CONAN: Copy Number AnalysisHTR3A 
Mutations
ICGC Data PortalHTR3A 
TCGA Data PortalHTR3A 
Broad Tumor PortalHTR3A
OASIS PortalHTR3A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHTR3A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHTR3A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HTR3A
DgiDB (Drug Gene Interaction Database)HTR3A
DoCM (Curated mutations)HTR3A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HTR3A (select a term)
intoGenHTR3A
Cancer3DHTR3A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182139   
Orphanet
MedgenHTR3A
Genetic Testing Registry HTR3A
NextProtP46098 [Medical]
TSGene3359
GENETestsHTR3A
Huge Navigator HTR3A [HugePedia]
snp3D : Map Gene to Disease3359
BioCentury BCIQHTR3A
ClinGenHTR3A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3359
Chemical/Pharm GKB GenePA29555
Clinical trialHTR3A
Miscellaneous
canSAR (ICR)HTR3A (select the gene name)
Probes
Litterature
PubMed120 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHTR3A
EVEXHTR3A
GoPubMedHTR3A
iHOPHTR3A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:10:00 CET 2017

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