HTR3C (5-hydroxytryptamine receptor 3C)

2014-11-01  

Identity

HGNC
LOCATION
3q27.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 170572
MIM: 610121
HGNC: 24003
Ensembl: ENSG00000178084

Variants:

dbSNP: 170572
ClinVar: 170572
TCGA: ENSG00000178084
COSMIC: HTR3C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178084ENST00000318351Q8WXA8

Expression (GTEx)

0
1
2
3

Pathways

PathwaySourceExternal ID
Taste transductionKEGGko04742
Taste transductionKEGGhsa04742
Serotonergic synapseKEGGhsa04726
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Ligand-gated ion channel transportREACTOMER-HSA-975298

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10352palonosetronChemicalVariantAnnotationnot associatedPD29177570
PA445048NauseaDiseaseVariantAnnotationnot associatedPD29177570
PA446051VomitingDiseaseVariantAnnotationnot associatedPD29177570
PA449809granisetronChemicalVariantAnnotationnot associatedPD29177570

References

Pubmed IDYearTitleCitations
205389602010A candidate gene study of obstructive sleep apnea in European Americans and African Americans.30
211920762011Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E.14
183892802008Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy.13
183892802008Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy.13
197943302009Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia.7
200212652010Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy.6
200212652010Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy.6
203567182010A coding variant of the novel serotonin receptor subunit 5-HT3E influences sustained attention in schizophrenia patients.6
2392829420145-HT3 receptor influences the washing phenotype and visual organization in obsessive-compulsive disorder supporting 5-HT3 receptor antagonists as novel treatment option.5
186817792008Investigation of HTR3C mutations for association with 5HT(3) receptor antagonist anti-emetic efficacy.3

Citation

Dessen P

HTR3C (5-hydroxytryptamine receptor 3C)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64469/htr3c