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IFI16 (interferon gamma inducible protein 16)

Identity

Alias_symbol (synonym)IFNGIP1
PYHIN2
Other alias
HGNC (Hugo) IFI16
LocusID (NCBI) 3428
Atlas_Id 43784
Location 1q23.1  [Link to chromosome band 1q23]
Location_base_pair Starts at 159009892 and ends at 159055155 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CEP170 (1q43) / IFI16 (1q23.1)FBXO28 (1q42.11) / IFI16 (1q23.1)HLA-A (6p22.1) / IFI16 (1q23.1)
IFI16 (1q23.1) / ENO1 (1p36.23)MTR (1q43) / IFI16 (1q23.1)cytochrome_b () / IFI16 (1q23.1)
CEP170 1q43 / IFI16 1q23.1MTR 1q43 / IFI16 1q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)IFI16   5395
Cards
Entrez_Gene (NCBI)IFI16  3428  interferon gamma inducible protein 16
AliasesIFNGIP1; PYHIN2
GeneCards (Weizmann)IFI16
Ensembl hg19 (Hinxton)ENSG00000163565 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163565 [Gene_View]  chr1:159009892-159055155 [Contig_View]  IFI16 [Vega]
ICGC DataPortalENSG00000163565
TCGA cBioPortalIFI16
AceView (NCBI)IFI16
Genatlas (Paris)IFI16
WikiGenes3428
SOURCE (Princeton)IFI16
Genetics Home Reference (NIH)IFI16
Genomic and cartography
GoldenPath hg38 (UCSC)IFI16  -     chr1:159009892-159055155 +  1q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IFI16  -     1q23.1   [Description]    (hg19-Feb_2009)
EnsemblIFI16 - 1q23.1 [CytoView hg19]  IFI16 - 1q23.1 [CytoView hg38]
Mapping of homologs : NCBIIFI16 [Mapview hg19]  IFI16 [Mapview hg38]
OMIM147586   
Gene and transcription
Genbank (Entrez)AB208989 AF086545 AF208043 AK094968 AK296228
RefSeq transcript (Entrez)NM_001206567 NM_005531
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IFI16
Cluster EST : UnigeneHs.380250 [ NCBI ]
CGAP (NCI)Hs.380250
Alternative Splicing GalleryENSG00000163565
Gene ExpressionIFI16 [ NCBI-GEO ]   IFI16 [ EBI - ARRAY_EXPRESS ]   IFI16 [ SEEK ]   IFI16 [ MEM ]
Gene Expression Viewer (FireBrowse)IFI16 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3428
GTEX Portal (Tissue expression)IFI16
Human Protein AtlasENSG00000163565-IFI16 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16666   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16666  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16666
Splice isoforms : SwissVarQ16666
PhosPhoSitePlusQ16666
Domaine pattern : Prosite (Expaxy)DAPIN (PS50824)    HIN_200 (PS50834)   
Domains : Interpro (EBI)DAPIN    HIN200/IF120x   
Domain families : Pfam (Sanger)HIN (PF02760)    PYRIN (PF02758)   
Domain families : Pfam (NCBI)pfam02760    pfam02758   
Domain families : Smart (EMBL)PYRIN (SM01289)  
Conserved Domain (NCBI)IFI16
DMDM Disease mutations3428
Blocks (Seattle)IFI16
PDB (SRS)2OQ0    3B6Y    3RLN    3RLO    3RNU    4QGU   
PDB (PDBSum)2OQ0    3B6Y    3RLN    3RLO    3RNU    4QGU   
PDB (IMB)2OQ0    3B6Y    3RLN    3RLO    3RNU    4QGU   
PDB (RSDB)2OQ0    3B6Y    3RLN    3RLO    3RNU    4QGU   
Structural Biology KnowledgeBase2OQ0    3B6Y    3RLN    3RLO    3RNU    4QGU   
SCOP (Structural Classification of Proteins)2OQ0    3B6Y    3RLN    3RLO    3RNU    4QGU   
CATH (Classification of proteins structures)2OQ0    3B6Y    3RLN    3RLO    3RNU    4QGU   
SuperfamilyQ16666
Human Protein Atlas [tissue]ENSG00000163565-IFI16 [tissue]
Peptide AtlasQ16666
HPRD00969
IPIIPI00003443   IPI00217475   IPI00384836   IPI00909417   IPI00217474   IPI00642094   IPI00940508   
Protein Interaction databases
DIP (DOE-UCLA)Q16666
IntAct (EBI)Q16666
FunCoupENSG00000163565
BioGRIDIFI16
STRING (EMBL)IFI16
ZODIACIFI16
Ontologies - Pathways
QuickGOQ16666
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  negative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  core promoter binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  positive regulation of cytokine production  activation of innate immune response  double-stranded DNA binding  RNA binding  protein binding  nucleus  nucleoplasm  nucleolus  cytosol  cytosol  transcription, DNA-templated  autophagy  inflammatory response  transcription factor binding  cell proliferation  regulation of autophagy  membrane  nuclear speck  hemopoiesis  myeloid cell differentiation  monocyte differentiation  positive regulation of type I interferon production  positive regulation of interleukin-1 beta production  regulation of gene expression, epigenetic  cellular response to glucose starvation  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  negative regulation of DNA binding  negative regulation of viral genome replication  innate immune response  negative regulation of innate immune response  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  defense response to virus  cellular response to ionizing radiation  intrinsic apoptotic signaling pathway by p53 class mediator  activation of cysteine-type endopeptidase activity  negative regulation of cysteine-type endopeptidase activity  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  negative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  core promoter binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  positive regulation of cytokine production  activation of innate immune response  double-stranded DNA binding  RNA binding  protein binding  nucleus  nucleoplasm  nucleolus  cytosol  cytosol  transcription, DNA-templated  autophagy  inflammatory response  transcription factor binding  cell proliferation  regulation of autophagy  membrane  nuclear speck  hemopoiesis  myeloid cell differentiation  monocyte differentiation  positive regulation of type I interferon production  positive regulation of interleukin-1 beta production  regulation of gene expression, epigenetic  cellular response to glucose starvation  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  negative regulation of DNA binding  negative regulation of viral genome replication  innate immune response  negative regulation of innate immune response  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  defense response to virus  cellular response to ionizing radiation  intrinsic apoptotic signaling pathway by p53 class mediator  activation of cysteine-type endopeptidase activity  negative regulation of cysteine-type endopeptidase activity  
NDEx NetworkIFI16
Atlas of Cancer Signalling NetworkIFI16
Wikipedia pathwaysIFI16
Orthology - Evolution
OrthoDB3428
GeneTree (enSembl)ENSG00000163565
Phylogenetic Trees/Animal Genes : TreeFamIFI16
HOVERGENQ16666
HOGENOMQ16666
Homologs : HomoloGeneIFI16
Homology/Alignments : Family Browser (UCSC)IFI16
Gene fusions - Rearrangements
Fusion : MitelmanCEP170/IFI16 [1q43/1q23.1]  [t(1;1)(q23;q43)]  
Fusion : MitelmanMTR/IFI16 [1q43/1q23.1]  [t(1;1)(q23;q43)]  
Fusion: TCGA_MDACCCEP170 1q43 IFI16 1q23.1 PRAD
Fusion: TCGA_MDACCMTR 1q43 IFI16 1q23.1 BRCA
Tumor Fusion PortalIFI16
Fusion Cancer (Beijing)HLA-A [6p22.1]  -  IFI16 [1q23.1]  [FUSC000440]
Fusion Cancer (Beijing)cytochrome_b [IFI16]  -  1q23.1 [FUSC002835]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIFI16 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IFI16
dbVarIFI16
ClinVarIFI16
1000_GenomesIFI16 
Exome Variant ServerIFI16
ExAC (Exome Aggregation Consortium)ENSG00000163565
GNOMAD BrowserENSG00000163565
Genetic variants : HAPMAP3428
Genomic Variants (DGV)IFI16 [DGVbeta]
DECIPHERIFI16 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIFI16 
Mutations
ICGC Data PortalIFI16 
TCGA Data PortalIFI16 
Broad Tumor PortalIFI16
OASIS PortalIFI16 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIFI16  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIFI16
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IFI16
DgiDB (Drug Gene Interaction Database)IFI16
DoCM (Curated mutations)IFI16 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IFI16 (select a term)
intoGenIFI16
Cancer3DIFI16(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147586   
Orphanet
DisGeNETIFI16
MedgenIFI16
Genetic Testing Registry IFI16
NextProtQ16666 [Medical]
TSGene3428
GENETestsIFI16
Target ValidationIFI16
Huge Navigator IFI16 [HugePedia]
snp3D : Map Gene to Disease3428
BioCentury BCIQIFI16
ClinGenIFI16
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3428
Chemical/Pharm GKB GenePA29642
Clinical trialIFI16
Miscellaneous
canSAR (ICR)IFI16 (select the gene name)
Probes
Litterature
PubMed128 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIFI16
EVEXIFI16
GoPubMedIFI16
iHOPIFI16
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:17:13 CET 2017

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