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ICOS (inducible T-cell co-stimulator)

Identity

Alias_symbol (synonym)AILIM
CD278
Other aliasCVID1
HGNC (Hugo) ICOS
LocusID (NCBI) 29851
Atlas_Id 50354
Location 2q33.2  [Link to chromosome band 2q33]
Location_base_pair Starts at 204801471 and ends at 204826298 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ICOS   5351
LRG (Locus Reference Genomic)LRG_65
Cards
Entrez_Gene (NCBI)ICOS  29851  inducible T-cell co-stimulator
AliasesAILIM; CD278; CVID1
GeneCards (Weizmann)ICOS
Ensembl hg19 (Hinxton)ENSG00000163600 [Gene_View]  chr2:204801471-204826298 [Contig_View]  ICOS [Vega]
Ensembl hg38 (Hinxton)ENSG00000163600 [Gene_View]  chr2:204801471-204826298 [Contig_View]  ICOS [Vega]
ICGC DataPortalENSG00000163600
TCGA cBioPortalICOS
AceView (NCBI)ICOS
Genatlas (Paris)ICOS
WikiGenes29851
SOURCE (Princeton)ICOS
Genetics Home Reference (NIH)ICOS
Genomic and cartography
GoldenPath hg19 (UCSC)ICOS  -     chr2:204801471-204826298 +  2q33.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ICOS  -     2q33.2   [Description]    (hg38-Dec_2013)
EnsemblICOS - 2q33.2 [CytoView hg19]  ICOS - 2q33.2 [CytoView hg38]
Mapping of homologs : NCBIICOS [Mapview hg19]  ICOS [Mapview hg38]
OMIM240500   604558   607594   
Gene and transcription
Genbank (Entrez)AB023135 AJ277832 AK314985 BC028006 BC028210
RefSeq transcript (Entrez)NM_012092
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_011586 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)ICOS
Cluster EST : UnigeneHs.56247 [ NCBI ]
CGAP (NCI)Hs.56247
Alternative Splicing GalleryENSG00000163600
Gene ExpressionICOS [ NCBI-GEO ]   ICOS [ EBI - ARRAY_EXPRESS ]   ICOS [ SEEK ]   ICOS [ MEM ]
Gene Expression Viewer (FireBrowse)ICOS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29851
GTEX Portal (Tissue expression)ICOS
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6W8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6W8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6W8
Splice isoforms : SwissVarQ9Y6W8
PhosPhoSitePlusQ9Y6W8
Domains : Interpro (EBI)Ig_V-set   
Domain families : Pfam (Sanger)V-set_2 (PF15910)   
Domain families : Pfam (NCBI)pfam15910   
Conserved Domain (NCBI)ICOS
DMDM Disease mutations29851
Blocks (Seattle)ICOS
SuperfamilyQ9Y6W8
Human Protein AtlasENSG00000163600
Peptide AtlasQ9Y6W8
HPRD09196
IPIIPI00424030   IPI00424031   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6W8
IntAct (EBI)Q9Y6W8
FunCoupENSG00000163600
BioGRIDICOS
STRING (EMBL)ICOS
ZODIACICOS
Ontologies - Pathways
QuickGOQ9Y6W8
Ontology : AmiGOT cell tolerance induction  extracellular region  plasma membrane  integral component of plasma membrane  immune response  external side of plasma membrane  single organismal cell-cell adhesion  T cell costimulation  
Ontology : EGO-EBIT cell tolerance induction  extracellular region  plasma membrane  integral component of plasma membrane  immune response  external side of plasma membrane  single organismal cell-cell adhesion  T cell costimulation  
Pathways : BIOCARTAThe Co-Stimulatory Signal During T-cell Activation [Genes]   
Pathways : KEGGCell adhesion molecules (CAMs)    T cell receptor signaling pathway    Intestinal immune network for IgA production    Primary immunodeficiency   
NDEx NetworkICOS
Atlas of Cancer Signalling NetworkICOS
Wikipedia pathwaysICOS
Orthology - Evolution
OrthoDB29851
GeneTree (enSembl)ENSG00000163600
Phylogenetic Trees/Animal Genes : TreeFamICOS
HOVERGENQ9Y6W8
HOGENOMQ9Y6W8
Homologs : HomoloGeneICOS
Homology/Alignments : Family Browser (UCSC)ICOS
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerICOS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ICOS
dbVarICOS
ClinVarICOS
1000_GenomesICOS 
Exome Variant ServerICOS
ExAC (Exome Aggregation Consortium)ICOS (select the gene name)
Genetic variants : HAPMAP29851
Genomic Variants (DGV)ICOS [DGVbeta]
DECIPHER (Syndromes)2:204801471-204826298  ENSG00000163600
CONAN: Copy Number AnalysisICOS 
Mutations
ICGC Data PortalICOS 
TCGA Data PortalICOS 
Broad Tumor PortalICOS
OASIS PortalICOS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICICOS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDICOS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch ICOS
DgiDB (Drug Gene Interaction Database)ICOS
DoCM (Curated mutations)ICOS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ICOS (select a term)
intoGenICOS
Cancer3DICOS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM240500    604558    607594   
Orphanet3469   
MedgenICOS
Genetic Testing Registry ICOS
NextProtQ9Y6W8 [Medical]
TSGene29851
GENETestsICOS
Huge Navigator ICOS [HugePedia]
snp3D : Map Gene to Disease29851
BioCentury BCIQICOS
ClinGenICOS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29851
Chemical/Pharm GKB GenePA29599
Clinical trialICOS
Miscellaneous
canSAR (ICR)ICOS (select the gene name)
Probes
Litterature
PubMed129 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineICOS
EVEXICOS
GoPubMedICOS
iHOPICOS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Mar 14 13:10:06 CET 2017

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