Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3359
MIM: 182139
HGNC: 5297
Ensembl: ENSG00000166736
Variants:
dbSNP: 3359
ClinVar: 3359
TCGA: ENSG00000166736
COSMIC: HTR3A
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA445208 | Pain | Disease | VariantAnnotation | not associated | PD | 21398039 | |
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | PD | 20168265, 22700043 | |
| PA449061 | clozapine | Chemical | ClinicalAnnotation | associated | PD | 20168265, 22700043 | |
| PA449841 | haloperidol | Chemical | MultilinkAnnotation | associated | 27023437 | ||
| PA452618 | opioids | Chemical | VariantAnnotation | not associated | PD | 21398039 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36769290 | 2023 | Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development. | 2 |
| 36769290 | 2023 | Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development. | 2 |
| 35413654 | 2022 | Fear reacquisition and symptoms of combat-related PTSD: Specificity and preliminary examination of the influence of the 5-HT3A receptor gene. | 1 |
| 35800179 | 2022 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome: A multicenter retrospective study. | 3 |
| 35413654 | 2022 | Fear reacquisition and symptoms of combat-related PTSD: Specificity and preliminary examination of the influence of the 5-HT3A receptor gene. | 1 |
| 35800179 | 2022 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome: A multicenter retrospective study. | 3 |
| 34202161 | 2021 | 5-HT3 Signaling Alters Development of Sacral Neural Crest Derivatives That Innervate the Lower Urinary Tract. | 4 |
| 34202161 | 2021 | 5-HT3 Signaling Alters Development of Sacral Neural Crest Derivatives That Innervate the Lower Urinary Tract. | 4 |
| 31868947 | 2020 | 5'UTR polymorphism in the serotonergic receptor HTR3A gene is differently associated with striatal Dopamine D2/D3 receptor availability in the right putamen in Fibromyalgia patients and healthy controls-Preliminary evidence. | 6 |
| 32736413 | 2020 | HTR3A is correlated with unfavorable histology and promotes proliferation through ERK phosphorylation in lung adenocarcinoma. | 8 |
| 32946769 | 2020 | Orthosteric and Allosteric Activation of Human 5-HT(3)A Receptors. | 4 |
| 33063666 | 2020 | High-resolution structures of multiple 5-HT(3A)R-setron complexes reveal a novel mechanism of competitive inhibition. | 18 |
| 31868947 | 2020 | 5'UTR polymorphism in the serotonergic receptor HTR3A gene is differently associated with striatal Dopamine D2/D3 receptor availability in the right putamen in Fibromyalgia patients and healthy controls-Preliminary evidence. | 6 |
| 32736413 | 2020 | HTR3A is correlated with unfavorable histology and promotes proliferation through ERK phosphorylation in lung adenocarcinoma. | 8 |
| 32946769 | 2020 | Orthosteric and Allosteric Activation of Human 5-HT(3)A Receptors. | 4 |
Citation
Dessen P
HTR3A (5-hydroxytryptamine receptor 3A)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45674/htr3a
