ICOSLG (inducible T cell costimulator ligand)

2007-02-01  

Identity

HGNC
ICOSLG
LOCATION
21q22.3
LOCUSID
23308
ALIAS
B7-H2,B7H2,B7RP-1,B7RP1,B7h,CD275,GL50,ICOS-L,ICOSL,LICOS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23308
MIM: 605717
HGNC: 17087
Ensembl: ENSG00000160223

Variants:

dbSNP: 23308
ClinVar: 23308
TCGA: ENSG00000160223
COSMIC: ICOSLG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160223ENST00000344330O75144
ENSG00000160223ENST00000400377O75144
ENSG00000160223ENST00000400379K4DIA0
ENSG00000160223ENST00000407780O75144
ENSG00000160223ENST00000407780A0N0L8
ENSG00000160223ENST00000643466A0A2R8Y5W7

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Costimulation by the CD28 familyREACTOMER-HSA-388841

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
185873942008Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.951
257696132015ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity.92
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
201767342010Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects.66
215303272011B7-h2 is a costimulatory ligand for CD28 in human.50
230261342012ICOS-ligand expression on plasmacytoid dendritic cells supports breast cancer progression by promoting the accumulation of immunosuppressive CD4+ T cells.49
151317962004The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cells.44
210987142010Melanoma cells express ICOS ligand to promote the activation and expansion of T-regulatory cells.33
254065812014Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity.33
129603062003Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis.32

Citation

Dessen P

ICOSLG (inducible T cell costimulator ligand)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46042/icoslg