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ICA1 (islet cell autoantigen 1)

Identity

Alias (NCBI)ICA69
ICAp69
HGNC (Hugo) ICA1
HGNC Alias symbICAp69
ICA69
HGNC Previous nameislet cell autoantigen 1 (69kD)
 islet cell autoantigen 1, 69kDa
LocusID (NCBI) 3382
Atlas_Id 64489
Location 7p21.3  [Link to chromosome band 7p21]
Location_base_pair Starts at 8113185 and ends at 8262167 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ICA1 (7p21.3) / ICA1 (7p21.3)SUN1 (7p22.3) / ICA1 (7p21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ICA1   5343
Cards
Entrez_Gene (NCBI)ICA1    islet cell autoantigen 1
AliasesICA69; ICAp69
GeneCards (Weizmann)ICA1
Ensembl hg19 (Hinxton)ENSG00000003147 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000003147 [Gene_View]  ENSG00000003147 [Sequence]  chr7:8113185-8262167 [Contig_View]  ICA1 [Vega]
ICGC DataPortalENSG00000003147
TCGA cBioPortalICA1
AceView (NCBI)ICA1
Genatlas (Paris)ICA1
SOURCE (Princeton)ICA1
Genetics Home Reference (NIH)ICA1
Genomic and cartography
GoldenPath hg38 (UCSC)ICA1  -     chr7:8113185-8262167 -  7p21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ICA1  -     7p21.3   [Description]    (hg19-Feb_2009)
GoldenPathICA1 - 7p21.3 [CytoView hg19]  ICA1 - 7p21.3 [CytoView hg38]
ImmunoBaseENSG00000003147
Genome Data Viewer NCBIICA1 [Mapview hg19]  
OMIM147625   
Gene and transcription
Genbank (Entrez)AA581444 AI346099 AK292106 BC005922 BC008640
RefSeq transcript (Entrez)NM_001136020 NM_001276478 NM_001350819 NM_001350820 NM_001350821 NM_001350823 NM_001350824 NM_001350825 NM_001350826 NM_001350827 NM_001350828 NM_001350829 NM_001350830 NM_001350831 NM_001350832 NM_001350833 NM_001350834 NM_001350835 NM_001350836 NM_001350837 NM_001350838 NM_004968 NM_022307 NM_022308
Consensus coding sequences : CCDS (NCBI)ICA1
Gene ExpressionICA1 [ NCBI-GEO ]   ICA1 [ EBI - ARRAY_EXPRESS ]   ICA1 [ SEEK ]   ICA1 [ MEM ]
Gene Expression Viewer (FireBrowse)ICA1 [ Firebrowse - Broad ]
GenevisibleExpression of ICA1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3382
GTEX Portal (Tissue expression)ICA1
Human Protein AtlasENSG00000003147-ICA1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ05084   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ05084  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ05084
PhosPhoSitePlusQ05084
Domaine pattern : Prosite (Expaxy)AH (PS50870)   
Domains : Interpro (EBI)AH/BAR_dom_sf    AH_dom    ICA1    Islet_autoAg_Ica1/Ica1-like    Islet_autoAg_Ica1_C   
Domain families : Pfam (Sanger)Arfaptin (PF06456)    ICA69 (PF04629)   
Domain families : Pfam (NCBI)pfam06456    pfam04629   
Domain families : Smart (EMBL)Arfaptin (SM01015)  ICA69 (SM01237)  
Conserved Domain (NCBI)ICA1
SuperfamilyQ05084
AlphaFold pdb e-kbQ05084   
Human Protein Atlas [tissue]ENSG00000003147-ICA1 [tissue]
HPRD00971
Protein Interaction databases
DIP (DOE-UCLA)Q05084
IntAct (EBI)Q05084
BioGRIDICA1
STRING (EMBL)ICA1
ZODIACICA1
Ontologies - Pathways
QuickGOQ05084
Ontology : AmiGOGolgi membrane  protein binding  cytoplasm  Golgi apparatus  cytosol  cytosol  neurotransmitter transport  protein domain specific binding  secretory granule membrane  synaptic vesicle membrane  intracellular membrane-bounded organelle  regulation of insulin secretion  regulation of transport  membrane curvature sensor activity  
Ontology : EGO-EBIGolgi membrane  protein binding  cytoplasm  Golgi apparatus  cytosol  cytosol  neurotransmitter transport  protein domain specific binding  secretory granule membrane  synaptic vesicle membrane  intracellular membrane-bounded organelle  regulation of insulin secretion  regulation of transport  membrane curvature sensor activity  
Pathways : KEGGType I diabetes mellitus   
NDEx NetworkICA1
Atlas of Cancer Signalling NetworkICA1
Wikipedia pathwaysICA1
Orthology - Evolution
OrthoDB3382
GeneTree (enSembl)ENSG00000003147
Phylogenetic Trees/Animal Genes : TreeFamICA1
Homologs : HomoloGeneICA1
Homology/Alignments : Family Browser (UCSC)ICA1
Gene fusions - Rearrangements
Fusion : QuiverICA1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerICA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ICA1
dbVarICA1
ClinVarICA1
MonarchICA1
1000_GenomesICA1 
Exome Variant ServerICA1
GNOMAD BrowserENSG00000003147
Varsome BrowserICA1
ACMGICA1 variants
VarityQ05084
Genomic Variants (DGV)ICA1 [DGVbeta]
DECIPHERICA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisICA1 
Mutations
ICGC Data PortalICA1 
TCGA Data PortalICA1 
Broad Tumor PortalICA1
OASIS PortalICA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICICA1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DICA1
Mutations and Diseases : HGMDICA1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaICA1
DgiDB (Drug Gene Interaction Database)ICA1
DoCM (Curated mutations)ICA1
CIViC (Clinical Interpretations of Variants in Cancer)ICA1
Cancer3DICA1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147625   
Orphanet
DisGeNETICA1
MedgenICA1
Genetic Testing Registry ICA1
NextProtQ05084 [Medical]
GENETestsICA1
Target ValidationICA1
Huge Navigator ICA1 [HugePedia]
ClinGenICA1
Clinical trials, drugs, therapy
MyCancerGenomeICA1
Protein Interactions : CTDICA1
Pharm GKB GenePA29591
PharosQ05084
Clinical trialICA1
Miscellaneous
canSAR (ICR)ICA1
HarmonizomeICA1
DataMed IndexICA1
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXICA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:53:24 CEST 2021

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