IFIH1 (interferon induced with helicase C domain 1)

2003-02-01  

Identity

HGNC
LOCATION
2q24.2
LOCUSID
ALIAS
AGS7,Hlcd,IDDM19,MDA-5,MDA5,RLR-2,SGMRT1
FUSION GENES

Other Information

Locus ID:

NCBI: 64135
MIM: 606951
HGNC: 18873
Ensembl: ENSG00000115267

Variants:

dbSNP: 64135
ClinVar: 64135
TCGA: ENSG00000115267
COSMIC: IFIH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115267ENST00000421365Q9BYX4
ENSG00000115267ENST00000648433A0A3B3IRK8
ENSG00000115267ENST00000649979Q9BYX4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Hepatitis BKEGGhsa05161
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
TRAF3-dependent IRF activation pathwayREACTOMER-HSA-918233
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10REACTOMER-HSA-933543
TRAF6 mediated IRF7 activationREACTOMER-HSA-933541
TRAF6 mediated NF-kB activationREACTOMER-HSA-933542
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880
Ovarian tumor domain proteasesREACTOMER-HSA-5689896

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
161161712005Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity.546
155635932004The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter.408
192649852009Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes.405
192649852009Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes.405
198381952009A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.316
209531902010A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.309
190739672008Shared and distinct genetic variants in type 1 diabetes and celiac disease.249
166995172006A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.220
166995172006A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.220
118053212002mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties.205

Citation

Dessen P

IFIH1 (interferon induced with helicase C domain 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41325/ifih1