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HYAL3 (hyaluronoglucosaminidase 3)

Identity

Alias_symbol (synonym)LUCA-3
LUCA14
Minna14
Other aliasHYAL-3
LUCA3
HGNC (Hugo) HYAL3
LocusID (NCBI) 8372
Atlas_Id 40905
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 50330259 and ends at 50336293 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
HYAL3 (3p21.31) / HYAL3 (3p21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HYAL3   5322
Cards
Entrez_Gene (NCBI)HYAL3  8372  hyaluronoglucosaminidase 3
AliasesHYAL-3; LUCA-3; LUCA3
GeneCards (Weizmann)HYAL3
Ensembl hg19 (Hinxton)ENSG00000186792 [Gene_View]  chr3:50330259-50336293 [Contig_View]  HYAL3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000186792 [Gene_View]  chr3:50330259-50336293 [Contig_View]  HYAL3 [Vega]
ICGC DataPortalENSG00000186792
TCGA cBioPortalHYAL3
AceView (NCBI)HYAL3
Genatlas (Paris)HYAL3
WikiGenes8372
SOURCE (Princeton)HYAL3
Genetics Home Reference (NIH)HYAL3
Genomic and cartography
GoldenPath hg19 (UCSC)HYAL3  -     chr3:50330259-50336293 -  3p21.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HYAL3  -     3p21.31   [Description]    (hg38-Dec_2013)
EnsemblHYAL3 - 3p21.31 [CytoView hg19]  HYAL3 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBIHYAL3 [Mapview hg19]  HYAL3 [Mapview hg38]
OMIM604038   
Gene and transcription
Genbank (Entrez)AF036035 AF040710 AF502909 AF502910 AF502911
RefSeq transcript (Entrez)NM_001200029 NM_001200030 NM_001200031 NM_001200032 NM_003549
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)HYAL3
Cluster EST : UnigeneHs.729310 [ NCBI ]
CGAP (NCI)Hs.729310
Alternative Splicing GalleryENSG00000186792
Gene ExpressionHYAL3 [ NCBI-GEO ]   HYAL3 [ EBI - ARRAY_EXPRESS ]   HYAL3 [ SEEK ]   HYAL3 [ MEM ]
Gene Expression Viewer (FireBrowse)HYAL3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8372
GTEX Portal (Tissue expression)HYAL3
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43820   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43820  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43820
Splice isoforms : SwissVarO43820
Catalytic activity : Enzyme3.2.1.35 [ Enzyme-Expasy ]   3.2.1.353.2.1.35 [ IntEnz-EBI ]   3.2.1.35 [ BRENDA ]   3.2.1.35 [ KEGG ]   
PhosPhoSitePlusO43820
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)   
Domains : Interpro (EBI)Aldolase_TIM    EGF-like_dom    Glycoside_hydrolase_SF    Hyaluronidase    Hyaluronidase-3   
Domain families : Pfam (Sanger)Glyco_hydro_56 (PF01630)   
Domain families : Pfam (NCBI)pfam01630   
Domain families : Smart (EMBL)EGF (SM00181)  
Conserved Domain (NCBI)HYAL3
DMDM Disease mutations8372
Blocks (Seattle)HYAL3
SuperfamilyO43820
Human Protein AtlasENSG00000186792
Peptide AtlasO43820
IPIIPI00168846   IPI00784874   IPI00785185   IPI00030202   IPI00924571   
Protein Interaction databases
DIP (DOE-UCLA)O43820
IntAct (EBI)O43820
FunCoupENSG00000186792
BioGRIDHYAL3
STRING (EMBL)HYAL3
ZODIACHYAL3
Ontologies - Pathways
QuickGOO43820
Ontology : AmiGOvirus receptor activity  hyalurononglucosaminidase activity  hyalurononglucosaminidase activity  protein binding  extracellular region  lysosome  carbohydrate metabolic process  inflammatory response  response to virus  hyaluronan catabolic process  cytoplasmic vesicle  hyaluronoglucuronidase activity  response to antibiotic  cartilage development  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to UV-B  
Ontology : EGO-EBIvirus receptor activity  hyalurononglucosaminidase activity  hyalurononglucosaminidase activity  protein binding  extracellular region  lysosome  carbohydrate metabolic process  inflammatory response  response to virus  hyaluronan catabolic process  cytoplasmic vesicle  hyaluronoglucuronidase activity  response to antibiotic  cartilage development  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to UV-B  
Pathways : KEGGGlycosaminoglycan degradation   
NDEx NetworkHYAL3
Atlas of Cancer Signalling NetworkHYAL3
Wikipedia pathwaysHYAL3
Orthology - Evolution
OrthoDB8372
GeneTree (enSembl)ENSG00000186792
Phylogenetic Trees/Animal Genes : TreeFamHYAL3
HOVERGENO43820
HOGENOMO43820
Homologs : HomoloGeneHYAL3
Homology/Alignments : Family Browser (UCSC)HYAL3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHYAL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HYAL3
dbVarHYAL3
ClinVarHYAL3
1000_GenomesHYAL3 
Exome Variant ServerHYAL3
ExAC (Exome Aggregation Consortium)HYAL3 (select the gene name)
Genetic variants : HAPMAP8372
Genomic Variants (DGV)HYAL3 [DGVbeta]
DECIPHER (Syndromes)3:50330259-50336293  ENSG00000186792
CONAN: Copy Number AnalysisHYAL3 
Mutations
ICGC Data PortalHYAL3 
TCGA Data PortalHYAL3 
Broad Tumor PortalHYAL3
OASIS PortalHYAL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHYAL3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHYAL3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HYAL3
DgiDB (Drug Gene Interaction Database)HYAL3
DoCM (Curated mutations)HYAL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HYAL3 (select a term)
intoGenHYAL3
Cancer3DHYAL3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604038   
Orphanet
MedgenHYAL3
Genetic Testing Registry HYAL3
NextProtO43820 [Medical]
TSGene8372
GENETestsHYAL3
Huge Navigator HYAL3 [HugePedia]
snp3D : Map Gene to Disease8372
BioCentury BCIQHYAL3
ClinGenHYAL3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8372
Chemical/Pharm GKB GenePA29573
Clinical trialHYAL3
Miscellaneous
canSAR (ICR)HYAL3 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHYAL3
EVEXHYAL3
GoPubMedHYAL3
iHOPHYAL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:10:03 CET 2017

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