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IDH1 (isocitrate dehydrogenase 1 (NADP+), soluble)

Identity

Other namesIDCD
IDH
IDP
IDPC
PICD
HGNC (Hugo) IDH1
LocusID (NCBI) 3417
Location 2q34
Location_base_pair Starts at 209100951 and ends at 209119182 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IDH1   5382
Cards
Entrez_Gene (NCBI)IDH1  3417  isocitrate dehydrogenase 1 (NADP+), soluble
GeneCards (Weizmann)IDH1
Ensembl (Hinxton)ENSG00000138413 [Gene_View]  chr2:209100951-209119182 [Contig_View]  IDH1 [Vega]
ICGC DataPortalENSG00000138413
cBioPortalIDH1
AceView (NCBI)IDH1
Genatlas (Paris)IDH1
WikiGenes3417
SOURCE (Princeton)NM_001282386 NM_001282387 NM_005896
Genomic and cartography
GoldenPath (UCSC)IDH1  -  2q34   chr2:209100951-209119182 -  2q34   [Description]    (hg19-Feb_2009)
EnsemblIDH1 - 2q34 [CytoView]
Mapping of homologs : NCBIIDH1 [Mapview]
OMIM137800   147700   
Gene and transcription
Genbank (Entrez)AF020038 AF113917 AK302105 AK312242 AL136702
RefSeq transcript (Entrez)NM_001282386 NM_001282387 NM_005896
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_023319 NT_005403 NW_001838863 NW_004929305
Consensus coding sequences : CCDS (NCBI)IDH1
Cluster EST : UnigeneHs.593422 [ NCBI ]
CGAP (NCI)Hs.593422
Alternative Splicing : Fast-db (Paris)GSHG0018312
Alternative Splicing GalleryENSG00000138413
Gene ExpressionIDH1 [ NCBI-GEO ]     IDH1 [ SEEK ]   IDH1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75874 (Uniprot)
NextProtO75874  [Medical]
With graphics : InterProO75874
Splice isoforms : SwissVarO75874 (Swissvar)
Catalytic activity : Enzyme1.1.1.42 [ Enzyme-Expasy ]   1.1.1.421.1.1.42 [ IntEnz-EBI ]   1.1.1.42 [ BRENDA ]   1.1.1.42 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)IDH_IMDH (PS00470)   
Domains : Interpro (EBI)IsoCit/isopropylmalate_DH_CS [organisation]   Isocitrate_DH_NADP [organisation]   IsoPropMal-DH-like_dom [organisation]  
Related proteins : CluSTrO75874
Domain families : Pfam (Sanger)Iso_dh (PF00180)   
Domain families : Pfam (NCBI)pfam00180   
DMDM Disease mutations3417
Blocks (Seattle)O75874
PDB (SRS)1T09    1T0L    3INM    3MAP    3MAR    3MAS    4I3K    4I3L    4KZO    4L03   
PDB (PDBSum)1T09    1T0L    3INM    3MAP    3MAR    3MAS    4I3K    4I3L    4KZO    4L03   
PDB (IMB)1T09    1T0L    3INM    3MAP    3MAR    3MAS    4I3K    4I3L    4KZO    4L03   
PDB (RSDB)1T09    1T0L    3INM    3MAP    3MAR    3MAS    4I3K    4I3L    4KZO    4L03   
Human Protein AtlasENSG00000138413 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasO75874
HPRD00984
IPIIPI00027223   IPI00023029   IPI00924576   IPI00927373   IPI00925000   
Protein Interaction databases
DIP (DOE-UCLA)O75874
IntAct (EBI)O75874
FunCoupENSG00000138413
BioGRIDIDH1
InParanoidO75874
Interologous Interaction database O75874
IntegromeDBIDH1
STRING (EMBL)IDH1
Ontologies - Pathways
Ontology : AmiGOmagnesium ion binding  isocitrate dehydrogenase (NADP+) activity  isocitrate dehydrogenase (NADP+) activity  receptor binding  cytoplasm  mitochondrion  peroxisome  peroxisomal matrix  cytosol  cytosol  glyoxylate cycle  tricarboxylic acid cycle  isocitrate metabolic process  2-oxoglutarate metabolic process  2-oxoglutarate metabolic process  NADPH regeneration  glutathione metabolic process  response to oxidative stress  female gonad development  protein homodimerization activity  cellular lipid metabolic process  small molecule metabolic process  response to steroid hormone  NADP binding  NAD binding  
Ontology : EGO-EBImagnesium ion binding  isocitrate dehydrogenase (NADP+) activity  isocitrate dehydrogenase (NADP+) activity  receptor binding  cytoplasm  mitochondrion  peroxisome  peroxisomal matrix  cytosol  cytosol  glyoxylate cycle  tricarboxylic acid cycle  isocitrate metabolic process  2-oxoglutarate metabolic process  2-oxoglutarate metabolic process  NADPH regeneration  glutathione metabolic process  response to oxidative stress  female gonad development  protein homodimerization activity  cellular lipid metabolic process  small molecule metabolic process  response to steroid hormone  NADP binding  NAD binding  
Pathways : KEGGCitrate cycle (TCA cycle)    Glutathione metabolism    Peroxisome   
Protein Interaction DatabaseIDH1
Wikipedia pathwaysIDH1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)IDH1
snp3D : Map Gene to Disease3417
SNP (GeneSNP Utah)IDH1
SNP : HGBaseIDH1
Genetic variants : HAPMAPIDH1
Exome VariantIDH1
1000_GenomesIDH1 
ICGC programENSG00000138413 
Cancer Gene: CensusIDH1 
Somatic Mutations in Cancer : COSMICIDH1 
CONAN: Copy Number AnalysisIDH1 
Mutations and Diseases : HGMDIDH1
Genomic VariantsIDH1  IDH1 [DGVbeta]
dbVarIDH1
ClinVarIDH1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM137800    147700   
MedgenIDH1
GENETestsIDH1
Disease Genetic AssociationIDH1
Huge Navigator IDH1 [HugePedia]  IDH1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneIDH1
Homology/Alignments : Family Browser (UCSC)IDH1
Phylogenetic Trees/Animal Genes : TreeFamIDH1
Chemical/Protein Interactions : CTD3417
Chemical/Pharm GKB GenePA29630
Drug Sensitivity IDH1
Clinical trialIDH1
Cancer Resource (Charite)ENSG00000138413
Other databases
Probes
Litterature
PubMed295 Pubmed reference(s) in Entrez
CoreMineIDH1
iHOPIDH1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jul 11 16:59:41 CEST 2014

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