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HYOU1 (hypoxia up-regulated 1)

Identity

Alias_symbol (synonym)ORP150
HSP12A
Grp170
Other aliasGRP-170
ORP-150
HGNC (Hugo) HYOU1
LocusID (NCBI) 10525
Atlas_Id 40907
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 118914896 and ends at 118927957 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
COLCA2 (11q23.1) / HYOU1 (11q23.3)HMGA1 (6p21.31) / HYOU1 (11q23.3)HYOU1 (11q23.3) / COLCA2 (11q23.1)
HYOU1 (11q23.3) / HMGA1 (6p21.31)HYOU1 (11q23.3) / HYOU1 (11q23.3)HYOU1 (11q23.3) / MTCH1 (6p21.2)
HYOU1 (11q23.3) / PSPH (7p11.2)HYOU1 (11q23.3) / TMEM59 (1p32.3)PEBP4 (8p21.3) / HYOU1 (11q23.3)
RRP15 (1q41) / HYOU1 (11q23.3)TRIM25 (17q22) / HYOU1 (11q23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)HYOU1   16931
Cards
Entrez_Gene (NCBI)HYOU1  10525  hypoxia up-regulated 1
AliasesGRP-170; Grp170; HSP12A; ORP-150; 
ORP150
GeneCards (Weizmann)HYOU1
Ensembl hg19 (Hinxton)ENSG00000149428 [Gene_View]  chr11:118914896-118927957 [Contig_View]  HYOU1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000149428 [Gene_View]  chr11:118914896-118927957 [Contig_View]  HYOU1 [Vega]
ICGC DataPortalENSG00000149428
TCGA cBioPortalHYOU1
AceView (NCBI)HYOU1
Genatlas (Paris)HYOU1
WikiGenes10525
SOURCE (Princeton)HYOU1
Genetics Home Reference (NIH)HYOU1
Genomic and cartography
GoldenPath hg19 (UCSC)HYOU1  -     chr11:118914896-118927957 -  11q23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)HYOU1  -     11q23.3   [Description]    (hg38-Dec_2013)
EnsemblHYOU1 - 11q23.3 [CytoView hg19]  HYOU1 - 11q23.3 [CytoView hg38]
Mapping of homologs : NCBIHYOU1 [Mapview hg19]  HYOU1 [Mapview hg38]
OMIM601746   
Gene and transcription
Genbank (Entrez)AA580314 AK127324 AK222756 AK294905 AK297260
RefSeq transcript (Entrez)NM_001130991 NM_006389
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_033899 NW_004929381 NW_009646203
Consensus coding sequences : CCDS (NCBI)HYOU1
Cluster EST : UnigeneHs.277704 [ NCBI ]
CGAP (NCI)Hs.277704
Alternative Splicing GalleryENSG00000149428
Gene ExpressionHYOU1 [ NCBI-GEO ]   HYOU1 [ EBI - ARRAY_EXPRESS ]   HYOU1 [ SEEK ]   HYOU1 [ MEM ]
Gene Expression Viewer (FireBrowse)HYOU1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10525
GTEX Portal (Tissue expression)HYOU1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y4L1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y4L1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y4L1
Splice isoforms : SwissVarQ9Y4L1
PhosPhoSitePlusQ9Y4L1
Domaine pattern : Prosite (Expaxy)HSP70_2 (PS00329)    HSP70_3 (PS01036)   
Domains : Interpro (EBI)Heat_shock_70_CS    HSP70_C    HSP70_peptide-bd    Hsp_70_fam   
Domain families : Pfam (Sanger)HSP70 (PF00012)   
Domain families : Pfam (NCBI)pfam00012   
Conserved Domain (NCBI)HYOU1
DMDM Disease mutations10525
Blocks (Seattle)HYOU1
SuperfamilyQ9Y4L1
Human Protein AtlasENSG00000149428
Peptide AtlasQ9Y4L1
HPRD03448
IPIIPI00000877   IPI01011324   IPI00922838   IPI00922127   IPI00977915   IPI00982087   IPI01010461   IPI00976071   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y4L1
IntAct (EBI)Q9Y4L1
FunCoupENSG00000149428
BioGRIDHYOU1
STRING (EMBL)HYOU1
ZODIACHYOU1
Ontologies - Pathways
QuickGOQ9Y4L1
Ontology : AmiGOresponse to ischemia  ATP binding  extracellular region  endoplasmic reticulum  endoplasmic reticulum lumen  smooth endoplasmic reticulum  focal adhesion  ER to Golgi vesicle-mediated transport  receptor-mediated endocytosis  membrane  endoplasmic reticulum chaperone complex  response to endoplasmic reticulum stress  IRE1-mediated unfolded protein response  chaperone binding  extracellular exosome  cellular response to hypoxia  cellular response to hypoxia  endocytic vesicle lumen  negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway  negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIresponse to ischemia  ATP binding  extracellular region  endoplasmic reticulum  endoplasmic reticulum lumen  smooth endoplasmic reticulum  focal adhesion  ER to Golgi vesicle-mediated transport  receptor-mediated endocytosis  membrane  endoplasmic reticulum chaperone complex  response to endoplasmic reticulum stress  IRE1-mediated unfolded protein response  chaperone binding  extracellular exosome  cellular response to hypoxia  cellular response to hypoxia  endocytic vesicle lumen  negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway  negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkHYOU1
Atlas of Cancer Signalling NetworkHYOU1
Wikipedia pathwaysHYOU1
Orthology - Evolution
OrthoDB10525
GeneTree (enSembl)ENSG00000149428
Phylogenetic Trees/Animal Genes : TreeFamHYOU1
HOVERGENQ9Y4L1
HOGENOMQ9Y4L1
Homologs : HomoloGeneHYOU1
Homology/Alignments : Family Browser (UCSC)HYOU1
Gene fusions - Rearrangements
Fusion : MitelmanHYOU1/COLCA2 [11q23.3/11q23.1]  
Fusion : MitelmanHYOU1/HMGA1 [11q23.3/6p21.31]  [t(6;11)(p21;q23)]  
Fusion Cancer (Beijing)C11orf93 [HYOU1]  -  11q23.3 [FUSC002681]  [FUSC002681]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHYOU1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HYOU1
dbVarHYOU1
ClinVarHYOU1
1000_GenomesHYOU1 
Exome Variant ServerHYOU1
ExAC (Exome Aggregation Consortium)HYOU1 (select the gene name)
Genetic variants : HAPMAP10525
Genomic Variants (DGV)HYOU1 [DGVbeta]
DECIPHER (Syndromes)11:118914896-118927957  ENSG00000149428
CONAN: Copy Number AnalysisHYOU1 
Mutations
ICGC Data PortalHYOU1 
TCGA Data PortalHYOU1 
Broad Tumor PortalHYOU1
OASIS PortalHYOU1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHYOU1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDHYOU1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HYOU1
DgiDB (Drug Gene Interaction Database)HYOU1
DoCM (Curated mutations)HYOU1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HYOU1 (select a term)
intoGenHYOU1
Cancer3DHYOU1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601746   
Orphanet
MedgenHYOU1
Genetic Testing Registry HYOU1
NextProtQ9Y4L1 [Medical]
TSGene10525
GENETestsHYOU1
Huge Navigator HYOU1 [HugePedia]
snp3D : Map Gene to Disease10525
BioCentury BCIQHYOU1
ClinGenHYOU1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10525
Chemical/Pharm GKB GenePA38427
Clinical trialHYOU1
Miscellaneous
canSAR (ICR)HYOU1 (select the gene name)
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHYOU1
EVEXHYOU1
GoPubMedHYOU1
iHOPHYOU1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:10:04 CET 2017

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