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HTR4 (5-hydroxytryptamine receptor 4)

Identity

Alias_names5-hydroxytryptamine (serotonin) receptor 4
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
Alias_symbol (synonym)5-HT4
Other alias5-HT4R
HGNC (Hugo) HTR4
LocusID (NCBI) 3360
Atlas_Id 52727
Location 5q32  [Link to chromosome band 5q32]
Location_base_pair Starts at 148481552 and ends at 148654527 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HTR4 (5q32) / ST3GAL1 (8q24.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HTR4   5299
Cards
Entrez_Gene (NCBI)HTR4  3360  5-hydroxytryptamine receptor 4
Aliases5-HT4; 5-HT4R
GeneCards (Weizmann)HTR4
Ensembl hg19 (Hinxton)ENSG00000164270 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164270 [Gene_View]  chr5:148481552-148654527 [Contig_View]  HTR4 [Vega]
ICGC DataPortalENSG00000164270
TCGA cBioPortalHTR4
AceView (NCBI)HTR4
Genatlas (Paris)HTR4
WikiGenes3360
SOURCE (Princeton)HTR4
Genetics Home Reference (NIH)HTR4
Genomic and cartography
GoldenPath hg38 (UCSC)HTR4  -     chr5:148481552-148654527 -  5q32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HTR4  -     5q32   [Description]    (hg19-Feb_2009)
EnsemblHTR4 - 5q32 [CytoView hg19]  HTR4 - 5q32 [CytoView hg38]
Mapping of homologs : NCBIHTR4 [Mapview hg19]  HTR4 [Mapview hg38]
OMIM602164   
Gene and transcription
Genbank (Entrez)AJ011371 AJ131724 AJ131725 AJ131726 AJ278979
RefSeq transcript (Entrez)NM_000870 NM_001040169 NM_001040172 NM_001040173 NM_001040174 NM_001286410 NM_199453
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HTR4
Cluster EST : UnigeneHs.483773 [ NCBI ]
CGAP (NCI)Hs.483773
Alternative Splicing GalleryENSG00000164270
Gene ExpressionHTR4 [ NCBI-GEO ]   HTR4 [ EBI - ARRAY_EXPRESS ]   HTR4 [ SEEK ]   HTR4 [ MEM ]
Gene Expression Viewer (FireBrowse)HTR4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3360
GTEX Portal (Tissue expression)HTR4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13639   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13639  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13639
Splice isoforms : SwissVarQ13639
PhosPhoSitePlusQ13639
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)5HT4_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)HTR4
DMDM Disease mutations3360
Blocks (Seattle)HTR4
SuperfamilyQ13639
Human Protein AtlasENSG00000164270
Peptide AtlasQ13639
IPIIPI00014378   IPI00064638   IPI00216427   IPI00186777   IPI00216429   IPI00291659   IPI00216428   IPI00984861   IPI00974551   IPI00748585   
Protein Interaction databases
DIP (DOE-UCLA)Q13639
IntAct (EBI)Q13639
FunCoupENSG00000164270
BioGRIDHTR4
STRING (EMBL)HTR4
ZODIACHTR4
Ontologies - Pathways
QuickGOQ13639
Ontology : AmiGOtrace-amine receptor activity  G-protein coupled serotonin receptor activity  cytoplasm  endosome  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  gamma-aminobutyric acid signaling pathway  chemical synaptic transmission  membrane  regulation of appetite  G-protein coupled serotonin receptor signaling pathway  
Ontology : EGO-EBItrace-amine receptor activity  G-protein coupled serotonin receptor activity  cytoplasm  endosome  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  gamma-aminobutyric acid signaling pathway  chemical synaptic transmission  membrane  regulation of appetite  G-protein coupled serotonin receptor signaling pathway  
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction    Serotonergic synapse   
NDEx NetworkHTR4
Atlas of Cancer Signalling NetworkHTR4
Wikipedia pathwaysHTR4
Orthology - Evolution
OrthoDB3360
GeneTree (enSembl)ENSG00000164270
Phylogenetic Trees/Animal Genes : TreeFamHTR4
HOVERGENQ13639
HOGENOMQ13639
Homologs : HomoloGeneHTR4
Homology/Alignments : Family Browser (UCSC)HTR4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHTR4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HTR4
dbVarHTR4
ClinVarHTR4
1000_GenomesHTR4 
Exome Variant ServerHTR4
ExAC (Exome Aggregation Consortium)HTR4 (select the gene name)
Genetic variants : HAPMAP3360
Genomic Variants (DGV)HTR4 [DGVbeta]
DECIPHERHTR4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHTR4 
Mutations
ICGC Data PortalHTR4 
TCGA Data PortalHTR4 
Broad Tumor PortalHTR4
OASIS PortalHTR4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHTR4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHTR4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HTR4
DgiDB (Drug Gene Interaction Database)HTR4
DoCM (Curated mutations)HTR4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HTR4 (select a term)
intoGenHTR4
Cancer3DHTR4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602164   
Orphanet
MedgenHTR4
Genetic Testing Registry HTR4
NextProtQ13639 [Medical]
TSGene3360
GENETestsHTR4
Target ValidationHTR4
Huge Navigator HTR4 [HugePedia]
snp3D : Map Gene to Disease3360
BioCentury BCIQHTR4
ClinGenHTR4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3360
Chemical/Pharm GKB GenePA29557
Clinical trialHTR4
Miscellaneous
canSAR (ICR)HTR4 (select the gene name)
Probes
Litterature
PubMed86 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHTR4
EVEXHTR4
GoPubMedHTR4
iHOPHTR4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:37:45 CEST 2017

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