ICMT (isoprenylcysteine carboxyl methyltransferase)

2014-03-01  

Identity

HGNC
ICMT
LOCATION
1p36.31
LOCUSID
23463
ALIAS
HSTE14,MST098,MSTP098,PCCMT,PCMT,PPMT
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23463
MIM: 605851
HGNC: 5350
Ensembl: ENSG00000116237

Variants:

dbSNP: 23463
ClinVar: 23463
TCGA: ENSG00000116237
COSMIC: ICMT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116237ENST00000343813O60725
ENSG00000116237ENST00000343813A0A024R4F6
ENSG00000116237ENST00000474756K7EQW0
ENSG00000116237ENST00000489498Q7Z750

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Terpenoid backbone biosynthesisKEGGko00900
Terpenoid backbone biosynthesisKEGGhsa00900
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Gamma carboxylation, hypusine formation and arylsulfatase activationREACTOMER-HSA-163841

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
149665632004Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.64
191611602009An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).30
126317082003Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis.18
242164792013Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression.18
196517822009Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration.15
191582732009Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe.13
207985962011RHO methylation matters: a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion.11
281675042017Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer.10
251519672015Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism.8
286047482017Isoprenylcysteine carboxylmethyltransferase function is essential for RAB4A-mediated integrin β3 recycling, cell migration and cancer metastasis.8

Citation

Dessen P

ICMT (isoprenylcysteine carboxyl methyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2014-03-01

Online version: http://atlasgeneticsoncology.org/gene/53820/icmt