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ID3 (inhibitor of DNA binding 3, HLH protein)

Identity

Alias_namesinhibitor of DNA binding 3
Alias_symbol (synonym)HEIR-1
bHLHb25
Other alias
HGNC (Hugo) ID3
LocusID (NCBI) 3399
Atlas_Id 40915
Location 1p36.12  [Link to chromosome band 1p36]
Location_base_pair Starts at 23557930 and ends at 23559794 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ID3 (1p36.12) / ID3 (1p36.12)NXN (17p13.3) / ID3 (1p36.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ID3   5362
Cards
Entrez_Gene (NCBI)ID3  3399  inhibitor of DNA binding 3, HLH protein
AliasesHEIR-1; bHLHb25
GeneCards (Weizmann)ID3
Ensembl hg19 (Hinxton)ENSG00000117318 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000117318 [Gene_View]  chr1:23557930-23559794 [Contig_View]  ID3 [Vega]
ICGC DataPortalENSG00000117318
TCGA cBioPortalID3
AceView (NCBI)ID3
Genatlas (Paris)ID3
WikiGenes3399
SOURCE (Princeton)ID3
Genetics Home Reference (NIH)ID3
Genomic and cartography
GoldenPath hg38 (UCSC)ID3  -     chr1:23557930-23559794 -  1p36.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ID3  -     1p36.12   [Description]    (hg19-Feb_2009)
EnsemblID3 - 1p36.12 [CytoView hg19]  ID3 - 1p36.12 [CytoView hg38]
Mapping of homologs : NCBIID3 [Mapview hg19]  ID3 [Mapview hg38]
OMIM600277   
Gene and transcription
Genbank (Entrez)A17546 A17548 AK225965 AK290003 BC003107
RefSeq transcript (Entrez)NM_002167
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ID3
Cluster EST : UnigeneHs.76884 [ NCBI ]
CGAP (NCI)Hs.76884
Alternative Splicing GalleryENSG00000117318
Gene ExpressionID3 [ NCBI-GEO ]   ID3 [ EBI - ARRAY_EXPRESS ]   ID3 [ SEEK ]   ID3 [ MEM ]
Gene Expression Viewer (FireBrowse)ID3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3399
GTEX Portal (Tissue expression)ID3
Human Protein AtlasENSG00000117318-ID3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02535   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02535  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02535
Splice isoforms : SwissVarQ02535
PhosPhoSitePlusQ02535
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)   
Domains : Interpro (EBI)bHLH_dom    DNA-bd_prot-inh   
Domain families : Pfam (Sanger)HLH (PF00010)   
Domain families : Pfam (NCBI)pfam00010   
Domain families : Smart (EMBL)HLH (SM00353)  
Conserved Domain (NCBI)ID3
DMDM Disease mutations3399
Blocks (Seattle)ID3
PDB (SRS)2LFH   
PDB (PDBSum)2LFH   
PDB (IMB)2LFH   
PDB (RSDB)2LFH   
Structural Biology KnowledgeBase2LFH   
SCOP (Structural Classification of Proteins)2LFH   
CATH (Classification of proteins structures)2LFH   
SuperfamilyQ02535
Human Protein Atlas [tissue]ENSG00000117318-ID3 [tissue]
Peptide AtlasQ02535
HPRD02608
IPIIPI00219112   
Protein Interaction databases
DIP (DOE-UCLA)Q02535
IntAct (EBI)Q02535
FunCoupENSG00000117318
BioGRIDID3
STRING (EMBL)ID3
ZODIACID3
Ontologies - Pathways
QuickGOQ02535
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  metanephros development  transcription factor activity, sequence-specific DNA binding  transcription corepressor activity  protein binding  nucleus  cytoplasm  regulation of DNA replication  transcription, DNA-templated  multicellular organism development  central nervous system development  heart development  muscle organ development  circadian rhythm  transcription factor binding  response to wounding  protein domain specific binding  neuron differentiation  epithelial cell differentiation  notochord development  odontogenesis  positive regulation of apoptotic process  negative regulation of sequence-specific DNA binding transcription factor activity  negative regulation of myoblast differentiation  negative regulation of osteoblast differentiation  negative regulation of transcription, DNA-templated  protein dimerization activity  regulation of cell cycle  cellular response to leptomycin B  leptomycin B binding  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  metanephros development  transcription factor activity, sequence-specific DNA binding  transcription corepressor activity  protein binding  nucleus  cytoplasm  regulation of DNA replication  transcription, DNA-templated  multicellular organism development  central nervous system development  heart development  muscle organ development  circadian rhythm  transcription factor binding  response to wounding  protein domain specific binding  neuron differentiation  epithelial cell differentiation  notochord development  odontogenesis  positive regulation of apoptotic process  negative regulation of sequence-specific DNA binding transcription factor activity  negative regulation of myoblast differentiation  negative regulation of osteoblast differentiation  negative regulation of transcription, DNA-templated  protein dimerization activity  regulation of cell cycle  cellular response to leptomycin B  leptomycin B binding  
Pathways : KEGGTGF-beta signaling pathway   
NDEx NetworkID3
Atlas of Cancer Signalling NetworkID3
Wikipedia pathwaysID3
Orthology - Evolution
OrthoDB3399
GeneTree (enSembl)ENSG00000117318
Phylogenetic Trees/Animal Genes : TreeFamID3
HOVERGENQ02535
HOGENOMQ02535
Homologs : HomoloGeneID3
Homology/Alignments : Family Browser (UCSC)ID3
Gene fusions - Rearrangements
Tumor Fusion PortalID3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerID3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ID3
dbVarID3
ClinVarID3
1000_GenomesID3 
Exome Variant ServerID3
ExAC (Exome Aggregation Consortium)ENSG00000117318
GNOMAD BrowserENSG00000117318
Genetic variants : HAPMAP3399
Genomic Variants (DGV)ID3 [DGVbeta]
DECIPHERID3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisID3 
Mutations
ICGC Data PortalID3 
TCGA Data PortalID3 
Broad Tumor PortalID3
OASIS PortalID3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICID3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDID3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ID3
DgiDB (Drug Gene Interaction Database)ID3
DoCM (Curated mutations)ID3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ID3 (select a term)
intoGenID3
Cancer3DID3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600277   
Orphanet
DisGeNETID3
MedgenID3
Genetic Testing Registry ID3
NextProtQ02535 [Medical]
TSGene3399
GENETestsID3
Target ValidationID3
Huge Navigator ID3 [HugePedia]
snp3D : Map Gene to Disease3399
BioCentury BCIQID3
ClinGenID3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3399
Chemical/Pharm GKB GenePA29610
Clinical trialID3
Miscellaneous
canSAR (ICR)ID3 (select the gene name)
Probes
Litterature
PubMed90 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineID3
EVEXID3
GoPubMedID3
iHOPID3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:17:11 CET 2017

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