HTR3D (5-hydroxytryptamine receptor 3D)

2014-11-01 Affiliation

Identity

HGNC

HTR3D

LOCATION

3q27.1

LOCUSID

200909

ALIAS

5HT3D

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 200909
MIM: 610122
HGNC: 24004
Ensembl: ENSG00000186090

Variants:

dbSNP: 200909
ClinVar: 200909
TCGA: ENSG00000186090
COSMIC: HTR3D

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000186090	ENST00000334128	F6WC43
ENSG00000186090	ENST00000382489	Q70Z44
ENSG00000186090	ENST00000428798	Q70Z44
ENSG00000186090	ENST00000453435	Q70Z44

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Taste transduction	KEGG	ko04742
Taste transduction	KEGG	hsa04742
Serotonergic synapse	KEGG	hsa04726
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
Ion channel transport	REACTOME	R-HSA-983712
Ligand-gated ion channel transport	REACTOME	R-HSA-975298

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
20538960	2010	A candidate gene study of obstructive sleep apnea in European Americans and African Americans.	30
21192076	2011	Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E.	14
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11
19794330	2009	Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia.	7
20021265	2010	Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy.	6
20356718	2010	A coding variant of the novel serotonin receptor subunit 5-HT3E influences sustained attention in schizophrenia patients.	6
20602613	2010	Polymorphism in HTR3D shows different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy.	5
20602613	2010	Polymorphism in HTR3D shows different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy.	5
28813580	2017	Genetic Association of the PARL-ABCC5-HTR3D-HTR3C Locus With Primary Angle-Closure Glaucoma in Chinese.	0

Citation

Dessen P

HTR3D (5-hydroxytryptamine receptor 3D)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64470/htr3d