HTR3E (5-hydroxytryptamine receptor 3E)

2014-11-01  

Identity

HGNC
LOCATION
3q27.1
LOCUSID
ALIAS
5-HT3-E,5-HT3E,5-HT3c1

Other Information

Locus ID:

NCBI: 285242
MIM: 610123
HGNC: 24005
Ensembl: ENSG00000186038

Variants:

dbSNP: 285242
ClinVar: 285242
TCGA: ENSG00000186038
COSMIC: HTR3E

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186038ENST00000335304A5X5Y0
ENSG00000186038ENST00000415389A5X5Y0
ENSG00000186038ENST00000425359A5X5Y0
ENSG00000186038ENST00000431041C9J420
ENSG00000186038ENST00000436361A5X5Y0
ENSG00000186038ENST00000440596A5X5Y0

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Taste transductionKEGGko04742
Taste transductionKEGGhsa04742
Serotonergic synapseKEGGhsa04726
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Ligand-gated ion channel transportREACTOMER-HSA-975298

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA449841haloperidolChemicalMultilinkAnnotationassociated27023437

References

Pubmed IDYearTitleCitations
186145452008First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome.77
186145452008First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome.77
205389602010A candidate gene study of obstructive sleep apnea in European Americans and African Americans.30
211920762011Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E.14
185732762009Central 5-HT receptors in cardiovascular control during stress.12
197943302009Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia.7
200212652010Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy.6
203567182010A coding variant of the novel serotonin receptor subunit 5-HT3E influences sustained attention in schizophrenia patients.6
203567182010A coding variant of the novel serotonin receptor subunit 5-HT3E influences sustained attention in schizophrenia patients.6
206026132010Polymorphism in HTR3D shows different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy.5

Citation

Dessen P

HTR3E (5-hydroxytryptamine receptor 3E)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64471/htr3e