Atlas of Genetics and Cytogenetics in Oncology and Haematology


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IDE (insulin degrading enzyme)

Identity

Alias_namesinsulin-degrading enzyme
Other aliasINSULYSIN
HGNC (Hugo) IDE
LocusID (NCBI) 3416
Atlas_Id 43739
Location 10q23.33  [Link to chromosome band 10q23]
Location_base_pair Starts at 92451684 and ends at 92574095 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ENTPD7 (10q24.2) / IDE (10q23.33)IDE (10q23.33) / CAMK1D (10p13)VWA2 (10q25.3) / IDE (10q23.33)
ENTPD7 10q24.2 / IDE 10q23.33IDE 10q23.33 / CAMK1D 10p13VWA2 10q25.3 / IDE 10q23.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(10;10)(p13;q23) IDE/CAMK1D
t(10;10)(q23;q24) ENTPD7/IDE
t(10;10)(q23;q25) VWA2/IDE


External links

Nomenclature
HGNC (Hugo)IDE   5381
Cards
Entrez_Gene (NCBI)IDE  3416  insulin degrading enzyme
AliasesINSULYSIN
GeneCards (Weizmann)IDE
Ensembl hg19 (Hinxton)ENSG00000119912 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119912 [Gene_View]  ENSG00000119912 [Sequence]  chr10:92451684-92574095 [Contig_View]  IDE [Vega]
ICGC DataPortalENSG00000119912
TCGA cBioPortalIDE
AceView (NCBI)IDE
Genatlas (Paris)IDE
WikiGenes3416
SOURCE (Princeton)IDE
Genetics Home Reference (NIH)IDE
Genomic and cartography
GoldenPath hg38 (UCSC)IDE  -     chr10:92451684-92574095 -  10q23.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IDE  -     10q23.33   [Description]    (hg19-Feb_2009)
EnsemblIDE - 10q23.33 [CytoView hg19]  IDE - 10q23.33 [CytoView hg38]
Mapping of homologs : NCBIIDE [Mapview hg19]  IDE [Mapview hg38]
OMIM146680   
Gene and transcription
Genbank (Entrez)AB209204 AK093287 AK302578 AK312810 AK316407
RefSeq transcript (Entrez)NM_001165946 NM_001322793 NM_001322794 NM_001322795 NM_001322796 NM_001322797 NM_004969
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IDE
Cluster EST : UnigeneHs.500546 [ NCBI ]
CGAP (NCI)Hs.500546
Alternative Splicing GalleryENSG00000119912
Gene ExpressionIDE [ NCBI-GEO ]   IDE [ EBI - ARRAY_EXPRESS ]   IDE [ SEEK ]   IDE [ MEM ]
Gene Expression Viewer (FireBrowse)IDE [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3416
GTEX Portal (Tissue expression)IDE
Human Protein AtlasENSG00000119912-IDE [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14735   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP14735  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP14735
Splice isoforms : SwissVarP14735
Catalytic activity : Enzyme3.4.24.56 [ Enzyme-Expasy ]   3.4.24.563.4.24.56 [ IntEnz-EBI ]   3.4.24.56 [ BRENDA ]   3.4.24.56 [ KEGG ]   
PhosPhoSitePlusP14735
Domaine pattern : Prosite (Expaxy)INSULINASE (PS00143)   
Domains : Interpro (EBI)Metalloenz_LuxS/M16    Pept_M16_N    Pept_M16_Zn_BS    Peptidase_M16_C    Peptidase_M16_M   
Domain families : Pfam (Sanger)Peptidase_M16 (PF00675)    Peptidase_M16_C (PF05193)    Peptidase_M16_M (PF16187)   
Domain families : Pfam (NCBI)pfam00675    pfam05193    pfam16187   
Conserved Domain (NCBI)IDE
DMDM Disease mutations3416
Blocks (Seattle)IDE
PDB (SRS)2G47    2G48    2G49    2G54    2G56    2JBU    2JG4    2WBY    2WC0    2WK3    2YPU    3CWW    3E4A    3E4Z    3E50    3H44    3HGZ    3N56    3N57    3OFI    3QZ2    4DTT    4DWK    4GS8    4GSC    4GSF    4IFH    4IOF    4LTE    4M1C    4NXO    4PES    4PF7    4PF9    4PFC    4Q5Z    4QIA    4RAL    4RE9    5CJO    5UOE    6B3Q    6B70    6B7Y    6B7Z    6BF6    6BF7    6BF9    6BFC   
PDB (PDBSum)2G47    2G48    2G49    2G54    2G56    2JBU    2JG4    2WBY    2WC0    2WK3    2YPU    3CWW    3E4A    3E4Z    3E50    3H44    3HGZ    3N56    3N57    3OFI    3QZ2    4DTT    4DWK    4GS8    4GSC    4GSF    4IFH    4IOF    4LTE    4M1C    4NXO    4PES    4PF7    4PF9    4PFC    4Q5Z    4QIA    4RAL    4RE9    5CJO    5UOE    6B3Q    6B70    6B7Y    6B7Z    6BF6    6BF7    6BF9    6BFC   
PDB (IMB)2G47    2G48    2G49    2G54    2G56    2JBU    2JG4    2WBY    2WC0    2WK3    2YPU    3CWW    3E4A    3E4Z    3E50    3H44    3HGZ    3N56    3N57    3OFI    3QZ2    4DTT    4DWK    4GS8    4GSC    4GSF    4IFH    4IOF    4LTE    4M1C    4NXO    4PES    4PF7    4PF9    4PFC    4Q5Z    4QIA    4RAL    4RE9    5CJO    5UOE    6B3Q    6B70    6B7Y    6B7Z    6BF6    6BF7    6BF9    6BFC   
PDB (RSDB)2G47    2G48    2G49    2G54    2G56    2JBU    2JG4    2WBY    2WC0    2WK3    2YPU    3CWW    3E4A    3E4Z    3E50    3H44    3HGZ    3N56    3N57    3OFI    3QZ2    4DTT    4DWK    4GS8    4GSC    4GSF    4IFH    4IOF    4LTE    4M1C    4NXO    4PES    4PF7    4PF9    4PFC    4Q5Z    4QIA    4RAL    4RE9    5CJO    5UOE    6B3Q    6B70    6B7Y    6B7Z    6BF6    6BF7    6BF9    6BFC   
Structural Biology KnowledgeBase2G47    2G48    2G49    2G54    2G56    2JBU    2JG4    2WBY    2WC0    2WK3    2YPU    3CWW    3E4A    3E4Z    3E50    3H44    3HGZ    3N56    3N57    3OFI    3QZ2    4DTT    4DWK    4GS8    4GSC    4GSF    4IFH    4IOF    4LTE    4M1C    4NXO    4PES    4PF7    4PF9    4PFC    4Q5Z    4QIA    4RAL    4RE9    5CJO    5UOE    6B3Q    6B70    6B7Y    6B7Z    6BF6    6BF7    6BF9    6BFC   
SCOP (Structural Classification of Proteins)2G47    2G48    2G49    2G54    2G56    2JBU    2JG4    2WBY    2WC0    2WK3    2YPU    3CWW    3E4A    3E4Z    3E50    3H44    3HGZ    3N56    3N57    3OFI    3QZ2    4DTT    4DWK    4GS8    4GSC    4GSF    4IFH    4IOF    4LTE    4M1C    4NXO    4PES    4PF7    4PF9    4PFC    4Q5Z    4QIA    4RAL    4RE9    5CJO    5UOE    6B3Q    6B70    6B7Y    6B7Z    6BF6    6BF7    6BF9    6BFC   
CATH (Classification of proteins structures)2G47    2G48    2G49    2G54    2G56    2JBU    2JG4    2WBY    2WC0    2WK3    2YPU    3CWW    3E4A    3E4Z    3E50    3H44    3HGZ    3N56    3N57    3OFI    3QZ2    4DTT    4DWK    4GS8    4GSC    4GSF    4IFH    4IOF    4LTE    4M1C    4NXO    4PES    4PF7    4PF9    4PFC    4Q5Z    4QIA    4RAL    4RE9    5CJO    5UOE    6B3Q    6B70    6B7Y    6B7Z    6BF6    6BF7    6BF9    6BFC   
SuperfamilyP14735
Human Protein Atlas [tissue]ENSG00000119912-IDE [tissue]
Peptide AtlasP14735
HPRD00894
IPIIPI00220373   IPI00946216   IPI00514444   
Protein Interaction databases
DIP (DOE-UCLA)P14735
IntAct (EBI)P14735
FunCoupENSG00000119912
BioGRIDIDE
STRING (EMBL)IDE
ZODIACIDE
Ontologies - Pathways
QuickGOP14735
Ontology : AmiGOamyloid-beta binding  virus receptor activity  metalloendopeptidase activity  signaling receptor binding  protein binding  ATP binding  extracellular space  nucleus  nucleus  cytoplasm  mitochondrion  mitochondrion  peroxisome  peroxisomal matrix  peroxisomal matrix  cytosol  cytosol  plasma membrane  proteolysis  protein targeting to peroxisome  zinc ion binding  insulin receptor signaling pathway  determination of adult lifespan  cell surface  bradykinin catabolic process  ubiquitin recycling  ATPase activity  cytosolic proteasome complex  beta-endorphin binding  positive regulation of protein oligomerization  peptide binding  hormone catabolic process  protein homodimerization activity  insulin binding  insulin binding  positive regulation of protein catabolic process  negative regulation of proteolysis  viral entry into host cell  amyloid-beta metabolic process  amyloid-beta metabolic process  protein homooligomerization  protein homotetramerization  protein heterooligomerization  proteolysis involved in cellular protein catabolic process  proteolysis involved in cellular protein catabolic process  amyloid-beta clearance  ubiquitin-dependent protein binding  insulin metabolic process  insulin catabolic process  
Ontology : EGO-EBIamyloid-beta binding  virus receptor activity  metalloendopeptidase activity  signaling receptor binding  protein binding  ATP binding  extracellular space  nucleus  nucleus  cytoplasm  mitochondrion  mitochondrion  peroxisome  peroxisomal matrix  peroxisomal matrix  cytosol  cytosol  plasma membrane  proteolysis  protein targeting to peroxisome  zinc ion binding  insulin receptor signaling pathway  determination of adult lifespan  cell surface  bradykinin catabolic process  ubiquitin recycling  ATPase activity  cytosolic proteasome complex  beta-endorphin binding  positive regulation of protein oligomerization  peptide binding  hormone catabolic process  protein homodimerization activity  insulin binding  insulin binding  positive regulation of protein catabolic process  negative regulation of proteolysis  viral entry into host cell  amyloid-beta metabolic process  amyloid-beta metabolic process  protein homooligomerization  protein homotetramerization  protein heterooligomerization  proteolysis involved in cellular protein catabolic process  proteolysis involved in cellular protein catabolic process  amyloid-beta clearance  ubiquitin-dependent protein binding  insulin metabolic process  insulin catabolic process  
Pathways : KEGGAlzheimer's disease   
NDEx NetworkIDE
Atlas of Cancer Signalling NetworkIDE
Wikipedia pathwaysIDE
Orthology - Evolution
OrthoDB3416
GeneTree (enSembl)ENSG00000119912
Phylogenetic Trees/Animal Genes : TreeFamIDE
HOVERGENP14735
HOGENOMP14735
Homologs : HomoloGeneIDE
Homology/Alignments : Family Browser (UCSC)IDE
Gene fusions - Rearrangements
Fusion : MitelmanENTPD7/IDE [10q24.2/10q23.33]  [t(10;10)(q23;q24)]  
Fusion : MitelmanIDE/CAMK1D [10q23.33/10p13]  [t(10;10)(p13;q23)]  
Fusion : MitelmanVWA2/IDE [10q25.3/10q23.33]  [t(10;10)(q23;q25)]  
Fusion PortalENTPD7 10q24.2 IDE 10q23.33 GBM
Fusion PortalIDE 10q23.33 CAMK1D 10p13 PRAD
Fusion PortalVWA2 10q25.3 IDE 10q23.33 LGG
Fusion : QuiverIDE
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIDE [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IDE
dbVarIDE
ClinVarIDE
1000_GenomesIDE 
Exome Variant ServerIDE
ExAC (Exome Aggregation Consortium)ENSG00000119912
GNOMAD BrowserENSG00000119912
Varsome BrowserIDE
Genetic variants : HAPMAP3416
Genomic Variants (DGV)IDE [DGVbeta]
DECIPHERIDE [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIDE 
Mutations
ICGC Data PortalIDE 
TCGA Data PortalIDE 
Broad Tumor PortalIDE
OASIS PortalIDE [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIDE  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIDE
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch IDE
DgiDB (Drug Gene Interaction Database)IDE
DoCM (Curated mutations)IDE (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IDE (select a term)
intoGenIDE
Cancer3DIDE(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146680   
Orphanet
DisGeNETIDE
MedgenIDE
Genetic Testing Registry IDE
NextProtP14735 [Medical]
TSGene3416
GENETestsIDE
Target ValidationIDE
Huge Navigator IDE [HugePedia]
snp3D : Map Gene to Disease3416
BioCentury BCIQIDE
ClinGenIDE
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3416
Chemical/Pharm GKB GenePA29629
Clinical trialIDE
Miscellaneous
canSAR (ICR)IDE (select the gene name)
Probes
Litterature
PubMed183 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIDE
EVEXIDE
GoPubMedIDE
iHOPIDE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:12:31 CET 2018

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