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HUNK (hormonally up-regulated Neu-associated kinase)

Identity

Alias (NCBI)-
HGNC (Hugo) HUNK
HGNC Previous namehormonally upregulated Neu-associated kinase
LocusID (NCBI) 30811
Atlas_Id 43311
Location 21q22.11  [Link to chromosome band 21q22]
Location_base_pair Starts at 31873020 and ends at 32004064 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BRWD1 (21q22.2) / HUNK (21q22.11)HUNK (21q22.11) / CNOT10 (3p22.3)HUNK (21q22.11) / MAMLD1 (Xq28)
SIK1 (21q22.3) / HUNK (21q22.11)BRWD1 21q22.2 / HUNK 21q22.11HUNK 21q22.11 / MAMLD1 Xq28
SIK1 21q22.3 / HUNK 21q22.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)HUNK   13326
Cards
Entrez_Gene (NCBI)HUNK    hormonally up-regulated Neu-associated kinase
Aliases
GeneCards (Weizmann)HUNK
Ensembl hg19 (Hinxton)ENSG00000142149 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142149 [Gene_View]  ENSG00000142149 [Sequence]  chr21:31873020-32004064 [Contig_View]  HUNK [Vega]
ICGC DataPortalENSG00000142149
TCGA cBioPortalHUNK
AceView (NCBI)HUNK
Genatlas (Paris)HUNK
SOURCE (Princeton)HUNK
Genetics Home Reference (NIH)HUNK
Genomic and cartography
GoldenPath hg38 (UCSC)HUNK  -     chr21:31873020-32004064 +  21q22.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HUNK  -     21q22.11   [Description]    (hg19-Feb_2009)
GoldenPathHUNK - 21q22.11 [CytoView hg19]  HUNK - 21q22.11 [CytoView hg38]
ImmunoBaseENSG00000142149
Genome Data Viewer NCBIHUNK [Mapview hg19]  
OMIM606532   
Gene and transcription
Genbank (Entrez)AF086072 AJ271722
RefSeq transcript (Entrez)NM_014586
Consensus coding sequences : CCDS (NCBI)HUNK
Gene ExpressionHUNK [ NCBI-GEO ]   HUNK [ EBI - ARRAY_EXPRESS ]   HUNK [ SEEK ]   HUNK [ MEM ]
Gene Expression Viewer (FireBrowse)HUNK [ Firebrowse - Broad ]
GenevisibleExpression of HUNK in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)30811
GTEX Portal (Tissue expression)HUNK
Human Protein AtlasENSG00000142149-HUNK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP57058   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP57058  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP57058
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP57058
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Hunk    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)HUNK
SuperfamilyP57058
AlphaFold pdb e-kbP57058   
Human Protein Atlas [tissue]ENSG00000142149-HUNK [tissue]
HPRD09410
Protein Interaction databases
DIP (DOE-UCLA)P57058
IntAct (EBI)P57058
BioGRIDHUNK
STRING (EMBL)HUNK
ZODIACHUNK
Ontologies - Pathways
QuickGOP57058
Ontology : AmiGOprotein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  protein phosphorylation  signal transduction  multicellular organism development  intracellular signal transduction  protein serine kinase activity  protein threonine kinase activity  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  protein phosphorylation  signal transduction  multicellular organism development  intracellular signal transduction  protein serine kinase activity  protein threonine kinase activity  
NDEx NetworkHUNK
Atlas of Cancer Signalling NetworkHUNK
Wikipedia pathwaysHUNK
Orthology - Evolution
OrthoDB30811
GeneTree (enSembl)ENSG00000142149
Phylogenetic Trees/Animal Genes : TreeFamHUNK
Homologs : HomoloGeneHUNK
Homology/Alignments : Family Browser (UCSC)HUNK
Gene fusions - Rearrangements
Fusion : MitelmanBRWD1/HUNK [21q22.2/21q22.11]  
Fusion : MitelmanHUNK/MAMLD1 [21q22.11/Xq28]  
Fusion : MitelmanSIK1/HUNK [21q22.3/21q22.11]  
Fusion : QuiverHUNK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHUNK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HUNK
dbVarHUNK
ClinVarHUNK
MonarchHUNK
1000_GenomesHUNK 
Exome Variant ServerHUNK
GNOMAD BrowserENSG00000142149
Varsome BrowserHUNK
ACMGHUNK variants
VarityP57058
Genomic Variants (DGV)HUNK [DGVbeta]
DECIPHERHUNK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHUNK 
Mutations
ICGC Data PortalHUNK 
TCGA Data PortalHUNK 
Broad Tumor PortalHUNK
OASIS PortalHUNK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHUNK  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHUNK
Mutations and Diseases : HGMDHUNK
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaHUNK
DgiDB (Drug Gene Interaction Database)HUNK
DoCM (Curated mutations)HUNK
CIViC (Clinical Interpretations of Variants in Cancer)HUNK
Cancer3DHUNK
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606532   
Orphanet
DisGeNETHUNK
MedgenHUNK
Genetic Testing Registry HUNK
NextProtP57058 [Medical]
GENETestsHUNK
Target ValidationHUNK
Huge Navigator HUNK [HugePedia]
ClinGenHUNK
Clinical trials, drugs, therapy
MyCancerGenomeHUNK
Protein Interactions : CTDHUNK
Pharm GKB GenePA29563
PharosP57058
Clinical trialHUNK
Miscellaneous
canSAR (ICR)HUNK
HarmonizomeHUNK
DataMed IndexHUNK
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXHUNK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:13:14 CEST 2021

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