Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ICMT (isoprenylcysteine carboxyl methyltransferase)

Identity

Alias_symbol (synonym)PCCMT
HSTE14
PPMT
Other aliasMST098
MSTP098
PCMT
HGNC (Hugo) ICMT
LocusID (NCBI) 23463
Atlas_Id 53820
Location 1p36.31  [Link to chromosome band 1p36]
Location_base_pair Starts at 6221193 and ends at 6235984 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C16orf74 (16q24.1) / ICMT (1p36.31)ICMT (1p36.31) / GPR153 (1p36.31)ICMT 1p36.31 / GPR153 1p36.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  ICMT/GPR153 (1p36)


External links

Nomenclature
HGNC (Hugo)ICMT   5350
Cards
Entrez_Gene (NCBI)ICMT  23463  isoprenylcysteine carboxyl methyltransferase
AliasesHSTE14; MST098; MSTP098; PCCMT; 
PCMT; PPMT
GeneCards (Weizmann)ICMT
Ensembl hg19 (Hinxton)ENSG00000116237 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116237 [Gene_View]  ENSG00000116237 [Sequence]  chr1:6221193-6235984 [Contig_View]  ICMT [Vega]
ICGC DataPortalENSG00000116237
TCGA cBioPortalICMT
AceView (NCBI)ICMT
Genatlas (Paris)ICMT
WikiGenes23463
SOURCE (Princeton)ICMT
Genetics Home Reference (NIH)ICMT
Genomic and cartography
GoldenPath hg38 (UCSC)ICMT  -     chr1:6221193-6235984 -  1p36.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ICMT  -     1p36.31   [Description]    (hg19-Feb_2009)
EnsemblICMT - 1p36.31 [CytoView hg19]  ICMT - 1p36.31 [CytoView hg38]
Mapping of homologs : NCBIICMT [Mapview hg19]  ICMT [Mapview hg38]
OMIM605851   
Gene and transcription
Genbank (Entrez)AF064084 AF173157 AK092890 AL117548 AL564343
RefSeq transcript (Entrez)NM_012405 NM_170705
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ICMT
Cluster EST : UnigeneHs.515688 [ NCBI ]
CGAP (NCI)Hs.515688
Alternative Splicing GalleryENSG00000116237
Gene ExpressionICMT [ NCBI-GEO ]   ICMT [ EBI - ARRAY_EXPRESS ]   ICMT [ SEEK ]   ICMT [ MEM ]
Gene Expression Viewer (FireBrowse)ICMT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23463
GTEX Portal (Tissue expression)ICMT
Human Protein AtlasENSG00000116237-ICMT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60725   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60725  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60725
Splice isoforms : SwissVarO60725
Catalytic activity : Enzyme2.1.1.100 [ Enzyme-Expasy ]   2.1.1.1002.1.1.100 [ IntEnz-EBI ]   2.1.1.100 [ BRENDA ]   2.1.1.100 [ KEGG ]   
PhosPhoSitePlusO60725
Domaine pattern : Prosite (Expaxy)SAM_ICMT (PS51564)   
Domains : Interpro (EBI)ICMT_MeTrfase    PPMT_MeTrfase   
Domain families : Pfam (Sanger)ICMT (PF04140)   
Domain families : Pfam (NCBI)pfam04140   
Conserved Domain (NCBI)ICMT
DMDM Disease mutations23463
Blocks (Seattle)ICMT
SuperfamilyO60725
Human Protein Atlas [tissue]ENSG00000116237-ICMT [tissue]
Peptide AtlasO60725
HPRD09321
IPIIPI00031458   IPI01015532   IPI00385459   IPI00299935   
Protein Interaction databases
DIP (DOE-UCLA)O60725
IntAct (EBI)O60725
FunCoupENSG00000116237
BioGRIDICMT
STRING (EMBL)ICMT
ZODIACICMT
Ontologies - Pathways
QuickGOO60725
Ontology : AmiGOprotein C-terminal carboxyl O-methyltransferase activity  protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity  endoplasmic reticulum  endoplasmic reticulum membrane  cellular protein modification process  C-terminal protein methylation  protein targeting to membrane  membrane  integral component of membrane  post-translational protein modification  
Ontology : EGO-EBIprotein C-terminal carboxyl O-methyltransferase activity  protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity  endoplasmic reticulum  endoplasmic reticulum membrane  cellular protein modification process  C-terminal protein methylation  protein targeting to membrane  membrane  integral component of membrane  post-translational protein modification  
Pathways : KEGGTerpenoid backbone biosynthesis   
NDEx NetworkICMT
Atlas of Cancer Signalling NetworkICMT
Wikipedia pathwaysICMT
Orthology - Evolution
OrthoDB23463
GeneTree (enSembl)ENSG00000116237
Phylogenetic Trees/Animal Genes : TreeFamICMT
HOVERGENO60725
HOGENOMO60725
Homologs : HomoloGeneICMT
Homology/Alignments : Family Browser (UCSC)ICMT
Gene fusions - Rearrangements
Fusion : MitelmanICMT/GPR153 [1p36.31/1p36.31]  
Fusion PortalICMT 1p36.31 GPR153 1p36.31 BRCA
Fusion : QuiverICMT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerICMT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ICMT
dbVarICMT
ClinVarICMT
1000_GenomesICMT 
Exome Variant ServerICMT
ExAC (Exome Aggregation Consortium)ENSG00000116237
GNOMAD BrowserENSG00000116237
Varsome BrowserICMT
Genetic variants : HAPMAP23463
Genomic Variants (DGV)ICMT [DGVbeta]
DECIPHERICMT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisICMT 
Mutations
ICGC Data PortalICMT 
TCGA Data PortalICMT 
Broad Tumor PortalICMT
OASIS PortalICMT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICICMT  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDICMT
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ICMT
DgiDB (Drug Gene Interaction Database)ICMT
DoCM (Curated mutations)ICMT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ICMT (select a term)
intoGenICMT
Cancer3DICMT(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605851   
Orphanet
DisGeNETICMT
MedgenICMT
Genetic Testing Registry ICMT
NextProtO60725 [Medical]
TSGene23463
GENETestsICMT
Target ValidationICMT
Huge Navigator ICMT [HugePedia]
snp3D : Map Gene to Disease23463
BioCentury BCIQICMT
ClinGenICMT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23463
Chemical/Pharm GKB GenePA29598
Clinical trialICMT
Miscellaneous
canSAR (ICR)ICMT (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineICMT
EVEXICMT
GoPubMedICMT
iHOPICMT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:12:29 CET 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.