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IDH2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial)

Identity

Other namesD2HGA2
ICD-M
IDH
IDHM
IDP
IDPM
mNADP-IDH
HGNC (Hugo) IDH2
LocusID (NCBI) 3418
Atlas_Id 49969
Location 15q26.1  [Link to chromosome band 15q26]
Location_base_pair Starts at 90627211 and ends at 90643853 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
IDH2 (15q26.1) / IDH2 (15q26.1)IDH2 (15q26.1) / KIF1C (17p13.2)RPS11 (19q13.33) / IDH2 (15q26.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  Classification of myelodysplastic syndromes 2015
Chronic Myelomonocytic Leukemia (CMML)

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Bone: Periosteal chondroma

External links

Nomenclature
HGNC (Hugo)IDH2   5383
Cards
Entrez_Gene (NCBI)IDH2  3418  isocitrate dehydrogenase 2 (NADP+), mitochondrial
AliasesD2HGA2; ICD-M; IDH; IDHM; 
IDP; IDPM; mNADP-IDH
GeneCards (Weizmann)IDH2
Ensembl hg19 (Hinxton)ENSG00000182054 [Gene_View]  chr15:90627211-90643853 [Contig_View]  IDH2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000182054 [Gene_View]  chr15:90627211-90643853 [Contig_View]  IDH2 [Vega]
ICGC DataPortalENSG00000182054
TCGA cBioPortalIDH2
AceView (NCBI)IDH2
Genatlas (Paris)IDH2
WikiGenes3418
SOURCE (Princeton)IDH2
Genomic and cartography
GoldenPath hg19 (UCSC)IDH2  -     chr15:90627211-90643853 -  15q26.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)IDH2  -     15q26.1   [Description]    (hg38-Dec_2013)
EnsemblIDH2 - 15q26.1 [CytoView hg19]  IDH2 - 15q26.1 [CytoView hg38]
Mapping of homologs : NCBIIDH2 [Mapview hg19]  IDH2 [Mapview hg38]
OMIM147650   613657   
Gene and transcription
Genbank (Entrez)AK222916 AK294148 AK299987 AK312627 AK316388
RefSeq transcript (Entrez)NM_001289910 NM_001290114 NM_002168
RefSeq genomic (Entrez)NC_000015 NC_018926 NG_023302 NT_010194 NW_004929399
Consensus coding sequences : CCDS (NCBI)IDH2
Cluster EST : UnigeneHs.596461 [ NCBI ]
CGAP (NCI)Hs.596461
Alternative Splicing GalleryENSG00000182054
Gene ExpressionIDH2 [ NCBI-GEO ]   IDH2 [ EBI - ARRAY_EXPRESS ]   IDH2 [ SEEK ]   IDH2 [ MEM ]
Gene Expression Viewer (FireBrowse)IDH2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3418
GTEX Portal (Tissue expression)IDH2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48735 (Uniprot)
NextProtP48735  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48735
Splice isoforms : SwissVarP48735 (Swissvar)
Catalytic activity : Enzyme1.1.1.42 [ Enzyme-Expasy ]   1.1.1.421.1.1.42 [ IntEnz-EBI ]   1.1.1.42 [ BRENDA ]   1.1.1.42 [ KEGG ]   
PhosPhoSitePlusP48735
Domaine pattern : Prosite (Expaxy)IDH_IMDH (PS00470)   
Domains : Interpro (EBI)IsoCit/isopropylmalate_DH_CS    Isocitrate_DH_NADP    IsoPropMal-DH-like_dom   
Domain families : Pfam (Sanger)Iso_dh (PF00180)   
Domain families : Pfam (NCBI)pfam00180   
DMDM Disease mutations3418
Blocks (Seattle)IDH2
PDB (SRS)4JA8   
PDB (PDBSum)4JA8   
PDB (IMB)4JA8   
PDB (RSDB)4JA8   
Structural Biology KnowledgeBase4JA8   
SCOP (Structural Classification of Proteins)4JA8   
CATH (Classification of proteins structures)4JA8   
SuperfamilyP48735
Human Protein AtlasENSG00000182054
Peptide AtlasP48735
HPRD00973
IPIIPI00011107   IPI01015385   IPI01010649   
Protein Interaction databases
DIP (DOE-UCLA)P48735
IntAct (EBI)P48735
FunCoupENSG00000182054
BioGRIDIDH2
STRING (EMBL)IDH2
ZODIACIDH2
Ontologies - Pathways
QuickGOP48735
Ontology : AmiGOmagnesium ion binding  isocitrate dehydrogenase (NADP+) activity  isocitrate dehydrogenase (NADP+) activity  isocitrate dehydrogenase (NADP+) activity  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  peroxisome  cytosol  carbohydrate metabolic process  glyoxylate cycle  tricarboxylic acid cycle  isocitrate metabolic process  2-oxoglutarate metabolic process  NAD binding  extracellular exosome  
Ontology : EGO-EBImagnesium ion binding  isocitrate dehydrogenase (NADP+) activity  isocitrate dehydrogenase (NADP+) activity  isocitrate dehydrogenase (NADP+) activity  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  peroxisome  cytosol  carbohydrate metabolic process  glyoxylate cycle  tricarboxylic acid cycle  isocitrate metabolic process  2-oxoglutarate metabolic process  NAD binding  extracellular exosome  
Pathways : KEGGCitrate cycle (TCA cycle)    Glutathione metabolism    Peroxisome   
NDEx Network
Atlas of Cancer Signalling NetworkIDH2
Wikipedia pathwaysIDH2
Orthology - Evolution
OrthoDB3418
GeneTree (enSembl)ENSG00000182054
Phylogenetic Trees/Animal Genes : TreeFamIDH2
Homologs : HomoloGeneIDH2
Homology/Alignments : Family Browser (UCSC)IDH2
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerIDH2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IDH2
dbVarIDH2
ClinVarIDH2
1000_GenomesIDH2 
Exome Variant ServerIDH2
ExAC (Exome Aggregation Consortium)IDH2 (select the gene name)
Genetic variants : HAPMAP3418
Genomic Variants (DGV)IDH2 [DGVbeta]
Mutations
ICGC Data PortalIDH2 
TCGA Data PortalIDH2 
Broad Tumor PortalIDH2
OASIS PortalIDH2 [ Somatic mutations - Copy number]
Cancer Gene: CensusIDH2 
Somatic Mutations in Cancer : COSMICIDH2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
LOVD (Leiden Open Variation Database)Vascular Anomaly and Lymphedema Mutation Database
BioMutasearch IDH2
DgiDB (Drug Gene Interaction Database)IDH2
DoCM (Curated mutations)IDH2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IDH2 (select a term)
intoGenIDH2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)15:90627211-90643853  ENSG00000182054
CONAN: Copy Number AnalysisIDH2 
Mutations and Diseases : HGMDIDH2
OMIM147650    613657   
MedgenIDH2
Genetic Testing Registry IDH2
NextProtP48735 [Medical]
TSGene3418
GENETestsIDH2
Huge Navigator IDH2 [HugePedia]
snp3D : Map Gene to Disease3418
BioCentury BCIQIDH2
ClinGenIDH2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3418
Chemical/Pharm GKB GenePA29631
Clinical trialIDH2
Miscellaneous
canSAR (ICR)IDH2 (select the gene name)
Probes
Litterature
PubMed228 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIDH2
EVEXIDH2
GoPubMedIDH2
iHOPIDH2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:04:13 CEST 2016

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