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IFIT5 (interferon induced protein with tetratricopeptide repeats 5)

Identity

Alias (NCBI)ISG58
P58
RI58
HGNC (Hugo) IFIT5
HGNC Alias symbRI58
HGNC Alias nameretinoic acid- and interferon-inducible protein (58kD)
HGNC Previous nameinterferon-induced protein with tetratricopeptide repeats 5
LocusID (NCBI) 24138
Atlas_Id 64510
Location 10q23.31  [Link to chromosome band 10q23]
Location_base_pair Starts at 89414568 and ends at 89420997 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANK3 (10q21.2) / IFIT5 (10q23.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)IFIT5   13328
Cards
Entrez_Gene (NCBI)IFIT5    interferon induced protein with tetratricopeptide repeats 5
AliasesISG58; P58; RI58
GeneCards (Weizmann)IFIT5
Ensembl hg19 (Hinxton)ENSG00000152778 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152778 [Gene_View]  ENSG00000152778 [Sequence]  chr10:89414568-89420997 [Contig_View]  IFIT5 [Vega]
ICGC DataPortalENSG00000152778
TCGA cBioPortalIFIT5
AceView (NCBI)IFIT5
Genatlas (Paris)IFIT5
SOURCE (Princeton)IFIT5
Genetics Home Reference (NIH)IFIT5
Genomic and cartography
GoldenPath hg38 (UCSC)IFIT5  -     chr10:89414568-89420997 +  10q23.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IFIT5  -     10q23.31   [Description]    (hg19-Feb_2009)
GoldenPathIFIT5 - 10q23.31 [CytoView hg19]  IFIT5 - 10q23.31 [CytoView hg38]
ImmunoBaseENSG00000152778
Genome Data Viewer NCBIIFIT5 [Mapview hg19]  
OMIM616135   
Gene and transcription
Genbank (Entrez)AK293346 AK312358 BC025786 CR457031 DC392439
RefSeq transcript (Entrez)NM_012420
Consensus coding sequences : CCDS (NCBI)IFIT5
Gene ExpressionIFIT5 [ NCBI-GEO ]   IFIT5 [ EBI - ARRAY_EXPRESS ]   IFIT5 [ SEEK ]   IFIT5 [ MEM ]
Gene Expression Viewer (FireBrowse)IFIT5 [ Firebrowse - Broad ]
GenevisibleExpression of IFIT5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)24138
GTEX Portal (Tissue expression)IFIT5
Human Protein AtlasENSG00000152778-IFIT5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13325   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13325  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13325
PhosPhoSitePlusQ13325
Domaine pattern : Prosite (Expaxy)TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)Interferon_induced_IFIT5    TPR-contain_dom    TPR-like_helical_dom_sf    TPR_2    TPR_repeat   
Domain families : Pfam (Sanger)TPR_2 (PF07719)    TPR_8 (PF13181)   
Domain families : Pfam (NCBI)pfam07719    pfam13181   
Domain families : Smart (EMBL)TPR (SM00028)  
Conserved Domain (NCBI)IFIT5
PDB (RSDB)3ZGQ    4HOQ    4HOR    4HOS    4HOT    4J0U   
PDB Europe3ZGQ    4HOQ    4HOR    4HOS    4HOT    4J0U   
PDB (PDBSum)3ZGQ    4HOQ    4HOR    4HOS    4HOT    4J0U   
PDB (IMB)3ZGQ    4HOQ    4HOR    4HOS    4HOT    4J0U   
Structural Biology KnowledgeBase3ZGQ    4HOQ    4HOR    4HOS    4HOT    4J0U   
SCOP (Structural Classification of Proteins)3ZGQ    4HOQ    4HOR    4HOS    4HOT    4J0U   
CATH (Classification of proteins structures)3ZGQ    4HOQ    4HOR    4HOS    4HOT    4J0U   
SuperfamilyQ13325
AlphaFold pdb e-kbQ13325   
Human Protein Atlas [tissue]ENSG00000152778-IFIT5 [tissue]
HPRD17130
Protein Interaction databases
DIP (DOE-UCLA)Q13325
IntAct (EBI)Q13325
BioGRIDIFIT5
STRING (EMBL)IFIT5
ZODIACIFIT5
Ontologies - Pathways
QuickGOQ13325
Ontology : AmiGOtRNA binding  RNA cap binding  double-stranded DNA binding  RNA binding  RNA binding  RNA binding  single-stranded RNA binding  protein binding  cytosol  cytosol  plasma membrane  poly(U) RNA binding  actin cytoskeleton  ruffle membrane  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of viral genome replication  apical part of cell  defense response to virus  defense response to virus  type I interferon signaling pathway  
Ontology : EGO-EBItRNA binding  RNA cap binding  double-stranded DNA binding  RNA binding  RNA binding  RNA binding  single-stranded RNA binding  protein binding  cytosol  cytosol  plasma membrane  poly(U) RNA binding  actin cytoskeleton  ruffle membrane  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of viral genome replication  apical part of cell  defense response to virus  defense response to virus  type I interferon signaling pathway  
NDEx NetworkIFIT5
Atlas of Cancer Signalling NetworkIFIT5
Wikipedia pathwaysIFIT5
Orthology - Evolution
OrthoDB24138
GeneTree (enSembl)ENSG00000152778
Phylogenetic Trees/Animal Genes : TreeFamIFIT5
Homologs : HomoloGeneIFIT5
Homology/Alignments : Family Browser (UCSC)IFIT5
Gene fusions - Rearrangements
Fusion : QuiverIFIT5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIFIT5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IFIT5
dbVarIFIT5
ClinVarIFIT5
MonarchIFIT5
1000_GenomesIFIT5 
Exome Variant ServerIFIT5
GNOMAD BrowserENSG00000152778
Varsome BrowserIFIT5
ACMGIFIT5 variants
VarityQ13325
Genomic Variants (DGV)IFIT5 [DGVbeta]
DECIPHERIFIT5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIFIT5 
Mutations
ICGC Data PortalIFIT5 
TCGA Data PortalIFIT5 
Broad Tumor PortalIFIT5
OASIS PortalIFIT5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIFIT5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DIFIT5
Mutations and Diseases : HGMDIFIT5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaIFIT5
DgiDB (Drug Gene Interaction Database)IFIT5
DoCM (Curated mutations)IFIT5
CIViC (Clinical Interpretations of Variants in Cancer)IFIT5
Cancer3DIFIT5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616135   
Orphanet
DisGeNETIFIT5
MedgenIFIT5
Genetic Testing Registry IFIT5
NextProtQ13325 [Medical]
GENETestsIFIT5
Target ValidationIFIT5
Huge Navigator IFIT5 [HugePedia]
ClinGenIFIT5
Clinical trials, drugs, therapy
MyCancerGenomeIFIT5
Protein Interactions : CTDIFIT5
Pharm GKB GenePA134988392
PharosQ13325
Clinical trialIFIT5
Miscellaneous
canSAR (ICR)IFIT5
HarmonizomeIFIT5
DataMed IndexIFIT5
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXIFIT5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:53:28 CEST 2021

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