Atlas of Genetics and Cytogenetics in Oncology and Haematology


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IARS2 (isoleucyl-tRNA synthetase 2, mitochondrial)

Identity

Other aliasCAGSSS
ILERS
HGNC (Hugo) IARS2
LocusID (NCBI) 55699
Atlas_Id 56687
Location 1q41  [Link to chromosome band 1q41]
Location_base_pair Starts at 220094113 and ends at 220148041 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IARS2   29685
Cards
Entrez_Gene (NCBI)IARS2  55699  isoleucyl-tRNA synthetase 2, mitochondrial
AliasesCAGSSS; ILERS
GeneCards (Weizmann)IARS2
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr1:220094113-220148041 [Contig_View]  IARS2 [Vega]
TCGA cBioPortalIARS2
AceView (NCBI)IARS2
Genatlas (Paris)IARS2
WikiGenes55699
SOURCE (Princeton)IARS2
Genetics Home Reference (NIH)IARS2
Genomic and cartography
GoldenPath hg38 (UCSC)IARS2  -     chr1:220094113-220148041 +  1q41   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IARS2  -     1q41   [Description]    (hg19-Feb_2009)
EnsemblIARS2 - 1q41 [CytoView hg19]  IARS2 - 1q41 [CytoView hg38]
Mapping of homologs : NCBIIARS2 [Mapview hg19]  IARS2 [Mapview hg38]
OMIM612801   616007   
Gene and transcription
Genbank (Entrez)AK001188 AK001726 AK022665 AK291432 AY267462
RefSeq transcript (Entrez)NM_018060
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IARS2
Cluster EST : UnigeneHs.262823 [ NCBI ]
CGAP (NCI)Hs.262823
Gene ExpressionIARS2 [ NCBI-GEO ]   IARS2 [ EBI - ARRAY_EXPRESS ]   IARS2 [ SEEK ]   IARS2 [ MEM ]
Gene Expression Viewer (FireBrowse)IARS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55699
GTEX Portal (Tissue expression)IARS2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NSE4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NSE4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NSE4
Splice isoforms : SwissVarQ9NSE4
Catalytic activity : Enzyme6.1.1.5 [ Enzyme-Expasy ]   6.1.1.56.1.1.5 [ IntEnz-EBI ]   6.1.1.5 [ BRENDA ]   6.1.1.5 [ KEGG ]   
PhosPhoSitePlusQ9NSE4
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_I (PS00178)   
Domains : Interpro (EBI)aa-tRNA-synth_I_CS    aa-tRNA-synth_Ia    Anticodon_Ile_BEm    Ile-tRNA-ligase    Ile-tRNA-ligase_type1    M/V/L/I-tRNA-synth_anticd-bd    Rossmann-like_a/b/a_fold    tRNAsynth_Ia_anticodon-bd    Val/Leu/Ile-tRNA-synth_edit    Znf_FPG/IleRS   
Domain families : Pfam (Sanger)Anticodon_1 (PF08264)    tRNA-synt_1 (PF00133)    zf-FPG_IleRS (PF06827)   
Domain families : Pfam (NCBI)pfam08264    pfam00133    pfam06827   
Conserved Domain (NCBI)IARS2
DMDM Disease mutations55699
Blocks (Seattle)IARS2
SuperfamilyQ9NSE4
Peptide AtlasQ9NSE4
IPIIPI00017283   
Protein Interaction databases
DIP (DOE-UCLA)Q9NSE4
IntAct (EBI)Q9NSE4
BioGRIDIARS2
STRING (EMBL)IARS2
ZODIACIARS2
Ontologies - Pathways
QuickGOQ9NSE4
Ontology : AmiGOtRNA binding  aminoacyl-tRNA editing activity  isoleucine-tRNA ligase activity  ATP binding  mitochondrion  mitochondrial matrix  cytosol  tRNA aminoacylation for protein translation  isoleucyl-tRNA aminoacylation  regulation of translational fidelity  
Ontology : EGO-EBItRNA binding  aminoacyl-tRNA editing activity  isoleucine-tRNA ligase activity  ATP binding  mitochondrion  mitochondrial matrix  cytosol  tRNA aminoacylation for protein translation  isoleucyl-tRNA aminoacylation  regulation of translational fidelity  
Pathways : KEGGAminoacyl-tRNA biosynthesis   
NDEx NetworkIARS2
Atlas of Cancer Signalling NetworkIARS2
Wikipedia pathwaysIARS2
Orthology - Evolution
OrthoDB55699
Phylogenetic Trees/Animal Genes : TreeFamIARS2
HOVERGENQ9NSE4
HOGENOMQ9NSE4
Homologs : HomoloGeneIARS2
Homology/Alignments : Family Browser (UCSC)IARS2
Gene fusions - Rearrangements
Tumor Fusion PortalIARS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIARS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IARS2
dbVarIARS2
ClinVarIARS2
1000_GenomesIARS2 
Exome Variant ServerIARS2
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP55699
Genomic Variants (DGV)IARS2 [DGVbeta]
DECIPHERIARS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIARS2 
Mutations
ICGC Data PortalIARS2 
TCGA Data PortalIARS2 
Broad Tumor PortalIARS2
OASIS PortalIARS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIARS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIARS2
BioMutasearch IARS2
DgiDB (Drug Gene Interaction Database)IARS2
DoCM (Curated mutations)IARS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IARS2 (select a term)
intoGenIARS2
Cancer3DIARS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612801    616007   
Orphanet
DisGeNETIARS2
MedgenIARS2
Genetic Testing Registry IARS2
NextProtQ9NSE4 [Medical]
TSGene55699
GENETestsIARS2
Target ValidationIARS2
Huge Navigator IARS2 [HugePedia]
snp3D : Map Gene to Disease55699
BioCentury BCIQIARS2
ClinGenIARS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55699
Chemical/Pharm GKB GenePA142671670
Clinical trialIARS2
Miscellaneous
canSAR (ICR)IARS2 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIARS2
EVEXIARS2
GoPubMedIARS2
iHOPIARS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:17:08 CET 2017

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