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IARS (isoleucyl-tRNA synthetase)

Identity

Alias_symbol (synonym)ILRS
IARS1
Other aliasILERS
IRS
PRO0785
HGNC (Hugo) IARS
LocusID (NCBI) 3376
Atlas_Id 64485
Location 9q22.31  [Link to chromosome band 9q22]
Location_base_pair Starts at 94972490 and ends at 95056038 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
IARS (9q22.31) / IARS (9q22.31)IARS (9q22.31) / IFT46 (11q23.3)IARS (9q22.31) / RAD54L2 (3p21.2)
IARS (9q22.31) / SLC10A7 (4q31.22)IARS (9q22.31) / TTR (18q12.1)LOC338799 () / IARS (9q22.31)
RGPD2 (2p11.2) / IARS (9q22.31)RPS20 (8q12.1) / IARS (9q22.31)UACA (15q23) / IARS (9q22.31)
ZMYND8 (20q13.12) / IARS (9q22.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IARS   5330
Cards
Entrez_Gene (NCBI)IARS  3376  isoleucyl-tRNA synthetase
AliasesIARS1; ILERS; ILRS; IRS; 
PRO0785
GeneCards (Weizmann)IARS
Ensembl hg19 (Hinxton)ENSG00000196305 [Gene_View]  chr9:94972490-95056038 [Contig_View]  IARS [Vega]
Ensembl hg38 (Hinxton)ENSG00000196305 [Gene_View]  chr9:94972490-95056038 [Contig_View]  IARS [Vega]
ICGC DataPortalENSG00000196305
TCGA cBioPortalIARS
AceView (NCBI)IARS
Genatlas (Paris)IARS
WikiGenes3376
SOURCE (Princeton)IARS
Genetics Home Reference (NIH)IARS
Genomic and cartography
GoldenPath hg19 (UCSC)IARS  -     chr9:94972490-95056038 -  9q22.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IARS  -     9q22.31   [Description]    (hg38-Dec_2013)
EnsemblIARS - 9q22.31 [CytoView hg19]  IARS - 9q22.31 [CytoView hg38]
Mapping of homologs : NCBIIARS [Mapview hg19]  IARS [Mapview hg38]
OMIM600709   
Gene and transcription
Genbank (Entrez)AA731323 AB209234 AK057920 AK123909 AK127087
RefSeq transcript (Entrez)NM_002161 NM_013417
RefSeq genomic (Entrez)NC_000009 NC_018920 NT_008470 NW_004929366
Consensus coding sequences : CCDS (NCBI)IARS
Cluster EST : UnigeneHs.445403 [ NCBI ]
CGAP (NCI)Hs.445403
Alternative Splicing GalleryENSG00000196305
Gene ExpressionIARS [ NCBI-GEO ]   IARS [ EBI - ARRAY_EXPRESS ]   IARS [ SEEK ]   IARS [ MEM ]
Gene Expression Viewer (FireBrowse)IARS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3376
GTEX Portal (Tissue expression)IARS
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41252   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP41252  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41252
Splice isoforms : SwissVarP41252
Catalytic activity : Enzyme6.1.1.5 [ Enzyme-Expasy ]   6.1.1.56.1.1.5 [ IntEnz-EBI ]   6.1.1.5 [ BRENDA ]   6.1.1.5 [ KEGG ]   
PhosPhoSitePlusP41252
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_I (PS00178)   
Domains : Interpro (EBI)aa-tRNA-synth_I_CS    aa-tRNA-synth_Ia    Ile-tRNA-ligase    Ile-tRNA-ligase_type2    M/V/L/I-tRNA-synth_anticd-bd    Rossmann-like_a/b/a_fold    tRNAsynth_1a_anticodon-bd    Val/Leu/Ile-tRNA-synth_edit   
Domain families : Pfam (Sanger)Anticodon_1 (PF08264)    tRNA-synt_1 (PF00133)   
Domain families : Pfam (NCBI)pfam08264    pfam00133   
Conserved Domain (NCBI)IARS
DMDM Disease mutations3376
Blocks (Seattle)IARS
SuperfamilyP41252
Human Protein AtlasENSG00000196305
Peptide AtlasP41252
HPRD02832
IPIIPI00644127   IPI00978891   IPI00514385   IPI00910980   IPI00982482   IPI00514082   IPI00644198   IPI00644832   
Protein Interaction databases
DIP (DOE-UCLA)P41252
IntAct (EBI)P41252
FunCoupENSG00000196305
BioGRIDIARS
STRING (EMBL)IARS
ZODIACIARS
Ontologies - Pathways
QuickGOP41252
Ontology : AmiGOosteoblast differentiation  aminoacyl-tRNA editing activity  isoleucine-tRNA ligase activity  isoleucine-tRNA ligase activity  protein binding  ATP binding  nucleoplasm  cytoplasm  cytosol  cytosol  tRNA aminoacylation for protein translation  isoleucyl-tRNA aminoacylation  regulation of translational fidelity  gene expression  membrane  GTPase binding  extracellular exosome  
Ontology : EGO-EBIosteoblast differentiation  aminoacyl-tRNA editing activity  isoleucine-tRNA ligase activity  isoleucine-tRNA ligase activity  protein binding  ATP binding  nucleoplasm  cytoplasm  cytosol  cytosol  tRNA aminoacylation for protein translation  isoleucyl-tRNA aminoacylation  regulation of translational fidelity  gene expression  membrane  GTPase binding  extracellular exosome  
Pathways : KEGGAminoacyl-tRNA biosynthesis   
NDEx NetworkIARS
Atlas of Cancer Signalling NetworkIARS
Wikipedia pathwaysIARS
Orthology - Evolution
OrthoDB3376
GeneTree (enSembl)ENSG00000196305
Phylogenetic Trees/Animal Genes : TreeFamIARS
HOVERGENP41252
HOGENOMP41252
Homologs : HomoloGeneIARS
Homology/Alignments : Family Browser (UCSC)IARS
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIARS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IARS
dbVarIARS
ClinVarIARS
1000_GenomesIARS 
Exome Variant ServerIARS
ExAC (Exome Aggregation Consortium)IARS (select the gene name)
Genetic variants : HAPMAP3376
Genomic Variants (DGV)IARS [DGVbeta]
DECIPHER (Syndromes)9:94972490-95056038  ENSG00000196305
CONAN: Copy Number AnalysisIARS 
Mutations
ICGC Data PortalIARS 
TCGA Data PortalIARS 
Broad Tumor PortalIARS
OASIS PortalIARS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIARS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIARS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IARS
DgiDB (Drug Gene Interaction Database)IARS
DoCM (Curated mutations)IARS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IARS (select a term)
intoGenIARS
Cancer3DIARS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600709   
Orphanet
MedgenIARS
Genetic Testing Registry IARS
NextProtP41252 [Medical]
TSGene3376
GENETestsIARS
Huge Navigator IARS [HugePedia]
snp3D : Map Gene to Disease3376
BioCentury BCIQIARS
ClinGenIARS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3376
Chemical/Pharm GKB GenePA29580
Clinical trialIARS
Miscellaneous
canSAR (ICR)IARS (select the gene name)
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIARS
EVEXIARS
GoPubMedIARS
iHOPIARS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:08:26 CET 2017

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