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HTRA4 (HtrA serine peptidase 4)

Identity

Alias_symbol (synonym)FLJ90724
Other alias-
HGNC (Hugo) HTRA4
LocusID (NCBI) 203100
Atlas_Id 52757
Location 8p11.22  [Link to chromosome band 8p11]
Location_base_pair Starts at 38831668 and ends at 38846181 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RAB11FIP1 (8p11.23) / HTRA4 (8p11.22)RAB11FIP1 8p11.23 / HTRA4 8p11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HTRA4   26909
Cards
Entrez_Gene (NCBI)HTRA4  203100  HtrA serine peptidase 4
Aliases
GeneCards (Weizmann)HTRA4
Ensembl hg19 (Hinxton)ENSG00000169495 [Gene_View]  chr8:38831668-38846181 [Contig_View]  HTRA4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000169495 [Gene_View]  chr8:38831668-38846181 [Contig_View]  HTRA4 [Vega]
ICGC DataPortalENSG00000169495
TCGA cBioPortalHTRA4
AceView (NCBI)HTRA4
Genatlas (Paris)HTRA4
WikiGenes203100
SOURCE (Princeton)HTRA4
Genetics Home Reference (NIH)HTRA4
Genomic and cartography
GoldenPath hg19 (UCSC)HTRA4  -     chr8:38831668-38846181 +  8p11.22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HTRA4  -     8p11.22   [Description]    (hg38-Dec_2013)
EnsemblHTRA4 - 8p11.22 [CytoView hg19]  HTRA4 - 8p11.22 [CytoView hg38]
Mapping of homologs : NCBIHTRA4 [Mapview hg19]  HTRA4 [Mapview hg38]
OMIM610700   
Gene and transcription
Genbank (Entrez)AK075205 AK300197 AY188774 BC057765 DC423042
RefSeq transcript (Entrez)NM_153692
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_167187 NW_004929337
Consensus coding sequences : CCDS (NCBI)HTRA4
Cluster EST : UnigeneHs.661014 [ NCBI ]
CGAP (NCI)Hs.661014
Alternative Splicing GalleryENSG00000169495
Gene ExpressionHTRA4 [ NCBI-GEO ]   HTRA4 [ EBI - ARRAY_EXPRESS ]   HTRA4 [ SEEK ]   HTRA4 [ MEM ]
Gene Expression Viewer (FireBrowse)HTRA4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)203100
GTEX Portal (Tissue expression)HTRA4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP83105   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP83105  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP83105
Splice isoforms : SwissVarP83105
Catalytic activity : Enzyme3.4.21.- [ Enzyme-Expasy ]   3.4.21.-3.4.21.- [ IntEnz-EBI ]   3.4.21.- [ BRENDA ]   3.4.21.- [ KEGG ]   
PhosPhoSitePlusP83105
Domaine pattern : Prosite (Expaxy)IGFBP_N_2 (PS51323)    KAZAL_2 (PS51465)    PDZ (PS50106)   
Domains : Interpro (EBI)Growth_fac_rcpt_    IGFBP-like    Kazal_dom    PDZ    Peptidase_S1_PA    Peptidase_S1C   
Domain families : Pfam (Sanger)IGFBP (PF00219)    Kazal_2 (PF07648)    PDZ_2 (PF13180)   
Domain families : Pfam (NCBI)pfam00219    pfam07648    pfam13180   
Domain families : Smart (EMBL)KAZAL (SM00280)  PDZ (SM00228)  
Conserved Domain (NCBI)HTRA4
DMDM Disease mutations203100
Blocks (Seattle)HTRA4
SuperfamilyP83105
Human Protein AtlasENSG00000169495
Peptide AtlasP83105
HPRD08818
IPIIPI00027860   
Protein Interaction databases
DIP (DOE-UCLA)P83105
IntAct (EBI)P83105
FunCoupENSG00000169495
BioGRIDHTRA4
STRING (EMBL)HTRA4
ZODIACHTRA4
Ontologies - Pathways
QuickGOP83105
Ontology : AmiGOregulation of cell growth  endopeptidase activity  serine-type endopeptidase activity  insulin-like growth factor binding  extracellular region  proteolysis  negative regulation of transforming growth factor beta receptor signaling pathway  
Ontology : EGO-EBIregulation of cell growth  endopeptidase activity  serine-type endopeptidase activity  insulin-like growth factor binding  extracellular region  proteolysis  negative regulation of transforming growth factor beta receptor signaling pathway  
NDEx NetworkHTRA4
Atlas of Cancer Signalling NetworkHTRA4
Wikipedia pathwaysHTRA4
Orthology - Evolution
OrthoDB203100
GeneTree (enSembl)ENSG00000169495
Phylogenetic Trees/Animal Genes : TreeFamHTRA4
HOVERGENP83105
HOGENOMP83105
Homologs : HomoloGeneHTRA4
Homology/Alignments : Family Browser (UCSC)HTRA4
Gene fusions - Rearrangements
Fusion : MitelmanRAB11FIP1/HTRA4 [8p11.23/8p11.22]  [t(8;8)(p11;p11)]  
Fusion: TCGARAB11FIP1 8p11.23 HTRA4 8p11.22 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHTRA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HTRA4
dbVarHTRA4
ClinVarHTRA4
1000_GenomesHTRA4 
Exome Variant ServerHTRA4
ExAC (Exome Aggregation Consortium)HTRA4 (select the gene name)
Genetic variants : HAPMAP203100
Genomic Variants (DGV)HTRA4 [DGVbeta]
DECIPHER (Syndromes)8:38831668-38846181  ENSG00000169495
CONAN: Copy Number AnalysisHTRA4 
Mutations
ICGC Data PortalHTRA4 
TCGA Data PortalHTRA4 
Broad Tumor PortalHTRA4
OASIS PortalHTRA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHTRA4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHTRA4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HTRA4
DgiDB (Drug Gene Interaction Database)HTRA4
DoCM (Curated mutations)HTRA4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HTRA4 (select a term)
intoGenHTRA4
Cancer3DHTRA4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610700   
Orphanet
MedgenHTRA4
Genetic Testing Registry HTRA4
NextProtP83105 [Medical]
TSGene203100
GENETestsHTRA4
Huge Navigator HTRA4 [HugePedia]
snp3D : Map Gene to Disease203100
BioCentury BCIQHTRA4
ClinGenHTRA4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD203100
Chemical/Pharm GKB GenePA134862039
Clinical trialHTRA4
Miscellaneous
canSAR (ICR)HTRA4 (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHTRA4
EVEXHTRA4
GoPubMedHTRA4
iHOPHTRA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:10:00 CET 2017

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