HTR3A (5-hydroxytryptamine receptor 3A)

2007-02-01 Affiliation

Identity

HGNC

HTR3A

LOCATION

11q23.2

LOCUSID

3359

ALIAS

5-HT-3,5-HT3A,5-HT3R,5HT3R,HTR3

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3359
MIM: 182139
HGNC: 5297
Ensembl: ENSG00000166736

Variants:

dbSNP: 3359
ClinVar: 3359
TCGA: ENSG00000166736
COSMIC: HTR3A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000166736	ENST00000299961	P46098
ENSG00000166736	ENST00000355556	P46098
ENSG00000166736	ENST00000375498	P46098
ENSG00000166736	ENST00000504030	P46098
ENSG00000166736	ENST00000506841	P46098
ENSG00000166736	ENST00000510849	A0A0B4J205

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Taste transduction	KEGG	ko04742
Taste transduction	KEGG	hsa04742
Serotonergic synapse	KEGG	hsa04726
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
Ion channel transport	REACTOME	R-HSA-983712
Ligand-gated ion channel transport	REACTOME	R-HSA-975298

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA445208	Pain	Disease	VariantAnnotation	not associated	PD	21398039
PA447216	Schizophrenia	Disease	ClinicalAnnotation	associated	PD	20168265, 22700043
PA449061	clozapine	Chemical	ClinicalAnnotation	associated	PD	20168265, 22700043
PA449841	haloperidol	Chemical	MultilinkAnnotation	associated		27023437
PA452618	opioids	Chemical	VariantAnnotation	not associated	PD	21398039

References

Pubmed ID	Year	Title	Citations
12867984	2003	A cytoplasmic region determines single-channel conductance in 5-HT3 receptors.	116
18982004	2010	Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder.	101
19874574	2009	Genetical genomic determinants of alcohol consumption in rats and humans.	93
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
18614545	2008	First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome.	77
18614545	2008	First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome.	77
16407231	2006	Common determinants of single channel conductance within the large cytoplasmic loop of 5-hydroxytryptamine type 3 and alpha4beta2 nicotinic acetylcholine receptors.	46
19156168	2009	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	46
20838391	2011	Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependence.	37
19086053	2009	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	34

Citation

Dessen P

HTR3A (5-hydroxytryptamine receptor 3A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45674/htr3a