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HUNK (hormonally up-regulated Neu-associated kinase)

Identity

Alias_nameshormonally upregulated Neu-associated kinase
Other alias-
HGNC (Hugo) HUNK
LocusID (NCBI) 30811
Atlas_Id 43311
Location 21q22.11  [Link to chromosome band 21q22]
Location_base_pair Starts at 31873315 and ends at 32004064 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BRWD1 (21q22.2) / HUNK (21q22.11)HUNK (21q22.11) / CNOT10 (3p22.3)HUNK (21q22.11) / MAMLD1 (Xq28)
SIK1 (21q22.3) / HUNK (21q22.11)BRWD1 21q22.2 / HUNK 21q22.11HUNK 21q22.11 / MAMLD1 Xq28
SIK1 21q22.3 / HUNK 21q22.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HUNK   13326
Cards
Entrez_Gene (NCBI)HUNK  30811  hormonally up-regulated Neu-associated kinase
Aliases
GeneCards (Weizmann)HUNK
Ensembl hg19 (Hinxton)ENSG00000142149 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142149 [Gene_View]  chr21:31873315-32004064 [Contig_View]  HUNK [Vega]
ICGC DataPortalENSG00000142149
TCGA cBioPortalHUNK
AceView (NCBI)HUNK
Genatlas (Paris)HUNK
WikiGenes30811
SOURCE (Princeton)HUNK
Genetics Home Reference (NIH)HUNK
Genomic and cartography
GoldenPath hg38 (UCSC)HUNK  -     chr21:31873315-32004064 +  21q22.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HUNK  -     21q22.11   [Description]    (hg19-Feb_2009)
EnsemblHUNK - 21q22.11 [CytoView hg19]  HUNK - 21q22.11 [CytoView hg38]
Mapping of homologs : NCBIHUNK [Mapview hg19]  HUNK [Mapview hg38]
OMIM606532   
Gene and transcription
Genbank (Entrez)AF086072 AJ271722 BC156532 BC172525
RefSeq transcript (Entrez)NM_014586
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)HUNK
Cluster EST : UnigeneHs.109437 [ NCBI ]
CGAP (NCI)Hs.109437
Alternative Splicing GalleryENSG00000142149
Gene ExpressionHUNK [ NCBI-GEO ]   HUNK [ EBI - ARRAY_EXPRESS ]   HUNK [ SEEK ]   HUNK [ MEM ]
Gene Expression Viewer (FireBrowse)HUNK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)30811
GTEX Portal (Tissue expression)HUNK
Protein : pattern, domain, 3D structure
UniProt/SwissProtP57058   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP57058  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP57058
Splice isoforms : SwissVarP57058
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusP57058
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)HUNK
DMDM Disease mutations30811
Blocks (Seattle)HUNK
SuperfamilyP57058
Human Protein AtlasENSG00000142149
Peptide AtlasP57058
HPRD09410
IPIIPI00219553   IPI00793740   IPI00794382   
Protein Interaction databases
DIP (DOE-UCLA)P57058
IntAct (EBI)P57058
FunCoupENSG00000142149
BioGRIDHUNK
STRING (EMBL)HUNK
ZODIACHUNK
Ontologies - Pathways
QuickGOP57058
Ontology : AmiGOprotein serine/threonine kinase activity  ATP binding  nucleus  cytoplasm  protein phosphorylation  signal transduction  multicellular organism development  intracellular signal transduction  
Ontology : EGO-EBIprotein serine/threonine kinase activity  ATP binding  nucleus  cytoplasm  protein phosphorylation  signal transduction  multicellular organism development  intracellular signal transduction  
NDEx NetworkHUNK
Atlas of Cancer Signalling NetworkHUNK
Wikipedia pathwaysHUNK
Orthology - Evolution
OrthoDB30811
GeneTree (enSembl)ENSG00000142149
Phylogenetic Trees/Animal Genes : TreeFamHUNK
HOVERGENP57058
HOGENOMP57058
Homologs : HomoloGeneHUNK
Homology/Alignments : Family Browser (UCSC)HUNK
Gene fusions - Rearrangements
Fusion : MitelmanBRWD1/HUNK [21q22.2/21q22.11]  [t(21;21)(q22;q22)]  
Fusion : MitelmanHUNK/MAMLD1 [21q22.11/Xq28]  [t(X;21)(q28;q22)]  
Fusion : MitelmanSIK1/HUNK [21q22.3/21q22.11]  [t(21;21)(q22;q22)]  
Fusion: TCGABRWD1 21q22.2 HUNK 21q22.11 LUAD
Fusion: TCGAHUNK 21q22.11 MAMLD1 Xq28 KIRC
Fusion: TCGASIK1 21q22.3 HUNK 21q22.11 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHUNK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HUNK
dbVarHUNK
ClinVarHUNK
1000_GenomesHUNK 
Exome Variant ServerHUNK
ExAC (Exome Aggregation Consortium)HUNK (select the gene name)
Genetic variants : HAPMAP30811
Genomic Variants (DGV)HUNK [DGVbeta]
DECIPHERHUNK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHUNK 
Mutations
ICGC Data PortalHUNK 
TCGA Data PortalHUNK 
Broad Tumor PortalHUNK
OASIS PortalHUNK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHUNK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHUNK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HUNK
DgiDB (Drug Gene Interaction Database)HUNK
DoCM (Curated mutations)HUNK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HUNK (select a term)
intoGenHUNK
Cancer3DHUNK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606532   
Orphanet
MedgenHUNK
Genetic Testing Registry HUNK
NextProtP57058 [Medical]
TSGene30811
GENETestsHUNK
Target ValidationHUNK
Huge Navigator HUNK [HugePedia]
snp3D : Map Gene to Disease30811
BioCentury BCIQHUNK
ClinGenHUNK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD30811
Chemical/Pharm GKB GenePA29563
Clinical trialHUNK
Miscellaneous
canSAR (ICR)HUNK (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHUNK
EVEXHUNK
GoPubMedHUNK
iHOPHUNK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:55:55 CEST 2017

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