HYAL3 (hyaluronidase 3)

2003-06-01  

Identity

HGNC
HYAL3
LOCATION
3p21.31
LOCUSID
8372
ALIAS
HYAL-3,LUCA-3,LUCA3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8372
MIM: 604038
HGNC: 5322
Ensembl: ENSG00000186792

Variants:

dbSNP: 8372
ClinVar: 8372
TCGA: ENSG00000186792
COSMIC: HYAL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186792ENST00000336307O43820
ENSG00000186792ENST00000336307A0A024R2Y7
ENSG00000186792ENST00000359051O43820
ENSG00000186792ENST00000415204O43820
ENSG00000186792ENST00000435141C9JB51
ENSG00000186792ENST00000450982O43820
ENSG00000186792ENST00000513170O43820
ENSG00000186792ENST00000621157O43820
ENSG00000186792ENST00000621157A0A024R2Y7

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycosaminoglycan degradationKEGGko00531
Glycosaminoglycan degradationKEGGhsa00531
Metabolic pathwaysKEGGhsa01100
Dermatan sulfate degradationKEGGhsa_M00076
Chondroitin sulfate degradationKEGGhsa_M00077
Dermatan sulfate degradationKEGGM00076
Chondroitin sulfate degradationKEGGM00077
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Hyaluronan metabolismREACTOMER-HSA-2142845
Hyaluronan uptake and degradationREACTOMER-HSA-2160916
Chondroitin sulfate/dermatan sulfate metabolismREACTOMER-HSA-1793185
CS/DS degradationREACTOMER-HSA-2024101

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
120847182002Regulation of hyaluronidase activity by alternative mRNA splicing.16
126846322003Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines.12
208495972010Involvement of hyaluronidases in colorectal cancer.11
119298602002Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3.7
205860962010Acidic hyaluronidase activity is present in mouse sperm and is reduced in the absence of SPAM1: evidence for a role for hyaluronidase 3 in mouse and human sperm.5
251380662014Hyalurosome gene regulation and dose-dependent restoration of skin atrophy by retinaldehyde and defined-size hyaluronate fragments in dermatoporosis.3
208494452011Nodular basal cell carcinoma is associated with increased hyaluronan homeostasis.2
235490092013Analysis of HYAL3 gene mutations in Chinese lung squamous cell carcinoma patients.2
229603322012Genetic association and gene-gene interaction of HAS2, HABP1 and HYAL3 implicate hyaluronan metabolic genes in glaucomatous neurodegeneration.1

Citation

Dessen P

HYAL3 (hyaluronidase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40905/hyal3