IFITM2 (interferon induced transmembrane protein 2)

2010-01-01  

Identity

HGNC
IFITM2
LOCATION
11p15.5
LOCUSID
10581
ALIAS
1-8D,DSPA2c
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10581
MIM: 605578
HGNC: 5413
Ensembl: ENSG00000185201

Variants:

dbSNP: 10581
ClinVar: 10581
TCGA: ENSG00000185201
COSMIC: IFITM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185201ENST00000399815H7BYV1
ENSG00000185201ENST00000399817Q01629
ENSG00000185201ENST00000527146H0YCL2
ENSG00000185201ENST00000533141E9PQN9
ENSG00000185201ENST00000602569E9PQN9
ENSG00000185201ENST00000616316Q01629

Expression (GTEx)

0
1000
2000
3000
4000
5000
6000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
211778062011The IFITM proteins inhibit HIV-1 infection.187
205348632010Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections.175
249920362014G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA.96
237207212013IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus.68
254648292014IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread.65
263879452015IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein.64
254220702014IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity.49
263544362015The Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3 Inhibit Hepatitis C Virus Entry.46
233761652013Characteristics of IFITM, the newly identified IFN-inducible anti-HIV-1 family proteins.36
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29

Citation

Dessen P

IFITM2 (interferon induced transmembrane protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51270/ifitm2