HTR3B (5-hydroxytryptamine receptor 3B)

2014-11-01  

Identity

HGNC
LOCATION
11q23.2
LOCUSID
ALIAS
5-HT3B

Other Information

Locus ID:

NCBI: 9177
MIM: 604654
HGNC: 5298
Ensembl: ENSG00000149305

Variants:

dbSNP: 9177
ClinVar: 9177
TCGA: ENSG00000149305
COSMIC: HTR3B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149305ENST00000260191O95264
ENSG00000149305ENST00000537778O95264
ENSG00000149305ENST00000543092H0YFX8

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Taste transductionKEGGko04742
Taste transductionKEGGhsa04742
Serotonergic synapseKEGGhsa04726
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Ligand-gated ion channel transportREACTOMER-HSA-975298

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10352palonosetronChemicalVariantAnnotationnot associatedPD29177570
PA157379134Myalgia unspecifiedDiseaseClinicalAnnotationassociatedPD17600820
PA444460Heroin DependenceDiseaseClinicalAnnotationassociatedPD
PA445048NauseaDiseaseVariantAnnotationnot associatedPD29177570, 29546524
PA445062NeoplasmsDiseaseVariantAnnotationnot associatedPD29546524
PA445208PainDiseaseVariantAnnotationnot associatedPD21398039
PA445876Tobacco Use DisorderDiseaseClinicalAnnotationassociatedPD
PA446051VomitingDiseaseVariantAnnotationnot associatedPD29177570, 29546524
PA447208Mental DisordersDiseaseClinicalAnnotationassociatedPKPD16534507, 20075642
PA448500atorvastatinChemicalClinicalAnnotationassociatedPD17600820
PA449809granisetronChemicalVariantAnnotationnot associatedPD29177570
PA450626nicotineChemicalClinicalAnnotationassociatedPD
PA450801paroxetineChemicalClinicalAnnotationassociatedPKPD16534507, 20075642
PA451089pravastatinChemicalClinicalAnnotationassociatedPD17600820
PA451363simvastatinChemicalClinicalAnnotationassociatedPD17600820
PA452618opioidsChemicalVariantAnnotationnot associatedPD21398039
PA452619heroinChemicalClinicalAnnotationassociatedPD
PA452621antineoplastic agentsChemicalVariantAnnotationnot associatedPD29546524

References

Pubmed IDYearTitleCitations
128679842003A cytoplasmic region determines single-channel conductance in 5-HT3 receptors.116
189820042010Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder.101
185189252008Genetic susceptibility to heroin addiction: a candidate gene association study.99
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
203517142011Poor replication of candidate genes for major depressive disorder using genome-wide association data.92
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
189378422008The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis.63
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
208383912011Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependence.37
208383912011Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependence.37

Citation

Dessen P

HTR3B (5-hydroxytryptamine receptor 3B)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64468/htr3b