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IFIH1 (interferon induced with helicase C domain 1)

Identity

Alias (NCBI)AGS7
Hlcd
IDDM19
MDA-5
MDA5
RLR-2
SGMRT1
HGNC (Hugo) IFIH1
HGNC Alias symbMDA-5
Hlcd
MDA5
IDDM19
HGNC Alias namehelicard
 melanoma differentiation-associated gene 5
LocusID (NCBI) 64135
Atlas_Id 41325
Location 2q24.2  [Link to chromosome band 2q24]
Location_base_pair Starts at 162267074 and ends at 162318684 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAP (2q24.2) / IFIH1 (2q24.2)GRB14 (2q24.3) / IFIH1 (2q24.2)IFIH1 (2q24.2) / IFIH1 (2q24.2)
PDLIM5 (4q22.3) / IFIH1 (2q24.2)SI (3q26.1) / IFIH1 (2q24.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)IFIH1   18873
Cards
Entrez_Gene (NCBI)IFIH1    interferon induced with helicase C domain 1
AliasesAGS7; Hlcd; IDDM19; MDA-5; 
MDA5; RLR-2; SGMRT1
GeneCards (Weizmann)IFIH1
Ensembl hg19 (Hinxton)ENSG00000115267 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115267 [Gene_View]  ENSG00000115267 [Sequence]  chr2:162267074-162318684 [Contig_View]  IFIH1 [Vega]
ICGC DataPortalENSG00000115267
TCGA cBioPortalIFIH1
AceView (NCBI)IFIH1
Genatlas (Paris)IFIH1
SOURCE (Princeton)IFIH1
Genetics Home Reference (NIH)IFIH1
Genomic and cartography
GoldenPath hg38 (UCSC)IFIH1  -     chr2:162267074-162318684 -  2q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IFIH1  -     2q24.2   [Description]    (hg19-Feb_2009)
GoldenPathIFIH1 - 2q24.2 [CytoView hg19]  IFIH1 - 2q24.2 [CytoView hg38]
ImmunoBaseENSG00000115267
Genome Data Viewer NCBIIFIH1 [Mapview hg19]  
OMIM182250   606951   615846   
Gene and transcription
Genbank (Entrez)AF095844 AK056293 AK292941 AK314611 AY017378
RefSeq transcript (Entrez)NM_022168
Consensus coding sequences : CCDS (NCBI)IFIH1
Gene ExpressionIFIH1 [ NCBI-GEO ]   IFIH1 [ EBI - ARRAY_EXPRESS ]   IFIH1 [ SEEK ]   IFIH1 [ MEM ]
Gene Expression Viewer (FireBrowse)IFIH1 [ Firebrowse - Broad ]
GenevisibleExpression of IFIH1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64135
GTEX Portal (Tissue expression)IFIH1
Human Protein AtlasENSG00000115267-IFIH1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BYX4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BYX4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BYX4
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9BYX4
Domaine pattern : Prosite (Expaxy)HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)    RLR_CTR (PS51789)   
Domains : Interpro (EBI)CARD_dom    Helicase/UvrB_N    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    RIG-I_C    RLR_C_sf    RLR_CTR   
Domain families : Pfam (Sanger)CARD_2 (PF16739)    Helicase_C (PF00271)    ResIII (PF04851)    RIG-I_C (PF18119)    RIG-I_C-RD (PF11648)   
Domain families : Pfam (NCBI)pfam16739    pfam00271    pfam04851    pfam18119    pfam11648   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  
Conserved Domain (NCBI)IFIH1
PDB (RSDB)2RQB    3B6E    3GA3    4GL2   
PDB Europe2RQB    3B6E    3GA3    4GL2   
PDB (PDBSum)2RQB    3B6E    3GA3    4GL2   
PDB (IMB)2RQB    3B6E    3GA3    4GL2   
Structural Biology KnowledgeBase2RQB    3B6E    3GA3    4GL2   
SCOP (Structural Classification of Proteins)2RQB    3B6E    3GA3    4GL2   
CATH (Classification of proteins structures)2RQB    3B6E    3GA3    4GL2   
SuperfamilyQ9BYX4
AlphaFold pdb e-kbQ9BYX4   
Human Protein Atlas [tissue]ENSG00000115267-IFIH1 [tissue]
HPRD09507
Protein Interaction databases
DIP (DOE-UCLA)Q9BYX4
IntAct (EBI)Q9BYX4
BioGRIDIFIH1
STRING (EMBL)IFIH1
ZODIACIFIH1
Ontologies - Pathways
QuickGOQ9BYX4
Ontology : AmiGODNA binding  RNA binding  RNA helicase activity  double-stranded RNA binding  double-stranded RNA binding  double-stranded RNA binding  single-stranded RNA binding  single-stranded RNA binding  protein binding  ATP binding  nucleus  cytoplasm  cytoplasm  mitochondrion  cytosol  zinc ion binding  zinc ion binding  detection of virus  response to virus  response to virus  response to virus  protein deubiquitination  hydrolase activity  protein sumoylation  negative regulation of type I interferon production  positive regulation of interferon-alpha production  positive regulation of interferon-alpha production  positive regulation of interferon-beta production  positive regulation of interferon-beta production  positive regulation of interferon-beta production  positive regulation of interferon-beta production  positive regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  regulation of type III interferon production  cytoplasmic pattern recognition receptor signaling pathway in response to virus  MDA-5 signaling pathway  identical protein binding  identical protein binding  ribonucleoprotein complex binding  negative regulation of viral genome replication  innate immune response  innate immune response  defense response to virus  positive regulation of response to cytokine stimulus  cellular response to exogenous dsRNA  cellular response to virus  
Ontology : EGO-EBIDNA binding  RNA binding  RNA helicase activity  double-stranded RNA binding  double-stranded RNA binding  double-stranded RNA binding  single-stranded RNA binding  single-stranded RNA binding  protein binding  ATP binding  nucleus  cytoplasm  cytoplasm  mitochondrion  cytosol  zinc ion binding  zinc ion binding  detection of virus  response to virus  response to virus  response to virus  protein deubiquitination  hydrolase activity  protein sumoylation  negative regulation of type I interferon production  positive regulation of interferon-alpha production  positive regulation of interferon-alpha production  positive regulation of interferon-beta production  positive regulation of interferon-beta production  positive regulation of interferon-beta production  positive regulation of interferon-beta production  positive regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  regulation of type III interferon production  cytoplasmic pattern recognition receptor signaling pathway in response to virus  MDA-5 signaling pathway  identical protein binding  identical protein binding  ribonucleoprotein complex binding  negative regulation of viral genome replication  innate immune response  innate immune response  defense response to virus  positive regulation of response to cytokine stimulus  cellular response to exogenous dsRNA  cellular response to virus  
Pathways : KEGGRIG-I-like receptor signaling pathway    Hepatitis B    Measles    Influenza A    Herpes simplex infection   
NDEx NetworkIFIH1
Atlas of Cancer Signalling NetworkIFIH1
Wikipedia pathwaysIFIH1
Orthology - Evolution
OrthoDB64135
GeneTree (enSembl)ENSG00000115267
Phylogenetic Trees/Animal Genes : TreeFamIFIH1
Homologs : HomoloGeneIFIH1
Homology/Alignments : Family Browser (UCSC)IFIH1
Gene fusions - Rearrangements
Fusion : QuiverIFIH1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIFIH1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IFIH1
dbVarIFIH1
ClinVarIFIH1
MonarchIFIH1
1000_GenomesIFIH1 
Exome Variant ServerIFIH1
GNOMAD BrowserENSG00000115267
Varsome BrowserIFIH1
ACMGIFIH1 variants
VarityQ9BYX4
Genomic Variants (DGV)IFIH1 [DGVbeta]
DECIPHERIFIH1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIFIH1 
Mutations
ICGC Data PortalIFIH1 
TCGA Data PortalIFIH1 
Broad Tumor PortalIFIH1
OASIS PortalIFIH1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIFIH1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIFIH1
Mutations and Diseases : HGMDIFIH1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIFIH1
DgiDB (Drug Gene Interaction Database)IFIH1
DoCM (Curated mutations)IFIH1
CIViC (Clinical Interpretations of Variants in Cancer)IFIH1
Cancer3DIFIH1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182250    606951    615846   
Orphanet1309    11649   
DisGeNETIFIH1
MedgenIFIH1
Genetic Testing Registry IFIH1
NextProtQ9BYX4 [Medical]
GENETestsIFIH1
Target ValidationIFIH1
Huge Navigator IFIH1 [HugePedia]
ClinGenIFIH1
Clinical trials, drugs, therapy
MyCancerGenomeIFIH1
Protein Interactions : CTDIFIH1
Pharm GKB GenePA134889215
PharosQ9BYX4
Clinical trialIFIH1
Miscellaneous
canSAR (ICR)IFIH1
HarmonizomeIFIH1
DataMed IndexIFIH1
Probes
Litterature
PubMed271 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIFIH1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:13:21 CEST 2021

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