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IAPP (islet amyloid polypeptide)

Identity

Alias_symbol (synonym)AMYLIN
DAP
IAP
Other alias
HGNC (Hugo) IAPP
LocusID (NCBI) 3375
Atlas_Id 46516
Location 12p12.1  [Link to chromosome band 12p12]
Location_base_pair Starts at 21525802 and ends at 21532914 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ANO6 (12q12) / IAPP (12p12.1)ANO6 12q12 / IAPP 12p12.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IAPP   5329
Cards
Entrez_Gene (NCBI)IAPP  3375  islet amyloid polypeptide
AliasesDAP; IAP
GeneCards (Weizmann)IAPP
Ensembl hg19 (Hinxton)ENSG00000121351 [Gene_View]  chr12:21525802-21532914 [Contig_View]  IAPP [Vega]
Ensembl hg38 (Hinxton)ENSG00000121351 [Gene_View]  chr12:21525802-21532914 [Contig_View]  IAPP [Vega]
ICGC DataPortalENSG00000121351
TCGA cBioPortalIAPP
AceView (NCBI)IAPP
Genatlas (Paris)IAPP
WikiGenes3375
SOURCE (Princeton)IAPP
Genetics Home Reference (NIH)IAPP
Genomic and cartography
GoldenPath hg19 (UCSC)IAPP  -     chr12:21525802-21532914 +  12p12.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IAPP  -     12p12.1   [Description]    (hg38-Dec_2013)
EnsemblIAPP - 12p12.1 [CytoView hg19]  IAPP - 12p12.1 [CytoView hg38]
Mapping of homologs : NCBIIAPP [Mapview hg19]  IAPP [Mapview hg38]
OMIM147940   
Gene and transcription
Genbank (Entrez)BC111849 BQ548699 CK905016 DQ516082 J04422
RefSeq transcript (Entrez)NM_000415
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_009714 NW_004929383
Consensus coding sequences : CCDS (NCBI)IAPP
Cluster EST : UnigeneHs.46835 [ NCBI ]
CGAP (NCI)Hs.46835
Alternative Splicing GalleryENSG00000121351
Gene ExpressionIAPP [ NCBI-GEO ]   IAPP [ EBI - ARRAY_EXPRESS ]   IAPP [ SEEK ]   IAPP [ MEM ]
Gene Expression Viewer (FireBrowse)IAPP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3375
GTEX Portal (Tissue expression)IAPP
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10997   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10997  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10997
Splice isoforms : SwissVarP10997
PhosPhoSitePlusP10997
Domaine pattern : Prosite (Expaxy)CALCITONIN (PS00258)   
Domains : Interpro (EBI)Calcitonin-like    Calcitonin/adrenomedullin    Calcitonin_CS    Calcitonin_peptide-like    Pro-islet_amyloid_polypep   
Domain families : Pfam (Sanger)Calc_CGRP_IAPP (PF00214)   
Domain families : Pfam (NCBI)pfam00214   
Domain families : Smart (EMBL)CALCITONIN (SM00113)  
Conserved Domain (NCBI)IAPP
DMDM Disease mutations3375
Blocks (Seattle)IAPP
PDB (SRS)1KUW    2G48    2KB8    2L86    3DG1    3FPO    3FR1    3FTH    3FTK    3FTL    3FTR    3G7V    3G7W    3HGZ   
PDB (PDBSum)1KUW    2G48    2KB8    2L86    3DG1    3FPO    3FR1    3FTH    3FTK    3FTL    3FTR    3G7V    3G7W    3HGZ   
PDB (IMB)1KUW    2G48    2KB8    2L86    3DG1    3FPO    3FR1    3FTH    3FTK    3FTL    3FTR    3G7V    3G7W    3HGZ   
PDB (RSDB)1KUW    2G48    2KB8    2L86    3DG1    3FPO    3FR1    3FTH    3FTK    3FTL    3FTR    3G7V    3G7W    3HGZ   
Structural Biology KnowledgeBase1KUW    2G48    2KB8    2L86    3DG1    3FPO    3FR1    3FTH    3FTK    3FTL    3FTR    3G7V    3G7W    3HGZ   
SCOP (Structural Classification of Proteins)1KUW    2G48    2KB8    2L86    3DG1    3FPO    3FR1    3FTH    3FTK    3FTL    3FTR    3G7V    3G7W    3HGZ   
CATH (Classification of proteins structures)1KUW    2G48    2KB8    2L86    3DG1    3FPO    3FR1    3FTH    3FTK    3FTL    3FTR    3G7V    3G7W    3HGZ   
SuperfamilyP10997
Human Protein AtlasENSG00000121351
Peptide AtlasP10997
HPRD01005
IPIIPI00023679   IPI00795976   IPI01012213   IPI01010665   
Protein Interaction databases
DIP (DOE-UCLA)P10997
IntAct (EBI)P10997
FunCoupENSG00000121351
BioGRIDIAPP
STRING (EMBL)IAPP
ZODIACIAPP
Ontologies - Pathways
QuickGOP10997
Ontology : AmiGOreceptor binding  hormone activity  extracellular region  extracellular space  apoptotic process  signal transduction  cell-cell signaling  sensory perception of pain  eating behavior  identical protein binding  neuronal cell body  cellular protein metabolic process  negative regulation of cell differentiation  negative regulation of bone resorption  
Ontology : EGO-EBIreceptor binding  hormone activity  extracellular region  extracellular space  apoptotic process  signal transduction  cell-cell signaling  sensory perception of pain  eating behavior  identical protein binding  neuronal cell body  cellular protein metabolic process  negative regulation of cell differentiation  negative regulation of bone resorption  
Pathways : KEGGMaturity onset diabetes of the young   
NDEx NetworkIAPP
Atlas of Cancer Signalling NetworkIAPP
Wikipedia pathwaysIAPP
Orthology - Evolution
OrthoDB3375
GeneTree (enSembl)ENSG00000121351
Phylogenetic Trees/Animal Genes : TreeFamIAPP
HOVERGENP10997
HOGENOMP10997
Homologs : HomoloGeneIAPP
Homology/Alignments : Family Browser (UCSC)IAPP
Gene fusions - Rearrangements
Fusion : MitelmanANO6/IAPP [12q12/12p12.1]  [t(12;12)(p12;q12)]  
Fusion: TCGAANO6 12q12 IAPP 12p12.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIAPP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IAPP
dbVarIAPP
ClinVarIAPP
1000_GenomesIAPP 
Exome Variant ServerIAPP
ExAC (Exome Aggregation Consortium)IAPP (select the gene name)
Genetic variants : HAPMAP3375
Genomic Variants (DGV)IAPP [DGVbeta]
DECIPHER (Syndromes)12:21525802-21532914  ENSG00000121351
CONAN: Copy Number AnalysisIAPP 
Mutations
ICGC Data PortalIAPP 
TCGA Data PortalIAPP 
Broad Tumor PortalIAPP
OASIS PortalIAPP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIAPP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIAPP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IAPP
DgiDB (Drug Gene Interaction Database)IAPP
DoCM (Curated mutations)IAPP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IAPP (select a term)
intoGenIAPP
Cancer3DIAPP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147940   
Orphanet
MedgenIAPP
Genetic Testing Registry IAPP
NextProtP10997 [Medical]
TSGene3375
GENETestsIAPP
Huge Navigator IAPP [HugePedia]
snp3D : Map Gene to Disease3375
BioCentury BCIQIAPP
ClinGenIAPP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3375
Chemical/Pharm GKB GenePA29579
Clinical trialIAPP
Miscellaneous
canSAR (ICR)IAPP (select the gene name)
Probes
Litterature
PubMed236 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIAPP
EVEXIAPP
GoPubMedIAPP
iHOPIAPP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:10:04 CET 2017

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