IFIT5 (interferon induced protein with tetratricopeptide repeats 5)

2014-11-01  

Identity

HGNC
LOCATION
10q23.31
LOCUSID
ALIAS
ISG58,P58,RI58
FUSION GENES

Other Information

Locus ID:

NCBI: 24138
MIM: 616135
HGNC: 13328
Ensembl: ENSG00000152778

Variants:

dbSNP: 24138
ClinVar: 24138
TCGA: ENSG00000152778
COSMIC: IFIT5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152778ENST00000371795Q13325

Expression (GTEx)

0
5
10
15
20
25

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
233344202013Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins.95
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
250923122014Broad and adaptable RNA structure recognition by the human interferon-induced tetratricopeptide repeat protein IFIT5.35
233175052013tRNA binding, structure, and localization of the human interferon-induced protein IFIT5.33
237742682013Crystal structure and nucleotide selectivity of human IFIT5/ISG58.15
263343752015IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1).12
243115832013The TLR signalling adaptor TRIF/TICAM-1 has an N-terminal helical domain with structural similarity to IFIT proteins.2

Citation

Dessen P

IFIT5 (interferon induced protein with tetratricopeptide repeats 5)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64510/ifit5