HYAL4 (hyaluronidase 4)

2014-11-01  

Identity

HGNC
HYAL4
LOCATION
7q31.32
LOCUSID
23553
ALIAS
CSHY,HYAL-4

Other Information

Locus ID:

NCBI: 23553
MIM: 604510
HGNC: 5323
Ensembl: ENSG00000106302

Variants:

dbSNP: 23553
ClinVar: 23553
TCGA: ENSG00000106302
COSMIC: HYAL4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106302ENST00000223026Q2M3T9
ENSG00000106302ENST00000476325Q2M3T9
ENSG00000106302ENST00000483878F8WDH9
ENSG00000106302ENST00000488323C9J6F9
ENSG00000106302ENST00000489978C9JU18

Expression (GTEx)

0
1
2
3
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycosaminoglycan degradationKEGGko00531
Glycosaminoglycan degradationKEGGhsa00531
Metabolic pathwaysKEGGhsa01100
Dermatan sulfate degradationKEGGhsa_M00076
Chondroitin sulfate degradationKEGGhsa_M00077
Dermatan sulfate degradationKEGGM00076
Chondroitin sulfate degradationKEGGM00077

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
198898812010Identification of human hyaluronidase-4 as a novel chondroitin sulfate hydrolase that preferentially cleaves the galactosaminidic linkage in the trisulfated tetrasaccharide sequence.31
230869292012Identification of amino acid residues required for the substrate specificity of human and mouse chondroitin sulfate hydrolase (conventional hyaluronidase-4).8

Citation

Dessen P

HYAL4 (hyaluronidase 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64478/hyal4