Atlas of Genetics and Cytogenetics in Oncology and Haematology

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IDH2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial)

Identity

Other namesD2HGA2
ICD-M
IDH
IDHM
IDP
IDPM
mNADP-IDH
HGNC (Hugo) IDH2
LocusID (NCBI) 3418
Location 15q26.1
Location_base_pair Starts at 90627212 and ends at 90645708 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)IDH2   5383
Entrez_Gene (NCBI)IDH2  3418  isocitrate dehydrogenase 2 (NADP+), mitochondrial
Cards
GeneCards (Weizmann)IDH2
Ensembl (Hinxton)ENSG00000182054 [Gene_View]  chr15:90627212-90645708 [Contig_View]  IDH2 [Vega]
AceView (NCBI)IDH2
Genatlas (Paris)IDH2
SOURCE (Stanford)NM_002168
Genomic and cartography
GoldenPath (UCSC)IDH2  -  15q26.1   chr15:90627212-90645708 -  15q26.1   [Description]    (hg19-Feb_2009)
EnsemblIDH2 - 15q26.1 [CytoView]
Mapping of homologs : NCBIIDH2 [Mapview]
OMIM147650   613657   
Gene and transcription
Genbank (Entrez)AK222916 AK294148 AK299987 AK312627 AK316388
RefSeq transcript (SRS)NM_002168
RefSeq transcript (Entrez)NM_002168
RefSeq genomic (SRS)AC_000147 NC_000015 NC_018926 NG_023302 NT_010274 NW_001838222 NW_004078084
RefSeq genomic (Entrez)AC_000147 NC_000015 NC_018926 NG_023302 NT_010274 NW_001838222 NW_004078084
Consensus coding sequences : CCDS (NCBI)IDH2
Cluster EST : UnigeneHs.596461 [ SRS ] Hs.596461 [ NCBI ]
CGAP (NCI)Hs.596461
Alternative Splicing : Fast-db (Paris)GSHG0010720
Alternative Splicing GalleryENSG00000182054
Gene ExpressionIDH2 [ NCBI-GEO ]   IDH2 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48735 (SRS) P48735 (Uniprot)
NextProtP48735
With graphics : InterProP48735
Splice isoforms : SwissVarP48735(Swissvar)
Domaine pattern : Prosite (SRS)IDH_IMDH (PS00470)   
Domaine pattern : Prosite (Expaxy)IDH_IMDH (PS00470)   
Domains : Interpro (SRS)IsoCit/isopropylmalate_DH_CS    Isocitrate_DH_NADP    IsoPropMal-DH-like_dom   
Domains : Interpro (EBI)IsoCit/isopropylmalate_DH_CS    Isocitrate_DH_NADP    IsoPropMal-DH-like_dom   
Related proteins : CluSTrP48735
Domain families : Pfam (SRS)Iso_dh (PF00180)   
Domain families : Pfam (Sanger)Iso_dh (PF00180)   
Domain families : Pfam (NCBI)pfam00180   
DMDM3418
Blocks (Seattle)P48735
Human Protein AtlasENSG00000182054
HPRD00973
IPIIPI00011107   IPI01015385   IPI01010649   
Protein Interaction databases
DIP (DOE-UCLA)P48735
IntAct (EBI)P48735
FunCoupENSG00000182054
REACTOMEIDH2
Protein Interaction Database3418
BioGRIDIDH2
InParanoidP48735
Interologous Interaction database P48735
IntegromeDBIDH2
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)IDH2
SNP (GeneSNP Utah)IDH2
SNP : HGBaseIDH2
Genetic variants : HAPMAPIDH2
Cancer Gene: CensusIDH2 
Somatic Mutations in Cancer : COSMICIDH2 
CONAN: Copy Number AnalysisIDH2 
Mutations and Diseases : HGMDIDH2
OMIM147650    613657   
GENETests147650    613657   
Disease Genetic AssociationIDH2
Huge Navigator IDH2 [HugePedia]  IDH2 [HugeCancerGEM]
Genomic VariantsIDH2  IDH2 [DGVbeta]
snp3D : Map Gene to Disease3418
General knowledge
Homologs : HomoloGeneIDH2
Homology/Alignments : Family Browser (UCSC)IDH2
Phylogenetic Trees/Animal Genes : TreeFamIDH2
Catalytic activity : Enzyme1.1.1.42 [ Enzyme-Expasy ]   1.1.1.42 [ Enzyme-SRS ]   1.1.1.42 [ IntEnz-EBI ]   1.1.1.42 [ BRENDA ]   1.1.1.42 [ KEGG ]   
Chemical/Protein Interactions : CTD3418
Chemical/Pharm GKB GenePA29631
Clinical trialIDH2
Cancer Resource (Charite)ENSG00000182054
Ontology : AmiGOmagnesium ion binding  isocitrate dehydrogenase (NADP+) activity  isocitrate dehydrogenase (NADP+) activity  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  carbohydrate metabolic process  glyoxylate cycle  tricarboxylic acid cycle  isocitrate metabolic process  2-oxoglutarate metabolic process  small molecule metabolic process  NAD binding  
Ontology : EGO-EBImagnesium ion binding  isocitrate dehydrogenase (NADP+) activity  isocitrate dehydrogenase (NADP+) activity  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  carbohydrate metabolic process  glyoxylate cycle  tricarboxylic acid cycle  isocitrate metabolic process  2-oxoglutarate metabolic process  small molecule metabolic process  NAD binding  
Pathways : KEGGGlutathione metabolismReductive carboxylate cycle (CO2 fixation)Citrate cycle (TCA cycle)
Other databases
Probes
Litterature
PubMed128 Pubmed reference(s) in Entrez
PubGeneIDH2
iHOPIDH2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:23:56 CEST 2013
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