Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ICK (intestinal cell kinase)

Identity

Alias_namesintestinal cell (MAK-like) kinase
Alias_symbol (synonym)MRK
LCK2
KIAA0936
MGC46090
Other aliasECO
EJM10
HGNC (Hugo) ICK
LocusID (NCBI) 22858
Atlas_Id 43313
Location 6p12.1  [Link to chromosome band 6p12]
Location_base_pair Starts at 53001300 and ends at 53061802 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ICK (6p12.2) / ICK (6p12.2)TRMT11 (6q22.32) / ICK (6p12.2)TRMT11 6q22.32 / ICK 6p12.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(p12;q22) TRMT11/ICK


External links

Nomenclature
HGNC (Hugo)ICK   21219
Cards
Entrez_Gene (NCBI)ICK  22858  intestinal cell kinase
AliasesECO; EJM10; LCK2; MRK
GeneCards (Weizmann)ICK
Ensembl hg19 (Hinxton)ENSG00000112144 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112144 [Gene_View]  ENSG00000112144 [Sequence]  chr6:53001300-53061802 [Contig_View]  ICK [Vega]
ICGC DataPortalENSG00000112144
TCGA cBioPortalICK
AceView (NCBI)ICK
Genatlas (Paris)ICK
WikiGenes22858
SOURCE (Princeton)ICK
Genetics Home Reference (NIH)ICK
Genomic and cartography
GoldenPath hg38 (UCSC)ICK  -     chr6:53001300-53061802 -  6p12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ICK  -     6p12.1   [Description]    (hg19-Feb_2009)
EnsemblICK - 6p12.1 [CytoView hg19]  ICK - 6p12.1 [CytoView hg38]
Mapping of homologs : NCBIICK [Mapview hg19]  ICK [Mapview hg38]
OMIM612325   612651   617924   
Gene and transcription
Genbank (Entrez)AB023153 AF152469 AF225919 AI699136 AJ420557
RefSeq transcript (Entrez)NM_014920 NM_016513
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ICK
Cluster EST : UnigeneHs.417022 [ NCBI ]
CGAP (NCI)Hs.417022
Alternative Splicing GalleryENSG00000112144
Gene ExpressionICK [ NCBI-GEO ]   ICK [ EBI - ARRAY_EXPRESS ]   ICK [ SEEK ]   ICK [ MEM ]
Gene Expression Viewer (FireBrowse)ICK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22858
GTEX Portal (Tissue expression)ICK
Human Protein AtlasENSG00000112144-ICK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UPZ9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UPZ9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UPZ9
Splice isoforms : SwissVarQ9UPZ9
PhosPhoSitePlusQ9UPZ9
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)ICK
DMDM Disease mutations22858
Blocks (Seattle)ICK
SuperfamilyQ9UPZ9
Human Protein Atlas [tissue]ENSG00000112144-ICK [tissue]
Peptide AtlasQ9UPZ9
HPRD09996
IPIIPI00414132   IPI00217776   
Protein Interaction databases
DIP (DOE-UCLA)Q9UPZ9
IntAct (EBI)Q9UPZ9
FunCoupENSG00000112144
BioGRIDICK
STRING (EMBL)ICK
ZODIACICK
Ontologies - Pathways
QuickGOQ9UPZ9
Ontology : AmiGOmagnesium ion binding  fibrillar center  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleus  cytoplasm  cytosol  cilium  cilium  protein phosphorylation  signal transduction  multicellular organism development  regulation of gene expression  intracellular signal transduction  intracellular signal transduction  intraciliary anterograde transport  intraciliary retrograde transport  ciliary basal body  intraciliary transport  intraciliary transport  cilium assembly  cilium assembly  ciliary tip  ciliary base  
Ontology : EGO-EBImagnesium ion binding  fibrillar center  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleus  cytoplasm  cytosol  cilium  cilium  protein phosphorylation  signal transduction  multicellular organism development  regulation of gene expression  intracellular signal transduction  intracellular signal transduction  intraciliary anterograde transport  intraciliary retrograde transport  ciliary basal body  intraciliary transport  intraciliary transport  cilium assembly  cilium assembly  ciliary tip  ciliary base  
NDEx NetworkICK
Atlas of Cancer Signalling NetworkICK
Wikipedia pathwaysICK
Orthology - Evolution
OrthoDB22858
GeneTree (enSembl)ENSG00000112144
Phylogenetic Trees/Animal Genes : TreeFamICK
HOVERGENQ9UPZ9
HOGENOMQ9UPZ9
Homologs : HomoloGeneICK
Homology/Alignments : Family Browser (UCSC)ICK
Gene fusions - Rearrangements
Fusion : MitelmanTRMT11/ICK [6q22.32/6p12.2]  [t(6;6)(p12;q22)]  
Fusion PortalTRMT11 6q22.32 ICK 6p12.2 BRCA
Fusion : QuiverICK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerICK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ICK
dbVarICK
ClinVarICK
1000_GenomesICK 
Exome Variant ServerICK
ExAC (Exome Aggregation Consortium)ENSG00000112144
GNOMAD BrowserENSG00000112144
Varsome BrowserICK
Genetic variants : HAPMAP22858
Genomic Variants (DGV)ICK [DGVbeta]
DECIPHERICK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisICK 
Mutations
ICGC Data PortalICK 
TCGA Data PortalICK 
Broad Tumor PortalICK
OASIS PortalICK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICICK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDICK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ICK
DgiDB (Drug Gene Interaction Database)ICK
DoCM (Curated mutations)ICK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ICK (select a term)
intoGenICK
Cancer3DICK(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612325    612651    617924   
Orphanet18403   
DisGeNETICK
MedgenICK
Genetic Testing Registry ICK
NextProtQ9UPZ9 [Medical]
TSGene22858
GENETestsICK
Target ValidationICK
Huge Navigator ICK [HugePedia]
snp3D : Map Gene to Disease22858
BioCentury BCIQICK
ClinGenICK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22858
Chemical/Pharm GKB GenePA134894544
Clinical trialICK
Miscellaneous
canSAR (ICR)ICK (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineICK
EVEXICK
GoPubMedICK
iHOPICK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:12:29 CET 2018

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