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IFIT2 (interferon induced protein with tetratricopeptide repeats 2)

Identity

Alias (NCBI)G10P2
GARG-39
IFI-54
IFI-54K
IFI54
IFIT-2
ISG-54
ISG-54 K
ISG-54K
ISG54
P54
cig42
HGNC (Hugo) IFIT2
HGNC Alias symbIFI-54
ISG-54K
ISG-54
cig42
GARG-39
HGNC Previous nameIFI54
 G10P2
HGNC Previous nameinterferon-induced protein with tetratricopeptide repeats 2
LocusID (NCBI) 3433
Atlas_Id 47644
Location 10q23.31  [Link to chromosome band 10q23]
Location_base_pair Starts at 89302046 and ends at 89309271 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)IFIT2   5409
Cards
Entrez_Gene (NCBI)IFIT2    interferon induced protein with tetratricopeptide repeats 2
AliasesG10P2; GARG-39; IFI-54; IFI-54K; 
IFI54; IFIT-2; ISG-54; ISG-54; ISG-54K; ISG54; P54; cig42
GeneCards (Weizmann)IFIT2
Ensembl hg19 (Hinxton)ENSG00000119922 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119922 [Gene_View]  ENSG00000119922 [Sequence]  chr10:89302046-89309271 [Contig_View]  IFIT2 [Vega]
ICGC DataPortalENSG00000119922
TCGA cBioPortalIFIT2
AceView (NCBI)IFIT2
Genatlas (Paris)IFIT2
SOURCE (Princeton)IFIT2
Genetics Home Reference (NIH)IFIT2
Genomic and cartography
GoldenPath hg38 (UCSC)IFIT2  -     chr10:89302046-89309271 +  10q23.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IFIT2  -     10q23.31   [Description]    (hg19-Feb_2009)
GoldenPathIFIT2 - 10q23.31 [CytoView hg19]  IFIT2 - 10q23.31 [CytoView hg38]
ImmunoBaseENSG00000119922
Genome Data Viewer NCBIIFIT2 [Mapview hg19]  
OMIM147040   
Gene and transcription
Genbank (Entrez)AA143609 AA765174 AF026944 AK300431 AK312831
RefSeq transcript (Entrez)NM_001547
Consensus coding sequences : CCDS (NCBI)IFIT2
Gene ExpressionIFIT2 [ NCBI-GEO ]   IFIT2 [ EBI - ARRAY_EXPRESS ]   IFIT2 [ SEEK ]   IFIT2 [ MEM ]
Gene Expression Viewer (FireBrowse)IFIT2 [ Firebrowse - Broad ]
GenevisibleExpression of IFIT2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3433
GTEX Portal (Tissue expression)IFIT2
Human Protein AtlasENSG00000119922-IFIT2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09913   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09913  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09913
PhosPhoSitePlusP09913
Domaine pattern : Prosite (Expaxy)TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)Interferon-induced_IFIT2    TPR-contain_dom    TPR-like_helical_dom_sf    TPR_repeat   
Domain families : Pfam (Sanger)TPR_8 (PF13181)   
Domain families : Pfam (NCBI)pfam13181   
Domain families : Smart (EMBL)TPR (SM00028)  
Conserved Domain (NCBI)IFIT2
PDB (RSDB)4G1T   
PDB Europe4G1T   
PDB (PDBSum)4G1T   
PDB (IMB)4G1T   
Structural Biology KnowledgeBase4G1T   
SCOP (Structural Classification of Proteins)4G1T   
CATH (Classification of proteins structures)4G1T   
SuperfamilyP09913
AlphaFold pdb e-kbP09913   
Human Protein Atlas [tissue]ENSG00000119922-IFIT2 [tissue]
HPRD00913
Protein Interaction databases
DIP (DOE-UCLA)P09913
IntAct (EBI)P09913
BioGRIDIFIT2
STRING (EMBL)IFIT2
ZODIACIFIT2
Ontologies - Pathways
QuickGOP09913
Ontology : AmiGORNA binding  RNA binding  protein binding  cytoplasm  endoplasmic reticulum  cytosol  cytosol  apoptotic mitochondrial changes  response to virus  response to virus  negative regulation of protein binding  cellular response to interferon-alpha  positive regulation of apoptotic process  defense response to virus  type I interferon signaling pathway  
Ontology : EGO-EBIRNA binding  RNA binding  protein binding  cytoplasm  endoplasmic reticulum  cytosol  cytosol  apoptotic mitochondrial changes  response to virus  response to virus  negative regulation of protein binding  cellular response to interferon-alpha  positive regulation of apoptotic process  defense response to virus  type I interferon signaling pathway  
NDEx NetworkIFIT2
Atlas of Cancer Signalling NetworkIFIT2
Wikipedia pathwaysIFIT2
Orthology - Evolution
OrthoDB3433
GeneTree (enSembl)ENSG00000119922
Phylogenetic Trees/Animal Genes : TreeFamIFIT2
Homologs : HomoloGeneIFIT2
Homology/Alignments : Family Browser (UCSC)IFIT2
Gene fusions - Rearrangements
Fusion : QuiverIFIT2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIFIT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IFIT2
dbVarIFIT2
ClinVarIFIT2
MonarchIFIT2
1000_GenomesIFIT2 
Exome Variant ServerIFIT2
GNOMAD BrowserENSG00000119922
Varsome BrowserIFIT2
ACMGIFIT2 variants
VarityP09913
Genomic Variants (DGV)IFIT2 [DGVbeta]
DECIPHERIFIT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIFIT2 
Mutations
ICGC Data PortalIFIT2 
TCGA Data PortalIFIT2 
Broad Tumor PortalIFIT2
OASIS PortalIFIT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIFIT2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIFIT2
Mutations and Diseases : HGMDIFIT2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIFIT2
DgiDB (Drug Gene Interaction Database)IFIT2
DoCM (Curated mutations)IFIT2
CIViC (Clinical Interpretations of Variants in Cancer)IFIT2
Cancer3DIFIT2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147040   
Orphanet
DisGeNETIFIT2
MedgenIFIT2
Genetic Testing Registry IFIT2
NextProtP09913 [Medical]
GENETestsIFIT2
Target ValidationIFIT2
Huge Navigator IFIT2 [HugePedia]
ClinGenIFIT2
Clinical trials, drugs, therapy
MyCancerGenomeIFIT2
Protein Interactions : CTDIFIT2
Pharm GKB GenePA29650
PharosP09913
Clinical trialIFIT2
Miscellaneous
canSAR (ICR)IFIT2
HarmonizomeIFIT2
DataMed IndexIFIT2
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIFIT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:13:22 CEST 2021

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