HTR7 (5-hydroxytryptamine receptor 7)

2014-11-01 Affiliation

Identity

HGNC

HTR7

LOCATION

10q23.31

LOCUSID

3363

ALIAS

5-HT7

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3363
MIM: 182137
HGNC: 5302
Ensembl: ENSG00000148680

Variants:

dbSNP: 3363
ClinVar: 3363
TCGA: ENSG00000148680
COSMIC: HTR7

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000148680	ENST00000277874	P34969
ENSG00000148680	ENST00000336152	P34969
ENSG00000148680	ENST00000371719	P34969

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Neuroactive ligand-receptor interaction	KEGG	ko04080
Calcium signaling pathway	KEGG	hsa04020
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Serotonergic synapse	KEGG	hsa04726
Ras signaling pathway	KEGG	hsa04014
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Amine ligand-binding receptors	REACTOME	R-HSA-375280
Serotonin receptors	REACTOME	R-HSA-390666
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555

Protein levels (Protein atlas)

Not detected

Low

Medium

High

cerebral cortex

cerebellum

hippocampus

caudate

hypothalamus

thyroid gland

parathyroid gland

adrenal gland

nasopharynx

bronchus

lung

oral mucosa

salivary gland

esophagus

stomach 1

stomach 2

duodenum

small intestine

colon

rectum

liver

gallbladder

pancreas

kidney

urinary bladder

testis

epididymis

seminal vesicle

prostate

vagina

ovary

fallopian tube

endometrium 1

endometrium 2

cervix, uterine

placenta

breast

heart muscle

smooth muscle

skeletal muscle

soft tissue 1

soft tissue 2

adipose tissue

skin 1

skin 2

appendix

spleen

lymph node

tonsil

bone marrow

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA133950441	hmg coa reductase inhibitors	Chemical	ClinicalAnnotation	associated	PD	17600820
PA157379134	Myalgia unspecified	Disease	ClinicalAnnotation	associated	PD	17600820
PA164713257	Selective serotonin reuptake inhibitors	Chemical	ClinicalAnnotation	associated	PD	30874608
PA175	GNAS	Gene	Pathway	associated		19741567
PA447278	Depression	Disease	ClinicalAnnotation	associated	PD	30874608
PA448500	atorvastatin	Chemical	ClinicalAnnotation	associated	PD	17600820
PA451089	pravastatin	Chemical	ClinicalAnnotation	associated	PD	17600820
PA451363	simvastatin	Chemical	ClinicalAnnotation	associated	PD	17600820

References

Pubmed ID	Year	Title	Citations
16385451	2006	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	69
12767050	2003	Functional activity of serotoninergic and melatoninergic systems expressed in the skin.	61
19156168	2009	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	46
21184583	2011	Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence.	39
23355731	2013	Serotonin skews human macrophage polarization through HTR2B and HTR7.	37
19086053	2009	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	34
20468064	2010	Association study of 182 candidate genes in anorexia nervosa.	30
18855532	2008	Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia.	29
21424680	2011	Role of the 5-HT7 receptor in the central nervous system: from current status to future perspectives.	26
18079067	2008	Genetic evaluation of the serotonergic system in chronic fatigue syndrome.	23

Citation

Dessen P

HTR7 (5-hydroxytryptamine receptor 7)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64475/htr7