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IDE (insulin degrading enzyme)

Identity

Alias (NCBI)INSULYSIN
HGNC (Hugo) IDE
HGNC Alias nameinsulysin
HGNC Previous nameinsulin-degrading enzyme
LocusID (NCBI) 3416
Atlas_Id 43739
Location 10q23.33  [Link to chromosome band 10q23]
Location_base_pair Starts at 92451684 and ends at 92574093 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ENTPD7 (10q24.2) / IDE (10q23.33)IDE (10q23.33) / CAMK1D (10p13)VWA2 (10q25.3) / IDE (10q23.33)
ENTPD7 10q24.2 / IDE 10q23.33IDE 10q23.33 / CAMK1D 10p13VWA2 10q25.3 / IDE 10q23.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)IDE   5381
Cards
Entrez_Gene (NCBI)IDE    insulin degrading enzyme
AliasesINSULYSIN
GeneCards (Weizmann)IDE
Ensembl hg19 (Hinxton)ENSG00000119912 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119912 [Gene_View]  ENSG00000119912 [Sequence]  chr10:92451684-92574093 [Contig_View]  IDE [Vega]
ICGC DataPortalENSG00000119912
TCGA cBioPortalIDE
AceView (NCBI)IDE
Genatlas (Paris)IDE
SOURCE (Princeton)IDE
Genetics Home Reference (NIH)IDE
Genomic and cartography
GoldenPath hg38 (UCSC)IDE  -     chr10:92451684-92574093 -  10q23.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IDE  -     10q23.33   [Description]    (hg19-Feb_2009)
GoldenPathIDE - 10q23.33 [CytoView hg19]  IDE - 10q23.33 [CytoView hg38]
ImmunoBaseENSG00000119912
Genome Data Viewer NCBIIDE [Mapview hg19]  
OMIM146680   
Gene and transcription
Genbank (Entrez)AB209204 AK093287 AK302578 AK312810 AK316407
RefSeq transcript (Entrez)NM_001165946 NM_001322793 NM_001322794 NM_001322795 NM_001322796 NM_001322797 NM_004969
Consensus coding sequences : CCDS (NCBI)IDE
Gene ExpressionIDE [ NCBI-GEO ]   IDE [ EBI - ARRAY_EXPRESS ]   IDE [ SEEK ]   IDE [ MEM ]
Gene Expression Viewer (FireBrowse)IDE [ Firebrowse - Broad ]
GenevisibleExpression of IDE in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3416
GTEX Portal (Tissue expression)IDE
Human Protein AtlasENSG00000119912-IDE [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14735   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP14735  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP14735
PhosPhoSitePlusP14735
Domaine pattern : Prosite (Expaxy)INSULINASE (PS00143)   
Domains : Interpro (EBI)Metalloenz_LuxS/M16    Pept_M16_N    Pept_M16_Zn_BS    Peptidase_M16_C    Peptidase_M16_M   
Domain families : Pfam (Sanger)Peptidase_M16 (PF00675)    Peptidase_M16_C (PF05193)    Peptidase_M16_M (PF16187)   
Domain families : Pfam (NCBI)pfam00675    pfam05193    pfam16187   
Conserved Domain (NCBI)IDE
PDB (RSDB)2G47    2G48    2G49    2G54    2G56    2JBU    2JG4    2WBY    2WC0    2WK3    2YPU    3CWW    3E4A    3E4Z    3E50    3H44    3HGZ    3N56    3N57    3OFI    3QZ2    4DTT    4DWK    4GS8    4GSC    4GSF    4IFH    4IOF    4LTE    4M1C    4NXO    4PES    4PF7    4PF9    4PFC    4QIA    4RAL    4RE9    5CJO    5UOE    5WOB    6B3Q    6B70    6B7Y    6B7Z    6BF6    6BF7    6BF8    6BF9    6BFC    6BYZ    6EDS    6MQ3   
PDB Europe2G47    2G48    2G49    2G54    2G56    2JBU    2JG4    2WBY    2WC0    2WK3    2YPU    3CWW    3E4A    3E4Z    3E50    3H44    3HGZ    3N56    3N57    3OFI    3QZ2    4DTT    4DWK    4GS8    4GSC    4GSF    4IFH    4IOF    4LTE    4M1C    4NXO    4PES    4PF7    4PF9    4PFC    4QIA    4RAL    4RE9    5CJO    5UOE    5WOB    6B3Q    6B70    6B7Y    6B7Z    6BF6    6BF7    6BF8    6BF9    6BFC    6BYZ    6EDS    6MQ3   
PDB (PDBSum)2G47    2G48    2G49    2G54    2G56    2JBU    2JG4    2WBY    2WC0    2WK3    2YPU    3CWW    3E4A    3E4Z    3E50    3H44    3HGZ    3N56    3N57    3OFI    3QZ2    4DTT    4DWK    4GS8    4GSC    4GSF    4IFH    4IOF    4LTE    4M1C    4NXO    4PES    4PF7    4PF9    4PFC    4QIA    4RAL    4RE9    5CJO    5UOE    5WOB    6B3Q    6B70    6B7Y    6B7Z    6BF6    6BF7    6BF8    6BF9    6BFC    6BYZ    6EDS    6MQ3   
PDB (IMB)2G47    2G48    2G49    2G54    2G56    2JBU    2JG4    2WBY    2WC0    2WK3    2YPU    3CWW    3E4A    3E4Z    3E50    3H44    3HGZ    3N56    3N57    3OFI    3QZ2    4DTT    4DWK    4GS8    4GSC    4GSF    4IFH    4IOF    4LTE    4M1C    4NXO    4PES    4PF7    4PF9    4PFC    4QIA    4RAL    4RE9    5CJO    5UOE    5WOB    6B3Q    6B70    6B7Y    6B7Z    6BF6    6BF7    6BF8    6BF9    6BFC    6BYZ    6EDS    6MQ3   
Structural Biology KnowledgeBase2G47    2G48    2G49    2G54    2G56    2JBU    2JG4    2WBY    2WC0    2WK3    2YPU    3CWW    3E4A    3E4Z    3E50    3H44    3HGZ    3N56    3N57    3OFI    3QZ2    4DTT    4DWK    4GS8    4GSC    4GSF    4IFH    4IOF    4LTE    4M1C    4NXO    4PES    4PF7    4PF9    4PFC    4QIA    4RAL    4RE9    5CJO    5UOE    5WOB    6B3Q    6B70    6B7Y    6B7Z    6BF6    6BF7    6BF8    6BF9    6BFC    6BYZ    6EDS    6MQ3   
SCOP (Structural Classification of Proteins)2G47    2G48    2G49    2G54    2G56    2JBU    2JG4    2WBY    2WC0    2WK3    2YPU    3CWW    3E4A    3E4Z    3E50    3H44    3HGZ    3N56    3N57    3OFI    3QZ2    4DTT    4DWK    4GS8    4GSC    4GSF    4IFH    4IOF    4LTE    4M1C    4NXO    4PES    4PF7    4PF9    4PFC    4QIA    4RAL    4RE9    5CJO    5UOE    5WOB    6B3Q    6B70    6B7Y    6B7Z    6BF6    6BF7    6BF8    6BF9    6BFC    6BYZ    6EDS    6MQ3   
CATH (Classification of proteins structures)2G47    2G48    2G49    2G54    2G56    2JBU    2JG4    2WBY    2WC0    2WK3    2YPU    3CWW    3E4A    3E4Z    3E50    3H44    3HGZ    3N56    3N57    3OFI    3QZ2    4DTT    4DWK    4GS8    4GSC    4GSF    4IFH    4IOF    4LTE    4M1C    4NXO    4PES    4PF7    4PF9    4PFC    4QIA    4RAL    4RE9    5CJO    5UOE    5WOB    6B3Q    6B70    6B7Y    6B7Z    6BF6    6BF7    6BF8    6BF9    6BFC    6BYZ    6EDS    6MQ3   
SuperfamilyP14735
AlphaFold pdb e-kbP14735   
Human Protein Atlas [tissue]ENSG00000119912-IDE [tissue]
HPRD00894
Protein Interaction databases
DIP (DOE-UCLA)P14735
IntAct (EBI)P14735
BioGRIDIDE
STRING (EMBL)IDE
ZODIACIDE
Ontologies - Pathways
QuickGOP14735
Ontology : AmiGOamyloid-beta binding  virus receptor activity  endopeptidase activity  metalloendopeptidase activity  metalloendopeptidase activity  protein binding  ATP binding  extracellular space  extracellular space  extracellular space  nucleus  nucleus  cytoplasm  mitochondrion  mitochondrion  peroxisome  peroxisome  peroxisomal matrix  peroxisomal matrix  cytosol  cytosol  proteolysis  protein localization  zinc ion binding  insulin receptor signaling pathway  determination of adult lifespan  external side of plasma membrane  cell surface  cell surface  bradykinin catabolic process  ubiquitin recycling  basolateral plasma membrane  antigen processing and presentation of endogenous peptide antigen via MHC class I  protein catabolic process  cytosolic proteasome complex  beta-endorphin binding  positive regulation of protein binding  peptide binding  hormone catabolic process  hormone catabolic process  protein homodimerization activity  peptide catabolic process  peptide catabolic process  insulin binding  insulin binding  cellular protein catabolic process  protein-containing complex binding  positive regulation of protein catabolic process  negative regulation of proteolysis  viral entry into host cell  amyloid-beta metabolic process  amyloid-beta metabolic process  proteolysis involved in cellular protein catabolic process  proteolysis involved in cellular protein catabolic process  extracellular exosome  amyloid-beta clearance  amyloid-beta clearance  ubiquitin-dependent protein binding  amyloid-beta clearance by cellular catabolic process  amyloid-beta clearance by cellular catabolic process  insulin metabolic process  insulin catabolic process  regulation of aerobic respiration  
Ontology : EGO-EBIamyloid-beta binding  virus receptor activity  endopeptidase activity  metalloendopeptidase activity  metalloendopeptidase activity  protein binding  ATP binding  extracellular space  extracellular space  extracellular space  nucleus  nucleus  cytoplasm  mitochondrion  mitochondrion  peroxisome  peroxisome  peroxisomal matrix  peroxisomal matrix  cytosol  cytosol  proteolysis  protein localization  zinc ion binding  insulin receptor signaling pathway  determination of adult lifespan  external side of plasma membrane  cell surface  cell surface  bradykinin catabolic process  ubiquitin recycling  basolateral plasma membrane  antigen processing and presentation of endogenous peptide antigen via MHC class I  protein catabolic process  cytosolic proteasome complex  beta-endorphin binding  positive regulation of protein binding  peptide binding  hormone catabolic process  hormone catabolic process  protein homodimerization activity  peptide catabolic process  peptide catabolic process  insulin binding  insulin binding  cellular protein catabolic process  protein-containing complex binding  positive regulation of protein catabolic process  negative regulation of proteolysis  viral entry into host cell  amyloid-beta metabolic process  amyloid-beta metabolic process  proteolysis involved in cellular protein catabolic process  proteolysis involved in cellular protein catabolic process  extracellular exosome  amyloid-beta clearance  amyloid-beta clearance  ubiquitin-dependent protein binding  amyloid-beta clearance by cellular catabolic process  amyloid-beta clearance by cellular catabolic process  insulin metabolic process  insulin catabolic process  regulation of aerobic respiration  
Pathways : KEGGAlzheimer's disease   
NDEx NetworkIDE
Atlas of Cancer Signalling NetworkIDE
Wikipedia pathwaysIDE
Orthology - Evolution
OrthoDB3416
GeneTree (enSembl)ENSG00000119912
Phylogenetic Trees/Animal Genes : TreeFamIDE
Homologs : HomoloGeneIDE
Homology/Alignments : Family Browser (UCSC)IDE
Gene fusions - Rearrangements
Fusion : MitelmanENTPD7/IDE [10q24.2/10q23.33]  
Fusion : MitelmanIDE/CAMK1D [10q23.33/10p13]  
Fusion : MitelmanVWA2/IDE [10q25.3/10q23.33]  
Fusion : QuiverIDE
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIDE [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IDE
dbVarIDE
ClinVarIDE
MonarchIDE
1000_GenomesIDE 
Exome Variant ServerIDE
GNOMAD BrowserENSG00000119912
Varsome BrowserIDE
ACMGIDE variants
VarityP14735
Genomic Variants (DGV)IDE [DGVbeta]
DECIPHERIDE [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIDE 
Mutations
ICGC Data PortalIDE 
TCGA Data PortalIDE 
Broad Tumor PortalIDE
OASIS PortalIDE [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIDE  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIDE
Mutations and Diseases : HGMDIDE
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIDE
DgiDB (Drug Gene Interaction Database)IDE
DoCM (Curated mutations)IDE
CIViC (Clinical Interpretations of Variants in Cancer)IDE
Cancer3DIDE
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146680   
Orphanet
DisGeNETIDE
MedgenIDE
Genetic Testing Registry IDE
NextProtP14735 [Medical]
GENETestsIDE
Target ValidationIDE
Huge Navigator IDE [HugePedia]
ClinGenIDE
Clinical trials, drugs, therapy
MyCancerGenomeIDE
Protein Interactions : CTDIDE
Pharm GKB GenePA29629
PharosP14735
Clinical trialIDE
Miscellaneous
canSAR (ICR)IDE
HarmonizomeIDE
DataMed IndexIDE
Probes
Litterature
PubMed204 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIDE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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