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IDH2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial)

Identity

Other namesD2HGA2
ICD-M
IDH
IDHM
IDP
IDPM
mNADP-IDH
HGNC (Hugo) IDH2
LocusID (NCBI) 3418
Location 15q26.1
Location_base_pair Starts at 90627211 and ends at 90643853 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IDH2   5383
Cards
Entrez_Gene (NCBI)IDH2  3418  isocitrate dehydrogenase 2 (NADP+), mitochondrial
GeneCards (Weizmann)IDH2
Ensembl (Hinxton)ENSG00000182054 [Gene_View]  chr15:90627211-90643853 [Contig_View]  IDH2 [Vega]
ICGC DataPortalENSG00000182054
AceView (NCBI)IDH2
Genatlas (Paris)IDH2
WikiGenes3418
SOURCE (Princeton)NM_001289910 NM_001290114 NM_002168
Genomic and cartography
GoldenPath (UCSC)IDH2  -  15q26.1   chr15:90627211-90643853 -  15q26.1   [Description]    (hg19-Feb_2009)
EnsemblIDH2 - 15q26.1 [CytoView]
Mapping of homologs : NCBIIDH2 [Mapview]
OMIM147650   613657   
Gene and transcription
Genbank (Entrez)AK222916 AK294148 AK299987 AK312627 AK316388
RefSeq transcript (Entrez)NM_001289910 NM_001290114 NM_002168
RefSeq genomic (Entrez)AC_000147 NC_000015 NC_018926 NG_023302 NT_010194 NW_001838222 NW_004929399
Consensus coding sequences : CCDS (NCBI)IDH2
Cluster EST : UnigeneHs.596461 [ NCBI ]
CGAP (NCI)Hs.596461
Alternative Splicing : Fast-db (Paris)GSHG0010720
Alternative Splicing GalleryENSG00000182054
Gene ExpressionIDH2 [ NCBI-GEO ]     IDH2 [ SEEK ]   IDH2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48735 (Uniprot)
NextProtP48735  [Medical]
With graphics : InterProP48735
Splice isoforms : SwissVarP48735 (Swissvar)
Catalytic activity : Enzyme1.1.1.42 [ Enzyme-Expasy ]   1.1.1.421.1.1.42 [ IntEnz-EBI ]   1.1.1.42 [ BRENDA ]   1.1.1.42 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)IDH_IMDH (PS00470)   
Domains : Interpro (EBI)IsoCit/isopropylmalate_DH_CS    Isocitrate_DH_NADP    IsoPropMal-DH-like_dom   
Related proteins : CluSTrP48735
Domain families : Pfam (Sanger)Iso_dh (PF00180)   
Domain families : Pfam (NCBI)pfam00180   
DMDM Disease mutations3418
Blocks (Seattle)P48735
PDB (SRS)4JA8   
PDB (PDBSum)4JA8   
PDB (IMB)4JA8   
PDB (RSDB)4JA8   
Human Protein AtlasENSG00000182054
Peptide AtlasP48735
HPRD00973
IPIIPI00011107   IPI01015385   IPI01010649   
Protein Interaction databases
DIP (DOE-UCLA)P48735
IntAct (EBI)P48735
FunCoupENSG00000182054
BioGRIDIDH2
IntegromeDBIDH2
STRING (EMBL)IDH2
Ontologies - Pathways
QuickGOP48735
Ontology : AmiGOmagnesium ion binding  isocitrate dehydrogenase (NADP+) activity  isocitrate dehydrogenase (NADP+) activity  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  carbohydrate metabolic process  glyoxylate cycle  tricarboxylic acid cycle  isocitrate metabolic process  2-oxoglutarate metabolic process  cellular metabolic process  small molecule metabolic process  NAD binding  
Ontology : EGO-EBImagnesium ion binding  isocitrate dehydrogenase (NADP+) activity  isocitrate dehydrogenase (NADP+) activity  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  carbohydrate metabolic process  glyoxylate cycle  tricarboxylic acid cycle  isocitrate metabolic process  2-oxoglutarate metabolic process  cellular metabolic process  small molecule metabolic process  NAD binding  
Pathways : KEGGCitrate cycle (TCA cycle)    Glutathione metabolism    Peroxisome   
Protein Interaction DatabaseIDH2
Wikipedia pathwaysIDH2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)IDH2
SNP (GeneSNP Utah)IDH2
SNP : HGBaseIDH2
Genetic variants : HAPMAPIDH2
1000_GenomesIDH2 
ICGC programENSG00000182054 
Cancer Gene: CensusIDH2 
CONAN: Copy Number AnalysisIDH2 
Somatic Mutations in Cancer : COSMICIDH2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
LOVD (Leiden Open Variation Database)Vascular Anomaly and Lymphedema Mutation Database
DECIPHER (Syndromes)15:90627211-90643853
Mutations and Diseases : HGMDIDH2
OMIM147650    613657   
MedgenIDH2
GENETestsIDH2
Disease Genetic AssociationIDH2
Huge Navigator IDH2 [HugePedia]  IDH2 [HugeCancerGEM]
Genomic VariantsIDH2  IDH2 [DGVbeta]
Exome VariantIDH2
dbVarIDH2
ClinVarIDH2
snp3D : Map Gene to Disease3418
General knowledge
Homologs : HomoloGeneIDH2
Homology/Alignments : Family Browser (UCSC)IDH2
Phylogenetic Trees/Animal Genes : TreeFamIDH2
Chemical/Protein Interactions : CTD3418
Chemical/Pharm GKB GenePA29631
Clinical trialIDH2
Cancer Resource (Charite)ENSG00000182054
Other databases
Probes
Litterature
PubMed179 Pubmed reference(s) in Entrez
CoreMineIDH2
GoPubMedIDH2
iHOPIDH2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Nov 8 17:33:09 CET 2014

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